18 completed, 11 unknown, 8 not yet recruiting, 3 recruiting. 32 Not applicable, 1 Early Phase 1, 1 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 32 | Completed 12, Unknown 10, Not yet recruiting 7, Recruiting 2, Withdrawn 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 1 | 1 | Unknown 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Not yet recruiting 1 |
Follow Post-stroke Depression: new trials by email Literature Review of Post-stroke Depression trials Research Report on Post-stroke Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study on the Preventive Effect of Electroacupuncture Combined With Dexmedetomidine in Post-stroke Depression Dexmedetomidine, Electropuncture, Normal Saline (NS) - Post-stroke Depression | Phase 4 | Not yet recruiting | Min Su | 231 | 2026-08-01 | 2026-07-31 |
| Benson Relaxation for Anxiety, Depression, and Insomnia After Stroke Benson Relaxation Technique, Structured Health Education - Ischemic Stroke, Acute, Post-stroke Anxiety | Not applicable | Completed | Changchun University of Traditional Chinese Medicine | 84 | 2026-07-28 | 2026-09-29 |
| Nursing Health Education to Improve Functionality and Quality of Life After Ischemic Stroke Health education Program - Ischemia Stroke, Post-stroke Depression | Not applicable | Not yet recruiting | University of Santiago de Compostela | 70 | 2026-06-01 | 2026-01-15 |
| Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors Tele-delivered Behavioral Activation by lay counselors after Stroke (Tele-BA-S), Treatment as Usual - Post-stroke Depression, Subthreshold Depression | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 350 | 2026-04-10 | 2026-04-28 |
| Intervention Study of Virtual Reality-Based Mindfulness-Based Cognitive Therapy (VR-MBCT) Combined With Adaptive tDCS Modulation for Post-Stroke Depression Virtual Reality Mindfulness-Based Cognitive Therapy (Active VR-MBCT), Active transcranial Direct Current Stimulation (Active tDCS), Sham Virtual Reality Mindfulness Program (Sham VR-MBCT) - Post-stroke Depression | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 120 | 2026-02-10 | 2026-02-20 |
| Effects of Robotic Rehabilitation on Quality of Life, Mood, and Fatigue After Stroke RoboGait® Robotic Gait Training, Treadmill Walking Training - Stroke, Post-stroke Depression | Not applicable | Not yet recruiting | Meltem Gunes Akinci | 36 | 2026-01-15 | 2026-01-26 |
| Construction and Clinical Validation Study of a Prediction Model for Depression After Ischemic Stroke Group patients based on whether they have been diagnosed with PSD. - Post-stroke Depression | Recruiting | Min Su | 488 | 2025-11-01 | 2026-02-05 | |
| Physical Capacity Building for Chronic Stroke Physical capacity training for chronic stroke - building aerobic capacity and muscle strength - Stroke, Post-stroke Depression | Not applicable | Recruiting | Medical University of South Carolina | 76 | 2025-08-05 | 2025-12-08 |
| Efficacy of Remote Ischemic Conditioning in Preventing Post-Stroke Depression RIC, Sham-RIC - Post-stroke Depression, Remote Ischemic Conditioning | Not applicable | Not yet recruiting | Xuanwu Hospital, Beijing | 240 | 2025-04-10 | 2025-04-10 |
| The Research Team Aims to Elucidate the Impact of ITBS (intermittent Theta Burst Stimulation) on the HPA Axis and Post-stroke Negative Emotions/depression by Conducting Human Experiments That Target Various Brain Regions. iTBS - Stroke, Post-stroke Depression | Not applicable | Not yet recruiting | The Second Affiliated Hospital of Kunming Medical University | 60 | 2025-04-01 | 2025-03-28 |
| Investigating How the RECT Impacts Brain Functional States Through the ACC-cerebellar Loop Left cerebellar TMS stimulation combined with the RECT task, Right cerebellar TMS stimulation combined with the RECT task, Midline cerebellar TMS stimulation combined with the RECT task - Post-stroke Depression | Not applicable | Not yet recruiting | The Second Affiliated Hospital of Kunming Medical University | 100 | 2025-03-30 | 2025-04-04 |
| To Explore the Neural Processing Mechanism of Cerebellum Involved in Facial Expression Recognition Based on Transcranial Magnetic Stimulation TMS - Post-stroke Depression | Not applicable | Not yet recruiting | The Second Affiliated Hospital of Kunming Medical University | 160 | 2025-03-25 | 2025-03-06 |
| Transcranial Direct Current Stimulation on Post Stroke Depression tDCS, Conventional treatment - Post-stroke Depression | Not applicable | Completed | Riphah International University | 60 | 2024-10-25 | 2026-05-08 |
| Efficacy and Safety of Auricular Acupuncture in Treating Insomnia Post-stroke Auricular Acupuncture needles, Sham Auricular Acupuncture needles - Insomnia, Secondary, Post-stroke Depression | Not applicable | Unknown | University of Medicine and Pharmacy at Ho Chi Minh City | 60 | 2024-03-01 | 2024-10-01 |
| SCED - Wisdom Enhancement for Post-Stroke Depression Timeline Intervention - Post-stroke Depression | Not applicable | Completed | University of East Anglia | 3 | 2023-09-01 | 2025-09-30 |
| Efficacy of Repeated Transcranial Magnetic Stimulation Based on Near-infrared Imaging in Patients With Post-stroke Depression rTMS treatment, conventional treatment - Stroke, Post-stroke Depression | Not applicable | Completed | Dingqun Bai | 28 | 2023-06-01 | 2024-12-09 |
| Effects and Central Mechanism of Electroacupuncture and MRI-navigated rTMS for PSD electro-acupuncture, MRI-navigated rTMS - Post-stroke Depression, Healthy | Not applicable | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 64 | 2022-10-22 | 2023-03-23 |
| Developing an EEG Probe for Studying and Modulating Cognitive Control Transcranial Electrical stimulation, Transcutaneous direct current stimulation - Post-stroke Depression | Not applicable | Completed | University of Cincinnati | 30 | 2022-09-28 | 2024-06-27 |
| Efficacy of Acupuncture at Acupoints Group Around the Base of Skull for Post-Stroke Depression Electroacupuncture, Sham acupuncture - Post-stroke Depression | Not applicable | Unknown | China Academy of Chinese Medical Sciences | 98 | 2022-05-06 | 2023-09-06 |
| Efficacy of Accelerated Repetitive Transcranial Magnetic Stimulation on Patients With Post-stroke Depression The Magstim Rapid2 Plus Magnetic Stimulator (Magstim, Whitland, Dyfed, UK) - Post-stroke Depression | Not applicable | Completed | Ankara City Hospital Bilkent | 24 | 2022-02-07 | 2023-12-05 |
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Stroke (11) · Depression (8) · Anxiety Disorders (4) · Ischemic Stroke (2) · Cognitive Dysfunction (1) · Dementia, Vascular (1) · Fatigue (1) · Health Education (1) · Motor Activity (1) · Phobic Disorders (1) · Sleep Initiation and Maintenance Disorders (1)
Nervous System Diseases (14) · Brain Diseases (13) · Cardiovascular Diseases (13) · Central Nervous System Diseases (13) · Cerebrovascular Disorders (13) · Vascular Diseases (13) · Behavior (8) · Behavioral Symptoms (8) · Mental Disorders (7) · Neurocognitive Disorders (2) · Adherence Interventions (1) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Cognition Disorders (1) · Dementia (1)
Acupuncture Therapy (3) · Standard of Care (2) · Transcranial Direct Current Stimulation (2) · Dexmedetomidine (1) · Electroacupuncture (1) · Fluoxetine (1) · Ketamine (1) · Maraviroc (1) · Medicine, Chinese Traditional (1) · Muscle Strength (1) · Pain Measurement (1) · Saline Solution (1) · Therapeutics (1) · Transcranial Magnetic Stimulation (1)
The Second Affiliated Hospital of Kunming Medical University (3) · Min Su (2) · Xuanwu Hospital, Beijing (2) · Zhujiang Hospital (2) · Amelia Adcock (1) · Ankara City Hospital Bilkent (1) · BDH-Klinik Hessisch Oldendorf (1) · Cathay General Hospital (1) · Centre Hospitalier St Anne (1) · Changchun University of Traditional Chinese Medicine (1) · China Academy of Chinese Medical Sciences (1) · Chinese University of Hong Kong (1) · Dingqun Bai (1) · Fatih Sultan Mehmet Training and Research Hospital (1) · First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (1)
China (13) · United States (6) · Turkey (Türkiye) (3) · Germany (2) · Taiwan (2) · France (1) · Israel (1) · Japan (1) · Netherlands (1) · Norway (1) · Pakistan (1) · United Kingdom (1) · Vietnam (1)
Alexandra L Terrill, PhD (1) · Arzu Atici, MD (1) · Audny Anke, Professor (1) · Benjamin Stahl, PhD (1) · Dingqun Bai (1) · Duygu Silte Karamanlioglu, MD (1) · Ercan T Hassan, PGDIP CBT (1) · Feyza Unlu Ozkan, Assoc Prof (1) · Gulcan Ozturk, MD (1) · Haiqing Song, doctor (1) · Hong Gao (1) · Ilknur Aktas, Prof (1) · Jennifer Beauchamp, PhD, RN (1)
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R01HD114673 (1)