15 completed, 15 not yet recruiting, 11 recruiting, 1 active not recruiting. 18 Not applicable, 3 Phase 4, 2 Phase 3, 1 Phase 2.
Follow Postoperative Delirium (POD): new trials by email Literature Review of Postoperative Delirium (POD) trials Research Report on Postoperative Delirium (POD)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immunonutrition and Neuromonitoring for Postoperative Delirium in Gynecologic Oncology Preoperative Immunonutritional Scoring and Intraoperative Neuromonitoring - Postoperative Delirium (POD), Gynecologic Cancers | Recruiting | Elazıg Fethi Sekin Sehir Hastanesi | 80 | 2026-10-01 | 2026-10-16 | |
| Prediction and Prevention of Postoperative Mortality and Morbidity Personalized CPC Prehabilitation, Cognitive Training, Meditation - Dementia, Postoperative Delirium (POD) | Not applicable | Not yet recruiting | University of Pittsburgh | 1200 | 2026-10-01 | 2026-09-25 |
| Effect of Preoperative Ultrasound-Guided Stellate Ganglion Block on Postoperative Delirium in Older Adults Undergoing Elective Peripheral Endovascular Intervention ropivacaine - Postoperative Delirium (POD), Peripheral Arterial Disease | Not applicable | Not yet recruiting | Assiut University | 168 | 2026-10-01 | 2026-09-29 |
| Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery Remimazolam Besylate, propofol - Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch | Phase 4 | Not yet recruiting | Seoul National University Hospital | 80 | 2026-10-01 | 2026-09-17 |
| Heart Rate Variability Changes and Postoperative Delirium After Major Abdominal Surgery Perioperative Heart Rate Variability Changes - Postoperative Delirium (POD), Heart Rate Variability (HRV) | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 500 | 2026-09-21 | 2026-09-28 | |
| Effect of Eye Mask Use on Sleep Quality and Delirium After CABG Surgery Eye Mask - Coronary Artery Disease, Sleep Quality | Not applicable | Not yet recruiting | Munzur University | 100 | 2026-09-15 | 2026-08-17 |
| Preoperative Breathing Exercise Training and Postoperative Delirium After Robotic Radical Prostatectomy Preoperative Deep Breathing Exercise Training - Postoperative Delirium (POD), Prostate Cancer | Not applicable | Not yet recruiting | ALİ DEMİRTAŞ | 50 | 2026-09-01 | 2026-08-14 |
| Perioperative Biomarkers and Postoperative Delirium in Older Adults Undergoing Abdominal Cancer Surgery Perioperative Biomarker Assessment, Confusion Assessment Method (CAM) - Postoperative Delirium (POD), Abdominal Neoplasms | Recruiting | Fatma Cigdem Ozakin | 100 | 2026-09-01 | 2026-10-05 | |
| Perioperative Dezocine Administration and Postoperative Delirium in Elderly Cardiac Surgery Patients Dezocine, Normal Saline (NS) - Postoperative Delirium (POD) | Not applicable | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 640 | 2026-09-01 | 2026-08-17 |
| Maintaining Intraoperative Mean Arterial Pressure at 85 mmHg or Higher to Reduce Postoperative Delirium in Older Patients With Arterial Hypertension Having Non-cardiac Surgery MAP at 85 mmHg or higher (intervention group), MAP at 65 mmHg or higher (control group) - Postoperative Delirium (POD), Intraoperative Hypotension | Not applicable | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 3432 | 2026-08-21 | 2026-08-25 |
| Ketofol Versus Ketodex for POD Prophylaxis in Elderly Cancer Surgery Group ketofol, Group ketodex, Group Control - Postoperative Delirium (POD) | Phase 3 | Recruiting | Cairo University | 180 | 2026-07-01 | 2026-06-04 |
| Intranasal Insulin for Postoperative Delirium in Older Patients With T2DM Insulin, human, Intranasal Normal Saline (Placebo) - Postoperative Delirium (POD) | Not applicable | Not yet recruiting | Weidong Mi | 210 | 2026-07-01 | 2026-07-22 |
| Dexmedetomidine Nasal Spray on Postoperative Delirium in Elderly Thoracoscopic Lung Resection Patients Dexmedetomidine hydrochloride nasal spray, Placebo - Postoperative Delirium (POD) | Phase 4 | Not yet recruiting | Sichuan Provincial People's Hospital | 264 | 2026-06-01 | 2026-05-12 |
| Sex-Dependent Risk of Postoperative Delirium and Mediating Effects of Family Visits Postoperative Delirium (POD), Sex Differences | Recruiting | Julian Rössler | 471 | 2026-05-05 | 2026-06-01 | |
| MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES) Dexmedetomidine, Placebo - Major Abdominal Surgery, Postoperative Delirium (POD) | Phase 2 / Phase 3 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 400 | 2026-05-01 | 2026-04-20 |
| A Phase II Clinical Two-Stage Study of Transcranial Magnetic Stimulation in Preventing Postoperative Delirium in Elderly Patients After Urological Surgery Transcranial Magnetic Stimulation Device - Postoperative Delirium (POD), Prostate Cancer | Not applicable | Not yet recruiting | Zhejiang University | 220 | 2026-03-20 | 2026-03-18 |
| Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium and Negative Emotions in Patients Undergoing Cardiac Surgery Active taVNS, Sham taVNS Group - Postoperative Delirium (POD), Postoperative | Not applicable | Not yet recruiting | Chinese PLA General Hospital | 270 | 2026-02-28 | 2026-03-17 |
| Proactive Temperature Management in CRS-HIPEC for Prevention of Delirium Proactive Goal-Directed Temperature Management, Standard Reactive Temperature Management - Pseudomyxoma Peritonei, Postoperative Delirium (POD) | Not applicable | Not yet recruiting | Aerospace Center Hospital | 174 | 2026-02-01 | 2026-01-30 |
| Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery Target Controlled Infusion, Total Intravenous Anesthesia(TIVA) - Postoperative Delirium (POD), Postoperative Pain | Not applicable | Completed | Istanbul University - Cerrahpasa | 63 | 2026-01-14 | 2026-09-09 |
| GENECARD - the Use of Genetic, Epigenetic, Metabolomic, Proteomic and Microbiotic Markers, Image and Voice Biomarker Analyses, and Pre- and Intraoperative Clinical Data - to Predict Early Complications After Cardiac Surgery. Multi-Omics Data and Clinical Data Collection - Postoperative Delirium (POD), Postoperative Bleeding | Not yet recruiting | Medical University of Gdansk | 3000 | 2026-01-01 | 2026-01-15 |
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Emergence Delirium (46) · Postoperative Cognitive Complications (4) · Frailty (3) · Postoperative Complications (3) · Acute Kidney Injury (2) · Cognitive Dysfunction (2) · Depression (2) · Diabetes Mellitus (2) · Hip Fractures (2) · Pain, Postoperative (2) · Prostatic Neoplasms (2) · Abdominal Neoplasms (1) · Aneurysm, Aortic Arch (1) · Anxiety Disorders (1) · Atrial Fibrillation (1)
Confusion (46) · Delirium (46) · Mental Disorders (46) · Nervous System Diseases (46) · Neurobehavioral Manifestations (46) · Neurologic Manifestations (46) · Pathologic Processes (46) · Pathological Conditions, Signs and Symptoms (46) · Signs and Symptoms (46) · Neurocognitive Disorders (45) · Postoperative Complications (43) · Cardiovascular Diseases (6) · Vascular Diseases (6) · Cognition Disorders (5) · Neoplasms (5)
Propofol (3) · Control Groups (2) · Dexmedetomidine (2) · Saline Solution (2) · (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol (1) · Acupuncture Therapy (1) · Anesthesia (1) · Cognitive Training (1) · Comorbidity (1) · Ephedrine (1) · Esketamine (1) · Insulin (1) · Intraoperative Neurophysiological Monitoring (1) · Laboratories (1) · Magnetic Resonance Spectroscopy (1)
Chinese PLA General Hospital (6) · ALİ DEMİRTAŞ (1) · Aerospace Center Hospital (1) · Ankara Ataturk Sanatorium Training and Research Hospital (1) · Aslıhan Güleç (1) · Assiut University (1) · Cairo University (1) · Charite University, Berlin, Germany (1) · Chinese Academy of Medical Sciences, Fuwai Hospital (1) · Elazıg Fethi Sekin Sehir Hastanesi (1) · Fatih Sultan Mehmet Training and Research Hospital (1) · Fatma Cigdem Ozakin (1) · First Affiliated Hospital of Kunming Medical University (1) · First Affiliated Hospital of Zhejiang University (1) · Istanbul University - Cerrahpasa (1)
China (19) · Turkey (Türkiye) (10) · Germany (2) · Switzerland (2) · Czechia (1) · Egypt (1) · Netherlands (1) · Poland (1) · South Korea (1) · Sweden (1) · United States (1)
Ali Okuyan, MD (1) · Claudia Spies, MD Prof. (1) · Kowalik M Kowalik, MD, PhD, Dsc (1) · Lingling Ding, Doctor (1) · Luzius Steiner, Prof. Dr. med. (1) · Maciej M Kowalik, MD, PhD, Dsc (1) · Maria Lampi, PhD (1) · Senthilkumar Sadhasivam, MD, MPH, MBA (1) · Tianlong Wang, Doctor (1) · Ting Li, MD. PhD (1)
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