30 completed, 13 recruiting, 3 active not recruiting, 3 terminated. 35 Not applicable, 5 Phase 2, 2 Phase 1, 1 Early Phase 1, 1 Phase 4.
Follow Primary Progressive Aphasia: new trials by email Literature Review of Primary Progressive Aphasia trials Research Report on Primary Progressive Aphasia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stimulating the Aging Brain Using Brain and Sensory Stimulation tACS or multisensory stimulation - Primary Progressive Aphasia | Not applicable | Recruiting | Medical College of Wisconsin | 20 | 2026-06-01 | 2026-06-16 |
| Communication Bridge 3 Study Communication Bridge™, Evidence-Based Impairment Focused - Primary Progressive Aphasia | Phase 2 | Recruiting | University of Chicago | 200 | 2024-08-23 | 2026-06-01 |
| Communication Bridge Pilot Study Communication Bridge - Primary Progressive Aphasia | Not applicable | Active not recruiting | University of Chicago | 12 | 2024-06-28 | 2025-08-07 |
| Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia Psychosocial educational, support group and implementation of strategies - Alzheimer Disease, Dementia | Early Phase 1 | Recruiting | University of Texas at Austin | 120 | 2024-05-21 | 2026-06-10 |
| Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia Active tDCS + Language Therapy, Sham tDCS + Language Therapy - Primary Progressive Aphasia, Logopenic Progressive Aphasia | Phase 2 | Recruiting | Johns Hopkins University | 180 | 2024-02-13 | 2026-05-05 |
| Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling Dementia, Alzheimer Disease | Recruiting | University Health Network, Toronto | 500 | 2023-11-11 | 2025-11-20 | |
| Transmagnetic Stimulation Pilot in Primary Progressive Aphasia Intermittent theta burst stimulation - Primary Progressive Aphasia | Not applicable | Completed | HealthPartners Institute | 3 | 2023-10-02 | 2025-06-03 |
| Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease Computerized Cognitive Training, Active tDCS (tDCS) on DLPFC - Mild Cognitive Impairment, Primary Progressive Aphasia | Not applicable | Terminated | Johns Hopkins University | 5 | 2023-08-10 | 2026-10-21 |
| Speech-Language Treatment With Remotely Supervised Transcranial Direct Current Stimulation in Primary Progressive Aphasia Remotely supervised Transcranial Direct Current Stimulation (RS-tDCS), Remotely supervised sham tDCS (RS-sham-tDCS), Lexical Retrieval Training (LRT) - Primary Progressive Aphasia | Not applicable | Enrolling by invitation | University of Texas at Austin | 10 | 2023-07-10 | 2025-10-08 |
| Primary Progressive Aphasia Multicomponent Language Treatment Study Multicomponent Lexical Retrieval Training (Multi-LRT), Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA), Multicomponent Communication Partner Training (Multi-CPT) - Primary Progressive Aphasia, Semantic Dementia | Not applicable | Enrolling by invitation | University of Texas at Austin | 21 | 2023-05-02 | 2025-10-08 |
| Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia Video-Implemented Script Training for Aphasia (VISTA), Lexical Retrieval Training (LRT) - Primary Progressive Aphasia, Dementia | Not applicable | Recruiting | Stephanie Grasso | 60 | 2023-05-01 | 2026-06-10 |
| Home-Based Exercise in Primary Progressive Aphasia (HEPPA) Home-based multicomponent exercise intervention program - Primary Progressive Aphasia, Neurodegenerative Diseases | Not applicable | Completed | Montreal Heart Institute | 13 | 2023-04-05 | 2025-02-06 |
| Nabilone for Agitation in Frontotemporal Dementia Nabilone, Placebo - Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant | Phase 2 | Terminated | Simon Ducharme, MD | 3 | 2023-03-07 | 2026-07-28 |
| A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM ID:3430931 Active tDCS, individualized language training, Placebo tDCS - Primary Progressive Aphasia | Not applicable | Unknown | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 60 | 2023-02-01 | 2024-09-19 |
| Long-term Effect of TMS in Primary Progressive Aphasia Transcranial Magnetic Stimulation (active), Language therapy, Transcranial Magnetic Stimulation (sham) - Primary Progressive Aphasia, Frontotemporal Dementia | Not applicable | Completed | Hospital San Carlos, Madrid | 63 | 2023-02-01 | 2024-12-18 |
| Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA) Transcranial Direct Current Stimulation (tDCS), Word-Naming Activity - Primary Progressive Aphasia | Phase 2 | Completed | NYU Langone Health | 11 | 2022-12-24 | 2024-09-19 |
| Enhancing Language Function in Aphasia individualized speech-language training, standard language intervention - Aphasia, Acquired, Language Disorders | Not applicable | Recruiting | University of Arizona | 30 | 2022-10-30 | 2024-12-09 |
| Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment, Sham + "Repeat After Me" (RAM) Treatment - Logopenic Progressive Aphasia, Primary Progressive Aphasia | Not applicable | Recruiting | Johns Hopkins University | 60 | 2022-10-15 | 2026-09-09 |
| Identification of Graphic Markers of Neurocognitive Disorders (MG) Identification of Graphic Markers - Alzheimer Disease, Primary Progressive Aphasia | Completed | Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal | 53 | 2022-06-27 | 2024-02-23 | |
| Better Living With Non-memory-led Dementia Better living with non-memory led dementia course - Primary Progressive Aphasia, Frontotemporal Dementia | Not applicable | Completed | University College, London | 31 | 2022-06-21 | 2023-04-27 |
Showing 20 of 53. Sign in to see all of them.
Aphasia, Primary Progressive (53) · Alzheimer Disease (19) · Frontotemporal Dementia (19) · Aphasia (18) · Dementia (13) · Primary Progressive Nonfluent Aphasia (9) · Apraxias (7) · Cognitive Dysfunction (5) · Communication (5) · Language (5) · Neurocognitive Disorders (5) · Aphasia, Broca (4) · Dementia, Vascular (4) · Nerve Degeneration (4) · Neurodegenerative Diseases (4)
Central Nervous System Diseases (53) · Mental Disorders (53) · Nervous System Diseases (53) · Neurobehavioral Manifestations (53) · Neurologic Manifestations (53) · Pathological Conditions, Signs and Symptoms (53) · Signs and Symptoms (53) · Brain Diseases (52) · Language Disorders (51) · Communication Disorders (50) · Speech Disorders (50) · Neurocognitive Disorders (48) · Dementia (40) · Aphasia (35) · Neurodegenerative Diseases (27)
Language Therapy (5) · Transcranial Direct Current Stimulation (5) · Speech Therapy (3) · Transcranial Magnetic Stimulation (3) · Therapeutics (2) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Exercise (1) · Palliative Care (1) · Positron-Emission Tomography (1) · Self-Help Groups (1) · florbetapir (1) · nabilone (1)
Johns Hopkins University (7) · University of Chicago (7) · Mayo Clinic (4) · University of Texas at Austin (4) · University of Pennsylvania (3) · Baycrest (2) · Hospital San Carlos, Madrid (2) · IRCCS Centro San Giovanni di Dio Fatebenefratelli (2) · Medical College of Wisconsin (2) · Northwestern University (2) · University of Arizona (2) · Brigham and Women's Hospital (1) · Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal (1) · Exonhit (1) · HealthPartners Institute (1)
United States (39) · Canada (7) · Spain (3) · Italy (2) · United Kingdom (2) · China (1) · France (1)
Kyrana Tsapkini, PhD (4) · Aneta Kielar, PhD (2) · Emily Rogalski, Ph.D (2) · Emily Roglaski, PhD (2) · Maya L Henry, PhD (2) · Allan Young, Professor (1) · Argye E Hillis, MD, MA (1) · Benzi M Kluger, MD, MS (1) · Charles B. Bernick, MD (1) · Darby Morhardt, PhD (1) · Elias Granadillo (1) · Emily J Rogalski, PhD (1) · Emily Rogalski, Ph.D. (1) · H B Coslett, MD (1) · Jennifer Whitwell, PhD (1)
PMID 33441454, PMID 28713256, PMID 30258975, PMID 33031971, PMID 34006157, PMID 34487043, PMID 34489348, PMID 34875098, PMID 35667724, PMID 35698099, PMID 36662282, PMID 37287321, PMID 37508992, PMID 37821924, PMID 37838080, PMID 37955923, PMID 40070907, PMID 40788648, PMID 41041680, PMID 41812391, PMID 42818139
R01AG055425 (4), 1RF1AG050967-01A1 (1), R01AG075111 (1), R01AG075404 (1), R01AG077444 (1), R01DC012519 (1), R01DC014475 (1), R01DC016291 (1), R01NR016037 (1), R21NS094684 (1), R56AG055425 (1), R56DC016291 (1)