28 completed, 13 unknown, 9 terminated, 3 recruiting. 58 Phase 2, 8 Phase 1, 4 Phase 3.
Follow Pleural Effusion: new trials by email Literature Review of Pleural Effusion trials Research Report on Pleural Effusion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural Effusion JMKX000197, Cisplatin - Malignant Pleural Effusions (Mpe) | Phase 2 | Not yet recruiting | Shanghai Jeyou Pharmaceutical Co., Ltd. | 120 | 2026-08-17 | 2026-06-16 |
| Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion Furmonertinib, Thoracic Radiotherapy (TRT) - Lung Cancer (NSCLC), Malignant Pleural Effusions (Mpe)- Pleurodesis | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 63 | 2026-07-01 | 2026-07-17 |
| First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection - Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Gang Hou | 105 | 2026-04-24 | 2026-05-15 |
| Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked Effusion Intrapleural Hydrogen Peroxide (H_2O_2), Intrapleural Corticosteroids, Thoracoscopic Mechanical Pleurolysis - Pleural Infection, Pleural Adhesions | Phase 2 | Completed | Delta University for Science and Technology | 36 | 2026-03-26 | 2026-07-20 |
| Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +] Pleural Saline Irrigation - Pleural Effusion Associated With Pulmonary Infection, Pleural Effusion Disorder | Phase 2 | Recruiting | Beth Israel Deaconess Medical Center | 96 | 2025-04-10 | 2026-08-28 |
| A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLC M701 pleural infusion, Pleural drainage, Cisplatin pleural infusion - Malignant Pleural Effusions, NSCLC Stage IV | Phase 1 / Phase 2 | Recruiting | Wuhan YZY Biopharma Co., Ltd. | 116 | 2022-09-30 | 2026-07-08 |
| A Study of Intrapleural Administration of Bevacizumab and Camrelizumab for Malignant Pleural Effusion bevacizumab and camrelizumab - Malignant Pleural Effusion | Phase 1 / Phase 2 | Unknown | The First Affiliated Hospital of Zhengzhou University | 55 | 2022-08-01 | 2022-04-15 |
| Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma RSO-021 - Malignant Pleural Effusion, Malignant Pleural Mesothelioma | Phase 1 / Phase 2 | Completed | RS Oncology LLC | 50 | 2022-03-31 | 2026-07-24 |
| A Study to Evaluate LTI-01 in Patients With Infected, Non-draining Pleural Effusions LTI-01, Placebo - Pleural Effusion | Phase 2 | Completed | Rein Therapeutics | 44 | 2020-09-26 | 2023-03-30 |
| Intrapleural Instillation of the Nivolumab in Cancer Patients With Pleural Effusion. Nivolumab - Renal Cell Cancer Metastatic, Non-small Cell Lung Cancer Metastatic | Phase 2 | Completed | Kidney Cancer Research Bureau | 26 | 2020-08-10 | 2023-03-08 |
| A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion Talimogene laherparepvec (TVEC), Nivolumab - Malignant Pleural Effusion, Stage IV Metastatic Cancer | Phase 1 / Phase 2 | Terminated | UNC Lineberger Comprehensive Cancer Center | 1 | 2019-03-06 | 2021-04-20 |
| A Study of Syngenon (BSG-001) for Inhalation in Subjects With Malignant Pleural Effusion and/or Malignant Ascites BSG-001 - Malignant Pleural Effusion, Malignant Ascites | Phase 1 / Phase 2 | Unknown | BioSyngen Pte Ltd | 58 | 2019-01-01 | 2018-11-08 |
| Management of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis Silver Nitrate, Indwelling Pleural Catheter - Pleural Effusion, Malignant | Phase 1 / Phase 2 | Unknown | Assiut University | 50 | 2019-01-01 | 2018-12-20 |
| The Safety and Efficacy of Fibrinolysis in Patients With an Indwelling Pleural Catheter for Multi-loculated Malignant Pleural Effusion. tPA standard dosage, tPA low dosage - Pleural Effusion, Cancer, Lung | Phase 2 | Withdrawn | Yale University | 2018-12-01 | 2020-03-05 | |
| A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC Radiation, Chemotherapy - Malignant Pleural Effusion, Nonsmall Cell Lung Cancer, Stage IV | Phase 2 | Unknown | Guizhou Medical University | 68 | 2018-09-01 | 2019-06-14 |
| Persistent Pleural Effusion Treatment Following Cardiothoracic Surgery by Platelet-Fibrin Glue Platelet-Rich Plasma and Fibrin Glue - Pleural Effusion | Phase 2 | Completed | Daryoush Hamidi Alamdari, PhD | 19 | 2017-05-01 | 2024-06-07 |
| Use of Vasopressin Following the Fontan Operation Vasopressin, Normal Saline - Pleural Effusion, Single-ventricle | Phase 2 / Phase 3 | Completed | Wake Forest University Health Sciences | 12 | 2016-12-01 | 2024-10-24 |
| Bevacizumab in the Treatment of Malignant Pleural Effusions of Non-squamous Non-small Cell Lung Cancer Bevacizumab - Malignant Pleural Effusion | Phase 2 | Unknown | Peking University Cancer Hospital & Institute | 87 | 2016-10-01 | 2018-11-07 |
| Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer intrapleural docetaxel administration - Pleural Effusion, Malignant, Non-small Cell Carcinoma | Phase 2 | Completed | Asan Medical Center | 4 | 2016-07-26 | 2019-03-08 |
| Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion tumor derived microparticles, cisplatin - Malignant Pleural Effusion | Phase 2 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 90 | 2016-01-01 | 2019-02-26 |
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Pleural Effusion, Malignant (42) · Carcinoma, Non-Small-Cell Lung (18) · Lung Neoplasms (12) · Neoplasm Metastasis (7) · Adenocarcinoma of Lung (4) · Carcinoma, Ovarian Epithelial (3) · Fallopian Tube Neoplasms (3) · Ascites (2) · Empyema (2) · Empyema, Pleural (2) · Myeloproliferative Disorder, Chronic, with Eosinophilia (2) · Ovarian Neoplasms (2) · Pericardial Effusion (2) · Small Cell Lung Carcinoma (2)
Respiratory Tract Diseases (58) · Pleural Diseases (57) · Neoplasms (48) · Neoplasms by Site (47) · Respiratory Tract Neoplasms (47) · Thoracic Neoplasms (47) · Pleural Neoplasms (42) · Lung Diseases (25) · Bronchial Neoplasms (20) · Carcinoma, Bronchogenic (20) · Lung Neoplasms (14) · Pathological Conditions, Signs and Symptoms (13) · Pathologic Processes (12) · Neoplasms by Histologic Type (9)
Cisplatin (8) · Carboplatin (6) · Bevacizumab (5) · Paclitaxel (5) · Docetaxel (4) · Drug Therapy (3) · Gemcitabine (3) · Saline Solution (3) · Taxes (3) · Cetuximab (2) · Fluorodeoxyglucose F18 (2) · Nivolumab (2) · Pemetrexed (2) · Silver Nitrate (2) · vandetanib (2)
M.D. Anderson Cancer Center (3) · National Cancer Institute (NCI) (3) · Genzyme, a Sanofi Company (2) · H. Lee Moffitt Cancer Center and Research Institute (2) · University of Washington (2) · Abramson Cancer Center at Penn Medicine (1) · Asan Medical Center (1) · Assiut University (1) · Azienda Ospedaliera di Padova (1) · Beth Israel Deaconess Medical Center (1) · BioSyngen Pte Ltd (1) · CanBas Co. Ltd. (1) · Canadian Cancer Trials Group (1) · Cancer Trials Ireland (1) · Daryoush Hamidi Alamdari, PhD (1)
United States (24) · China (11) · Canada (3) · Italy (3) · United Kingdom (3) · Spain (2) · Australia (1) · Brazil (1) · Egypt (1) · Germany (1) · Iran (1) · Ireland (1) · Netherlands (1) · Russia (1) · Slovenia (1)
Adnan Majid, MD (1) · Alberto Chiappori, MD (1) · Ales Rozman, MD (1) · Bo Huang, Ph.D (1) · Carlos A. Jimenez, MD (1) · Carlos Jimenez, M.D. (1) · Chao H Huang, MD, FACP (1) · Daryoush Hamidi-Alamdari, Ph.D (1) · Diane M. Provencher, MD, FRCS, FACOG (1) · Feng Wang (1) · Gang Hou, PhD (1)
PMID 16107633, PMID 16111068, PMID 16790519, PMID 16797681, PMID 16940982, PMID 18300255, PMID 18561992, PMID 18710781, PMID 21267391, PMID 22083202, PMID 23178954, PMID 23601750, PMID 23925664, PMID 24913066, PMID 25798278, PMID 26793618, PMID 27007334, PMID 28363363, PMID 29186319, PMID 35080187, PMID 42310706, PMID 42448681
U10CA031946 (2), 2009 (1), R21CA123866 (1), U10CA025224 (1), U10CA180821 (1)