46 completed, 14 unknown, 7 recruiting, 3 active not recruiting. 78 Phase 3, 14 Phase 2.
Follow Puerperal Disorders: new trials by email Literature Review of Puerperal Disorders trials Research Report on Puerperal Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Brexanolone Lifting Outcomes Of Moms LPCN 1154A, Placebo - Depression, Postpartum, Postpartum Depression (PPD) | Phase 3 | Recruiting | Lipocine Inc. | 120 | 2026-09-01 | 2026-09-16 |
| A Study of MI078 for Postpartum Depression MI078 capsule, Placebo of MI078 capsules - Postpartum Depression (PPD) | Phase 3 | Recruiting | Nanjing Minova Pharmaceutical Co., Ltd. | 200 | 2026-07-10 | 2026-07-23 |
| The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity Aspirin, Low-molecular-weight heparin - Venous Thromboembolism, Postpartum Period | Phase 3 | Recruiting | University of Calgary | 8805 | 2026-06-04 | 2026-07-27 |
| Investigating the Efficacy of Tranexamic Acid as a Prophylactic Agent in Reducing Postpartum Hemorrhage Among Patients Undergoing Cesarean Section in SQUH tranexamic acid (1 g diluted in 100 mL of 0.9% saline, Normal (0.9%) saline - Post Partum Haemorrhage | Phase 3 | Not yet recruiting | Sultan Qaboos University | 88 | 2026-05-01 | 2026-04-01 |
| EVE TRIAL , ALMA SYSTAM Alma System - Postpartum Haemorrhage (PPH), PPH | Phase 3 | Recruiting | ResQ Medical Ltd | 50 | 2026-01-11 | 2026-03-30 |
| The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series interpersonal psychotherapy (IPT), Ketamine - Postpartum Depression | Phase 2 / Phase 3 | Withdrawn | Washington University School of Medicine | 2025-10-15 | 2025-10-29 | |
| A Study to Assess the Safety and Efficacy of Oral LPCN 1154A in Women With Severe PPD LPCN 1154A, Placebo - Depression, Postpartum, Depression, Post-Partum | Phase 3 | Completed | Lipocine Inc. | 90 | 2025-06-16 | 2026-02-24 |
| Double Simultaneous Uterotonic Agents Versus Single Agent Regimen to Prevent Early Postpartum Hemorrhage Sublingual Misoprostol, IV Oxytocin - Postpartum Hemorrhage | Phase 3 | Recruiting | Stony Brook University | 1358 | 2025-01-27 | 2025-05-04 |
| Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section Misoprostol - Postpartum Hemorrhage | Phase 3 | Not yet recruiting | Assiut University | 400 | 2025-01-01 | 2025-01-09 |
| Prophylactic Amnioinfusion for Prevention of Postpartum Hemorrhage Saline delivered using an intrauterine pressure catheter (IUPC) - Postpartum Hemorrhage | Phase 3 | Not yet recruiting | The University of Texas Health Science Center, Houston | 700 | 2024-11-11 | 2024-11-18 |
| Comparing Intramyometrial Tranexamic Acid and Oxytocin for Blood Loss in Cesarean Section Tranexamic acid injection, Oxytocin - Cesarean Section Complications, Tranexamic Acid | Phase 3 | Unknown | Cairo University | 150 | 2024-10-01 | 2024-09-05 |
| Tranexamic Acid to Prevent Heavy Bleeding After Childbirth in Women At Higher Risk Tranexamic acid, Placebo - Postpartum Hemorrhage | Phase 3 | Recruiting | London School of Hygiene and Tropical Medicine | 30000 | 2024-04-22 | 2025-03-11 |
| Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa Tranexamic acid, 0.9% sodium chloride - Hemorrhage, Postpartum, Placenta Previa | Phase 3 | Completed | Guangzhou Medical University | 1732 | 2023-07-12 | 2025-03-27 |
| Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women MWSH plus Candlelit Care, MWSH - Pregnancy Related, Pregnancy Complications | Phase 2 / Phase 3 | Active not recruiting | Cedars-Sinai Medical Center | 150 | 2023-06-01 | 2026-10-22 |
| mHealth Mindfulness Intervention for Pregnant Black and Latina Women at Risk of Postpartum Depression Stress reduction program 'A', Stress reduction program 'B' - Post Partum Depression, Perinatal Depression | Phase 3 | Active not recruiting | Kaiser Permanente | 600 | 2022-06-14 | 2025-08-05 |
| Calcium Chloride for Prevention of Blood Loss During Intrapartum Cesarean Delivery Calcium chloride, Saline placebo - Uterine Atony, Uterine Atony With Hemorrhage | Phase 3 | Completed | Stanford University | 120 | 2022-04-04 | 2024-06-11 |
| Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial Recombinant Von Willebrand factor, Tranexamic Acid Injection [Cyklokapron] - Von Willebrand Diseases, Postpartum Hemorrhage | Phase 3 | Completed | Nicoletta C Machin | 20 | 2021-06-04 | 2025-10-31 |
| The Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Caesarean Section Tranexamic acid injection, Normal saline placebo - Postpartum Hemorrhage | Phase 3 | Completed | University of Zimbabwe | 1226 | 2021-03-23 | 2023-03-20 |
| Ketamine to Prevent PPD After Cesarean Ketamine 50 MG/ML, Control - Postpartum Depression | Phase 3 | Completed | Washington University School of Medicine | 25 | 2020-11-12 | 2023-01-26 |
| Sublingual vs Intrauterine MISOPROSTOL Plus Oxytocin Infusion for Prevention of Post-cesarean Hemorrhage in High Risk Pregnant Women: A Double-blind Placebo RCT sublingual Misoprostol, Intrauterine Misoprostol - To Compare Efficacy Intrauterine vs Sublingual MISOPROSTOL in Addition to Oxytocin in Reducing Blood Loss of Post-cesarean Section in High Risk Women | Phase 3 | Completed | Department of Medical Services Ministry of Public Health of Thailand | 135 | 2020-10-30 | 2021-09-13 |
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Postpartum Hemorrhage (52) · Depression, Postpartum (21) · Depression (4) · Hemorrhage (4) · Placenta Previa (3) · Puerperal Infection (3) · Anemia (2) · Breast Feeding (2) · Neonatal Sepsis (2) · Pre-Eclampsia (2) · Uterine Inertia (2) · Agnosia (1) · Anemia, Iron-Deficiency (1) · Anxiety Disorders (1)
Female Urogenital Diseases and Pregnancy Complications (78) · Urogenital Diseases (78) · Pregnancy Complications (77) · Pathological Conditions, Signs and Symptoms (58) · Pathologic Processes (56) · Obstetric Labor Complications (52) · Uterine Hemorrhage (52) · Hemorrhage (48) · Depressive Disorder (21) · Mental Disorders (21) · Mood Disorders (21) · Behavior (7) · Hematologic Diseases (5) · Hemic and Lymphatic Diseases (5)
Tranexamic Acid (18) · Oxytocin (17) · Misoprostol (11) · Sodium Chloride (9) · carbetocin (6) · brexanolone (5) · Saline Solution (3) · Ergonovine (2) · Ketamine (2) · iron isomaltoside 1000 (2) · zuranolone (2) · Amoxicillin (1) · Aripiprazole (1) · Aspirin (1) · Azithromycin (1)
Ain Shams University (4) · Cairo University (4) · London School of Hygiene and Tropical Medicine (3) · Supernus Pharmaceuticals, Inc. (3) · Assiut University (2) · Azienda U.S.L. 1 di Massa e Carrara (2) · Biogen (2) · Gynuity Health Projects (2) · KK Women's and Children's Hospital (2) · Lipocine Inc. (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Pharmacosmos A/S (2) · Stanford University (2) · University Hospital, Bordeaux (2) · University of Pittsburgh (2)
United States (21) · Egypt (11) · Canada (4) · China (4) · Denmark (4) · France (4) · India (2) · Israel (2) · Nigeria (2) · Pakistan (2) · Singapore (2) · Spain (2) · Tanzania (2) · United Kingdom (2) · Zambia (2)
Helen Colquhoun, MD (2) · Yariv Yogev, professor (2) · AbdelGany M Hassan (1) · Ahmed N Afifi, MD (1) · Ahmed N Shaker, MD (1) · Alexander J Butwick, F.R.C.A. (1) · Alicia V Aleman, MD (1) · Amgad E. Abou-Gamrah, Ass.Prof. (1) · Amon Agaba, PhD (1) · Amy Brenner (1) · Anne J. Wikkelsoe, MD (1) · Antonio Ragusa, Dr (1) · Arash Afshari, MD (1) · Ban Leong Sng, FANZCA (1)
PMID 33232518, PMID 39162220, PMID 30177236, PMID 33181049, PMID 11207490, PMID 17567419, PMID 19846212, PMID 20056720, PMID 20187965, PMID 20455694, PMID 20884642, PMID 21381158, PMID 22064874, PMID 22565291, PMID 22805300, PMID 22869824, PMID 23215909, PMID 23460682, PMID 23487258, PMID 24880136, PMID 25369200, PMID 25549051, PMID 25586727, PMID 25588587, PMID 26059839, PMID 27188698, PMID 27350226, PMID 28317031, PMID 28413832, PMID 28456509, PMID 28796940, PMID 29558233, PMID 29743045, PMID 29879947, PMID 29945633, PMID 30134136, PMID 30322584, PMID 30514326, PMID 30594227, PMID 30606246, PMID 31962259, PMID 32005192, PMID 32492040, PMID 33169839, PMID 33913639, PMID 34190962, PMID 35038612, PMID 35303924, PMID 36271352, PMID 36724109
2017 (2), 2008 (1), 2009 (1), 2014 (1), D43TW005492 (1), D43TW009343 (1), R01MH053735 (1), R01MH071825 (1), R21MD017396 (1), U24HD092094 (1)