3 completed, 2 unknown, 1 terminated, 1 withdrawn. 6 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 2, Unknown 2, Terminated 1, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
Follow THK5351: new trials by email Literature Review of THK5351 trials Research Report on THK5351
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Influence of [18F]PMPBB3 and [18F]THK5351 PET Distribution Patterns on Post-stroke Cognitive Impairment PMPBB3, THK5351 - Post-stroke Cognitive Impairment, Neuroinflammation | Phase 2 | Unknown | Chang Gung Memorial Hospital | 80 | 2020-11-01 | 2023-05-01 |
| TAU PET Imaging in Northern Manhattan Study of Metabolism and Mind 18F-THK-5351 - Diabetes Mellitus, Alzheimer Dementia | Phase 2 | Withdrawn | Columbia University | 2017-12-01 | 2017-12-29 | |
| The Influence of Sequential Tau Protein and Amyloid Plaque Imaging Changes on Stroke Prognosis and Cognitive Outcome [18F]THK-5351, [18F]AV-45 - Post-stroke Dementia, Vascular Mild Cognitive Impairment | Phase 2 | Unknown | Chang Gung Memorial Hospital | 200 | 2017-06-01 | 2023-05-06 |
| A Phase I [18F]THK-5351 Positron Emission Tomography Study in Healthy Subjects and Alzheimer's Disease [18F]THK-5351 - Alzheimer Disease | Phase 1 | Completed | Asan Foundation | 12 | 2017-05-17 | 2020-12-14 |
| Imaging Tau in Alzheimer's Disease and Normal Aging 18F-THK-5351, Lumbar Puncture (optional) - Alzheimer's Disease | Phase 2 | Terminated | William Charles Kreisl | 17 | 2016-07-01 | 2018-11-19 |
| [18F]THK-5351 Positron Emission Computed Tomography Study of Normal, Mild Cognitive Impairment, Alzheimer's Disease and Other Neurodegenerative Disease [18F]THK-5351 - Alzheimer's Disease, Mild Cognitive Impairment | Phase 2 | Completed | Jae Seung Kim | 135 | 2016-01-11 | 2020-12-14 |
| The Aging Brain and Cognition: Contribution of Vascular Injury, Amyloid Plaque and Tau Protein to Cognitive Dysfunction After Stroke THK-5351, AV-45 - Post-stroke Dementia, Vascular Mild Cognitive Impairment | Phase 2 | Completed | Chang Gung Memorial Hospital | 181 | 2016-01-04 | 2023-05-06 |
Alzheimer Disease (4) · Cognitive Dysfunction (2) · Nerve Degeneration (2) · Pick Disease of the Brain (2) · Dementia (1) · Diabetes Mellitus (1) · Frontotemporal Dementia (1) · Inflammation (1) · Neurodegenerative Diseases (1) · Neuroinflammatory Diseases (1)
Chang Gung Memorial Hospital (3) · Asan Foundation (1) · Columbia University (1) · Jae Seung Kim (1) · William Charles Kreisl (1)
Taiwan (3) · South Korea (2) · United States (2)
Huang Kuo-Lun, M.D. (1) · Jae Seung Kim, M.D.,Ph.D. (1) · JaeEun Kim (1) · Jose A Luchsinger, MD (1) · William C Kreisl, MD (1)
K23AG052633 (1), R01AG050440 (1)