Construction and Clinical Validation Study of a Prediction Model for Depression After Ischemic Stroke

NCT07294274 — Recruiting, 488 participants, Min Su

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Registry	NCT07294274
Status	Recruiting
Study type	Observational
Enrollment	488 (Estimated)
Sponsor	Min Su (Other); collaborators: Chongqing Traditional Chinese Medicine Hospital
Conditions	Post-stroke Depression
Interventions	Group patients based on whether they have been diagnosed with PSD. (Diagnostic test)
Dates	start 2025-11-01, primary completion 2026-07-20 (estimated), completion 2026-07-20 (estimated), first posted 2025-12-19, last updated 2026-02-05
Locations	1 site in China

-Summary

Post-stroke depression (PSD) is the most common neuropsychiatric disorder after a stroke, with an incidence rate of 20% to 60%. PSD is not only associated with higher mortality rates, poorer recovery, more obvious cognitive impairments, greater economic burdens, and lower quality of life, but also brings additional medical expenses and care pressure to families. Society also needs to bear higher medical costs. Currently, the early diagnosis of PSD is difficult, which may lead to poor prognosis after stroke. This study aims to utilize machine learning technology to integrate multi-dimensional indicators of patients with ischemic stroke, establish a risk prediction model for PSD, and assist in early, accurate, and individualized assessment of PSD risk in clinical practice.

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+Arms and interventions

Arm	Type	Interventions	Description
The group of PSD		Diagnostic Test: Group patients based on whether they have been diagnosed with PSD.	The patient was diagnosed with PSD.
NPSD		Diagnostic Test: Group patients based on whether they have been diagnosed with PSD.	The patient was not diagnosed with PSD.

Group patients based on whether they have been diagnosed with PSD. (Diagnostic test): Group patients based on whether they have been diagnosed with PSD.

+Outcome measures

Primary outcomes

The number of post-stroke depression (PSD) that occurs 3 months after stroke [3 months after stroke]

+Eligibility

Sex: All

Inclusion Criteria:

* Patients with acute ischemic stroke;
* Admission within 7 days of symptom onset;
* The patient and/or the family members sign a written informed consent form.

Exclusion Criteria:

* Confusion of consciousness,severe cognitive impairment, etc
* Individuals with a history of depression, schizophrenia, bipolar disorder, etc;
* Individuals unable to participate in neuropsychological examinations due to hearing im pairments, lack of coordination, or neurological deficits, including se vere aphasia.

+Locations (1)

Facility	City	Country	Status
The First Affiliated Hospital of Chongqing Medical University	Chongqing	China	Recruiting