13 not yet recruiting, 11 completed, 10 unknown, 5 recruiting. 23 Not applicable, 8 Phase 4, 4 Phase 2, 4 Phase 3, 1 Early Phase 1.
Follow Post Operative Pain, Acute: new trials by email Literature Review of Post Operative Pain, Acute trials Research Report on Post Operative Pain, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery Combogesic® tablets, Acetaminophen 500mg, Placebo - Post Operative Pain, Acute | Phase 3 | Not yet recruiting | AFT Pharmaceuticals, Ltd. | 180 | 2026-10-01 | 2026-07-01 |
| The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration Dexamethasone IV injection, Dexamethasone Capsule, Placebo IV administration - Post Operative Pain, Acute, Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 40 | 2026-10-01 | 2026-09-21 |
| Maneuvers to Reduce Laparoscopic Pain Smoke Evacuation Group, Recruitment Breath Group, Control Group - Laparoscopic Surgery, Post Operative Pain, Acute | Not applicable | Not yet recruiting | Henry Ford Health System | 150 | 2026-10-01 | 2026-09-09 |
| Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation sonically activated irrigation, laser activated irrigation, conventional needle irrigation - Apical Periodontitis, Post Operative Pain, Acute | Not applicable | Not yet recruiting | University Ghent | 183 | 2026-10-01 | 2026-10-20 |
| Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery Suzetrigine, Opioid standard care pain medicine - Knee Arthroplasty, Total, Post Operative Pain, Acute | Phase 4 | Not yet recruiting | Endeavor Health | 100 | 2026-09-01 | 2026-09-02 |
| Comparıson of Analgesıc Effıcacy of Dıfferent Volumes of Serratus Posterior Superıor Intercostal Plane Block After Modıfıed Radıcal Mastectomy Surgery Serratus Posterior Superior Intercostal Plane (SPSIP) block 40 ml of 0.1875% bupivacaine, Serratus Posterior Superior Intercostal Plane (SPSIP) 50 ml of 0.15% bupivacaine, Serratus Posterior Superior Intercostal Plane (SPSIP) 30 ml of 0.25% bupivacaine - Modified Radical Mastectomy, Post Operative Pain, Acute | Not applicable | Not yet recruiting | Cumhuriyet University | 90 | 2026-08-25 | 2026-08-25 |
| Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Single-Visit Root Canal Treatment Sodium Hypochlorite Irrigation - Post Operative Pain, Acute | Not applicable | Not yet recruiting | College of Physicians and Surgeons Pakistan | 116 | 2026-07-05 | 2026-06-01 |
| Analgesic Efficacy of Combined PECS II and PIP Block Versus Thoracic Paravertebral Block Post-Mastectomy Combined PECS II and Superficial PIP Block, Thoracic paravertebral block (TPVB) - Acute Pain, Post Operative Analgesia | Not applicable | Recruiting | Dharmais National Cancer Center Hospital | 72 | 2026-06-29 | 2026-07-31 |
| Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part A Morphine provided via oral PCA, Morphine provided via oral PCA + morphine administered at a scheduled regimen - Post Operative Analgesia, Rebound Pain | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire Vaudois | 100 | 2026-06-01 | 2026-06-24 |
| Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part B Morphine provided via oral PCA, Morphine provided via oral PCA + morphine administered at a scheduled regimen - Post Operative Analgesia, Rebound Pain | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire Vaudois | 100 | 2026-06-01 | 2026-06-24 |
| Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery Ketamine group, Control Group - Cardiac Anaesthesia, Chronic Pain | Not applicable | Not yet recruiting | Bursa City Hospital | 100 | 2026-04-15 | 2026-03-24 |
| To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless AH-Plus Epoxy Resin Sealer, bioceramic sealer - Post Operative Pain, Acute, Irreversible Pulpitis | Phase 2 / Phase 3 | Not yet recruiting | Jaweria Gul Keyani | 60 | 2026-04-01 | 2026-01-08 |
| Comparison Between the Analgesic Effect of Fascia Transversalis Block vs Caudal Block Caudal Block Anesthesia, Fascia Transversalis Block - Post Operative Pain, Acute | Phase 3 | Completed | Cairo University | 50 | 2025-11-20 | 2026-04-17 |
| Comparison of Pericapsular Nerve Group (PENG) Block With a Combined Femoral, Sciatic, Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia in Secondary Total Hip Arthroplasty; (REVPET) Pericapsular nerve group (PENG) block with 0.75% ropivacaine guided by ultrasound, Femoral, sciatic and lateral femoral cutaneous nerve block with 0.375% ropivacaine - Hip Arthroplasty Replacement, Post Operative Analgesia | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire Vaudois | 50 | 2025-09-30 | 2025-09-22 |
| Supra Inguinal Fascia Iliaca Block as Rescue Analgesia Following Total Hip Arthroplasty Ultrasound guided supra inguinal fascia iliaca block, Placebo Injection, Surgical and anesthetic protocol - Hip Arthroplasty, Total, Post Operative Pain, Acute | Not applicable | Recruiting | Institut Mutualiste Montsouris | 310 | 2025-09-22 | 2025-09-25 |
| Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery Bilateral ultrasound guided Serratus Posterior Superior Plane Block, IV morphine patient-controlled analgesia, Bilateral ultrasound guided Sham Block - Cardiac Surgery, Post Operative Pain, Acute | Not applicable | Recruiting | Ondokuz Mayıs University | 50 | 2025-09-13 | 2026-07-02 |
| Continuous Epidural With Dexmedetomidine Adjuvant in Gynecologic Laparotomy Dexmedetomidine & Bupivacaine., Bupivacain - Post Operative Pain, Acute, Chronic Post Surgical Pain | Phase 4 | Completed | Udayana University | 62 | 2025-08-21 | 2026-03-25 |
| Intraperitoneal Lidocaine and Bupivacaine for Postoperative Pain After Laparoscopic Surgery Lidocaine, Placebo Normal Saline (NS), Bupivacaine - Abdominal Laparoscopic and/or Robotic Surgery, Local Anasthesia | Not applicable | Completed | Misr University for Science and Technology | 64 | 2025-08-06 | 2026-08-20 |
| Effect of Probiotics, Double Antibiotic Paste, and Calcium Hydroxide on Postoperative Pain in Irreversible Pulpitis: A Randomized Trial Probiotic - Root Canal Treatment, Irreversible Pulpitis With Apical Periodontitis | Not applicable | Completed | Dow University of Health Sciences | 75 | 2025-06-01 | 2025-12-08 |
| Comparison Between Dexametidomedine\Bupivacaine and Plain Bupivacaine in Superior Trunk Block for Arthroscopic Shoulder Surgeries dexametedomidine, Bupivacain - Post Operative Pain, Acute, Arthroscopic Shoulder Surgery | Not applicable | Completed | Ain Shams University | 40 | 2025-01-20 | 2025-07-01 |
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Pain, Postoperative (40) · Agnosia (3) · Pain (2) · Acute Pain (1) · Breast Neoplasms (1) · Chronic Pain (1) · Genital Diseases, Female (1) · Periapical Periodontitis (1) · Periodontitis (1) · Pneumoperitoneum (1) · Postoperative Complications (1)
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