11 completed, 2 terminated, 2 unknown, 1 active not recruiting. 16 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Completed 11, Terminated 2, Unknown 2, Active not recruiting 1 |
| Phase 2 | 4 | Completed 2, Terminated 1, Unknown 1 |
Follow Pleural Effusion: new trials by email Literature Review of Pleural Effusion trials Research Report on Pleural Effusion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase Ⅲ Clinical Study of Combined Cisplatin Versus Placebo Combined With Intracavitary Cisplatin Injection in the Treatment of Malignant Pleural Effusions ENDOSTAR，cisplatin, Placebo , cisplatin - Malignant Pleural Effusion | Phase 3 | Active not recruiting | Jiangsu Simcere Pharmaceutical Co., Ltd. | 290 | 2021-07-28 | 2026-01-02 |
| Use of Vasopressin Following the Fontan Operation Vasopressin, Normal Saline - Pleural Effusion, Single-ventricle | Phase 2 / Phase 3 | Completed | Wake Forest University Health Sciences | 12 | 2016-12-01 | 2024-10-24 |
| Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion Iodopovidone solution, Talc - Malignant Pleural Effusion | Phase 3 | Completed | Chiang Mai University | 60 | 2015-11-01 | 2020-01-23 |
| COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial) Colchicine, Placebo - Cardiac Surgery, Post-pericardiotomy Syndrome | Phase 3 | Unknown | Maria Vittoria Hospital | 360 | 2012-03-01 | 2014-07-01 |
| Cryobiopsy or Forceps Biopsy During Semirigid Thoracoscopy: a Comparative Study cryobiopsy (Autoclavable cryoprobe 20416-032 (ERBE, Germany) Flexible FB-55CD-1 Olympus forceps - Pleural Effusion, Pleural Diseases | Phase 2 / Phase 3 | Completed | The University Clinic of Pulmonary and Allergic Diseases Golnik | 40 | 2011-11-01 | 2015-09-10 |
| Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients Abnoba Viscum F 20mg - Malignant Pleural Effusion | Phase 3 | Completed | Abnoba Korea | 68 | 2011-01-01 | 2014-07-23 |
| Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer Bevacizumab, Cisplatin - Malignant Pleural Effusion | Phase 3 | Completed | Chinese PLA General Hospital | 72 | 2009-08-01 | 2015-03-25 |
| Anemia Treatment for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy Darbepoetin alfa, Placebo - Non-Small Cell Lung Cancer, Anemia | Phase 3 | Terminated | Amgen | 2549 | 2009-07-17 | 2022-11-30 |
| A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions Thoracoscopy and Pleurx, Thoracoscopy - Malignant Pleural Effusions | Phase 3 | Completed | Singapore General Hospital | 120 | 2008-09-01 | 2017-02-10 |
| Tenecteplase (TNK) for Loculated Pleural Effusions in Patients With Malignancy normal saline, TNK (Tenecteplase) - Pleural Effusion | Phase 2 / Phase 3 | Terminated | Kaiser Permanente | 20 | 2008-01-01 | 2026-04-14 |
| Rigid Versus Semirigid Thoracoscopy in Diagnosing Pleural Diseases: a Randomized Study semirigid thoracoscopy, rigid thoracoscopy - Pleural Diseases | Phase 3 | Completed | Aleš Rozman | 84 | 2008-01-01 | 2011-11-11 |
| Dornase Alfa and Urokinase for Kids With Pleural Empyema Urokinase and Dornase alfa, Urokinase - Pleural Empyema | Phase 2 / Phase 3 | Unknown | Azienda Ospedaliera di Padova | 94 | 2007-10-01 | 2008-05-12 |
| Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma talc, therapeutic thoracoscopy, therapeutic videothoracoscopy - Malignant Mesothelioma, Metastatic Cancer | Phase 3 | Completed | Papworth Hospital NHS Foundation Trust | 196 | 2003-09-01 | 2013-06-28 |
| Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer talc, dyspnea management - Metastatic Cancer, Pulmonary Complications | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 67 | 2002-05-01 | 2016-07-04 |
| Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions bleomycin sulfate, doxycycline, talc - Metastatic Cancer | Phase 3 | Completed | Eastern Cooperative Oncology Group | 480 | 1997-01-10 | 2023-06-22 |
| Talc in Treating Patients With Malignant Pleural Effusion talc, Talc - Metastatic Cancer | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 501 | 1994-12-01 | 2016-06-28 |
Pleural Effusion, Malignant (10) · Neoplasm Metastasis (4) · Carcinoma, Non-Small-Cell Lung (2) · Neoplasms (2) · Pleural Diseases (2) · Anemia (1) · Atrial Fibrillation (1) · Empyema, Pleural (1) · Lung Neoplasms (1) · Mesothelioma, Malignant (1) · Pericardial Effusion (1) · Postpericardiotomy Syndrome (1) · Solitary Fibrous Tumor, Pleural (1) · Univentricular Heart (1)
Respiratory Tract Diseases (16) · Pleural Diseases (14) · Neoplasms by Site (10) · Pleural Neoplasms (10) · Respiratory Tract Neoplasms (10) · Thoracic Neoplasms (10) · Neoplasms (9) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Neoplastic Processes (4) · Lung Diseases (3) · Bronchial Neoplasms (2) · Carcinoma, Bronchogenic (2) · Cardiovascular Diseases (2)
Talc (5) · Cisplatin (2) · Saline Solution (2) · Arginine (1) · Arginine Vasopressin (1) · Bevacizumab (1) · Bleomycin (1) · Colchicine (1) · Darbepoetin alfa (1) · Doxycycline (1) · Povidone-Iodine (1) · Tenecteplase (1) · Thoracoscopy (1) · Urokinase-Type Plasminogen Activator (1) · Vasopressins (1)
Alliance for Clinical Trials in Oncology (2) · Abnoba Korea (1) · Aleš Rozman (1) · Amgen (1) · Azienda Ospedaliera di Padova (1) · Chiang Mai University (1) · Chinese PLA General Hospital (1) · Eastern Cooperative Oncology Group (1) · Jiangsu Simcere Pharmaceutical Co., Ltd. (1) · Kaiser Permanente (1) · Maria Vittoria Hospital (1) · Papworth Hospital NHS Foundation Trust (1) · Singapore General Hospital (1) · The University Clinic of Pulmonary and Allergic Diseases Golnik (1) · Wake Forest University Health Sciences (1)
United States (5) · China (3) · Italy (3) · Slovenia (3) · Canada (2) · South Korea (2) · United Kingdom (2) · Argentina (1) · Austria (1) · Belgium (1) · Brazil (1) · Bulgaria (1) · Chile (1) · Croatia (1) · Czechia (1)
Ales Rozman, MD (1) · Apichat Tantraworasin (1) · Devanand Anantham, FCCP (1) · Friedemann Schad, MD (1) · Giorgio Stefanutti, MD (1) · Hyo-Chun Yoon, MD (1) · Jamie Penk, MD (1) · Jemi Olak, MD (1) · Jin Li, Doctor (1) · John C. Ruckdeschel, MD (1) · Kook Joo Na, MD (1) · Nan Du (1) · PierGiorgio Gamba, MD (1) · Randolph S. Marks, MD (1)
PMID 15764775, PMID 14973997, PMID 16478853, PMID 17567670, PMID 23418922, PMID 23816016, PMID 24942631, PMID 25172965
U10CA031946 (1), U10CA076001 (1)