12 completed, 3 recruiting, 1 unknown. 16 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 12, Recruiting 3, Unknown 1 |
| Phase 1 | 3 | Completed 2, Recruiting 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Postoperative Ileus: new trials by email Literature Review of Postoperative Ileus trials Research Report on Postoperative Ileus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery Pyridostigmine Bromide, Placebo - Postoperative Ileus | Phase 2 / Phase 3 | Recruiting | Stefan Holubar MD MS FACS, FASCRS | 50 | 2024-09-03 | 2026-01-07 |
| Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section 0.9%sodium chloride, Dexamethasone - Postoperative Ileus | Phase 1 / Phase 2 | Recruiting | Assiut University | 90 | 2022-12-01 | 2024-12-02 |
| Prucalopride for Postoperative Ileus in Patients Undergoing Robot-assisted Laparoscopic Radical Cystectomy Prucalopride, Placebo - Postoperative Ileus, Bladder Cancer | Phase 2 | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 160 | 2021-09-01 | 2021-08-12 |
| Use of Beetroot Juice to Protect Against Postoperative Ileus Following Colorectal Surgery: BEET IT Study concentrated beetroot juice - Postoperative Ileus | Phase 2 | Recruiting | University Hospital, Ghent | 170 | 2021-03-31 | 2026-02-10 |
| Subcutaneous Methylnaltrexone Versus Placebo for Postoperative Ileus Prevention Methylnaltrexone, Placebo - Postoperative Ileus | Phase 2 | Completed | Ohio State University | 82 | 2019-02-21 | 2021-10-27 |
| Perioperative Dexamethasone on Postoperative Outcome in IBD Dexamethasone, Normal saline - Inflammatory Bowel Diseases, Dexamethasone | Phase 2 | Completed | Jinling Hospital, China | 302 | 2018-06-01 | 2021-02-11 |
| Does Caffeine Enhance Bowel Recovery After Colorectal Surgery? Caffeine Citrate, Water - Postoperative Ileus | Phase 2 | Completed | Hadassah Medical Organization | 70 | 2017-11-02 | 2020-02-11 |
| Lidocaine Infusion in Radical Cystectomy Lidocaine, IV normal saline - Postoperative Ileus | Phase 2 | Completed | Assiut University | 57 | 2017-03-03 | 2018-08-07 |
| Effect of TU-100 in Patients Undergoing Laparoscopic Colectomy Daikenchuto (TU-100), Placebo - Postoperative Ileus | Phase 2 | Completed | Tsumura USA | 69 | 2014-09-01 | 2020-06-19 |
| Prucalopride for Postoperative Ileus in Patients Undergoing Gastrointestinal Surgery Prucalopride, Placebo - Postoperative Ileus | Phase 2 | Completed | Jinling Hospital, China | 110 | 2013-11-01 | 2016-09-30 |
| The Effect of Gum Chewing on Postoperative Ileus After Gynecologic Surgery Chewing gum - Postoperative Ileus | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 294 | 2010-01-01 | 2013-03-14 |
| Effect of TU-100 on Gastrointestinal and Colonic Transit in Humans Daikenchuto (TU-100), Placebo - Postoperative Ileus | Phase 1 / Phase 2 | Completed | Tsumura USA | 60 | 2009-06-01 | 2013-01-14 |
| Safety and Efficacy of IV Infusion of TZP-101 for POI After Major Open Abdominal Surgery 5% dextrose in water, TZP-101 - Postoperative Ileus | Phase 2 | Completed | Tranzyme, Inc. | 267 | 2007-07-01 | 2012-12-07 |
| Trial of Acupuncture for Reduction of Post-Colectomy Ileus Acupuncture, Sham Acupuncture - Postoperative Ileus, Colon Cancer | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 90 | 2006-10-01 | 2015-10-12 |
| A Tolerability and Efficacy Study of TU-100 For The Treatment of Postoperative Ileus Daikenchuto Extract Granules (TU-100) - Postoperative Ileus | Phase 2 | Completed | Tsumura USA | 24 | 2005-12-01 | 2013-07-12 |
| Intravenous (IV) Methylnaltrexone (MNTX) in the Prevention of Post-Operative Ileus IV Methylnaltrexone (MNTX), Placebo - Postoperative Ileus | Phase 2 | Completed | Bausch Health Americas, Inc. | 65 | 2003-07-01 | 2019-11-27 |
Colonic Neoplasms (1) · Gastrointestinal Diseases (1) · Ileus (1) · Inflammatory Bowel Diseases (1) · Pain, Postoperative (1) · Postoperative Complications (1) · Postoperative Nausea and Vomiting (1) · Urinary Bladder Neoplasms (1)
Digestive System Diseases (4) · Gastrointestinal Diseases (3) · Intestinal Diseases (3) · Neoplasms (2) · Neoplasms by Site (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Colonic Diseases (1) · Colorectal Neoplasms (1) · Digestive System Neoplasms (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Gastroenteritis (1) · Gastrointestinal Neoplasms (1) · Intestinal Neoplasms (1)
12,13-dihydro-N-methyl-6,11,13-trioxo-5H-benzo(4,5)cyclohepta(1,2-b)naphthalen-5,12-imine (3) · Dexamethasone (2) · Saline Solution (2) · Water (2) · dai-kenchu-to (2) · methylnaltrexone (2) · prucalopride (2) · Acupuncture Therapy (1) · Chewing Gum (1) · Glucose (1) · Lidocaine (1) · Pyridostigmine Bromide (1) · Sodium Chloride (1) · caffeine citrate (1) · ulimorelin (1)
Tsumura USA (3) · Assiut University (2) · Jinling Hospital, China (2) · Bausch Health Americas, Inc. (1) · Hadassah Medical Organization (1) · Johns Hopkins University (1) · Memorial Sloan Kettering Cancer Center (1) · Ohio State University (1) · Stefan Holubar MD MS FACS, FASCRS (1) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (1) · Tranzyme, Inc. (1) · University Hospital, Ghent (1)
United States (9) · China (2) · Egypt (2) · Belgium (1) · India (1) · Israel (1) · Romania (1)
Jianfeng Gong, MD (2) · Amelia M Jernigan, MD (1) · Catherine A Sewell, MD, MPH (1) · Christine Jensen, M.D., M.P.H. (1) · Gary Deng, MD, PhD (1) · Grace Chen, MD (1) · Michael Camilleri, MD (1) · Noam Shussman, MD (1) · Shunji Mochida, PhD (1) · Stefan D Holubar (1) · Tage Ramakrishna, MD (1)
PMID 25147092, PMID 26880227, PMID 30921979, PMID 33749741, PMID 33900493, PMID 34798295