73 completed, 44 unknown, 30 recruiting, 21 active not recruiting. 164 Not applicable, 11 Phase 4, 4 Phase 2, 1 Phase 1, 1 Phase 3.
Follow Persistent Atrial Fibrillation: new trials by email Literature Review of Persistent Atrial Fibrillation trials Research Report on Persistent Atrial Fibrillation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lattice vs Pentaspline Comparative Evaluation in Persistent AF Pulmonary vein isolation - Persistent Atrial Fibrillation | Not applicable | Not yet recruiting | Mitera Hospital | 250 | 2027-03-01 | 2026-09-15 |
| A Multicenter Feasibility Study With the VERAFEYE Imaging and Guidance System as Anatomical Navigation System Catheter Ablation - Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | Not applicable | Not yet recruiting | LUMA Vision Ltd. | 50 | 2026-11-01 | 2026-09-17 |
| Pulsed Field Ablation for the Treatment of Persistent Atrial Fibrillation: Pulmonary Vein Plus Superior Vena Cava Isolation Versus Pulmonary Vein Isolation Alone-A Prospective, Multicenter, Randomized Controlled Study Pulsed Field Ablation - pulmonary vein isolation, Pulsed Field Ablation - Pulmonary Vein Isolation + Superior Vena Cava Isolation - Persistent Atrial Fibrillation | Not applicable | Not yet recruiting | Ruijin Hospital | 340 | 2026-10-08 | 2026-09-14 |
| Sevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial Fibrillation Ablation Sevoflurane, propofol - Persistent Atrial Fibrillation | Phase 4 | Not yet recruiting | Hüseyin Ulaş Pinar | 124 | 2026-10-01 | 2026-10-16 |
| Outcomes of an Optimized Workflow With PulseSelect Pulsed Field Ablation (PFA) System in Paroxysmal and Persistent Atrial Fibrillation PulseSelect Pulse Field Ablation (PFA) System - Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation | Not applicable | Not yet recruiting | Medtronic Cardiac Ablation Solutions | 320 | 2026-10-01 | 2026-10-09 |
| Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation FARAFLEX Mapping and Pulsed Field Ablation (PFA) System - Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation | Not applicable | Recruiting | Boston Scientific Corporation | 571 | 2026-07-07 | 2026-09-24 |
| Atrial Remodeling After PFA Substrate Modification for Persistent AF (PeAF) Pulsed-Field Ablation with FARAWAVE Catheter System - Persistent Atrial Fibrillation, Atrial Fibrillation (AF) | Not applicable | Enrolling by invitation | Taipei Veterans General Hospital, Taiwan | 30 | 2026-07-01 | 2026-10-09 |
| Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial Fibrillation Tirzepatide, Standard Care (in control arm) - Atrial Fibrillation Ablation, Persistent Atrial Fibrillation | Not applicable | Not yet recruiting | National Taiwan University Hospital | 200 | 2026-06-16 | 2026-06-12 |
| Pulsed Field Ablation Versus Radiofrequency Ablation: Effects of Pulmonary Vein Isolation Combined With Left Atrial Posterior Wall Isolation on Postoperative Gastric Motility in Patients With Persistent Atrial Fibrillation Pulsed Field Ablation, Radiofrequency Ablation - Persistent Atrial Fibrillation | Not yet recruiting | Xijing Hospital | 20 | 2026-05-31 | 2026-06-02 | |
| PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF progressive resistance training, combined aerobic + resistance training - Atrial Fibrillation (AF), Atrial Fibrillation (Paroxysmal) | Not applicable | Recruiting | Northwestern University | 30 | 2026-05-15 | 2026-08-24 |
| Circumferential Pulmonary Venous Isolation Combined With Bachmann Bundle Modification Versus Circumferential Pulmonary Venous Isolation for Persistent Atrial Fibrillation Traditional pulmonary vein isolation (PVI) ablation, Bachmann bundle modification - Persistent Atrial Fibrillation | Not applicable | Not yet recruiting | Shenyang Northern Hospital | 320 | 2026-05-01 | 2026-05-11 |
| A Study on the Therapeutic Value of Additional Left Atrial Posterior Wall Isolation Guided by Voltage Mapping in Persistent Atrial Fibrillation. superior vena cava isolation, Abnormal left atrial substrate - Persistent Atrial Fibrillation | Not applicable | Not yet recruiting | Hangzhou Dinova EP Technology Co., Ltd | 350 | 2026-04-30 | 2026-05-15 |
| Evaluation of the Efficacy of Pulmonary Vein Isolation by Pulsed-field Ablation in Persistent Atrial Fibrillation: a Multicenter Study With Follow-up by Implantable Cardiac Monitor Persistent atrial fibrillation ablation using Pulsed-field ablation - Persistent Atrial Fibrillation | Not applicable | Recruiting | Centre Hospitalier Universitaire de Nice | 60 | 2026-04-13 | 2026-06-11 |
| Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF) Sphere-9 Catheter Ablation - Atrial Fibrillation (AF), Persistent Atrial Fibrillation | Not applicable | Recruiting | Medtronic Cardiac Ablation Solutions | 400 | 2026-04-08 | 2026-10-19 |
| PVI Alone Versus PVI Plus PWI and SVCI With PFA AF Ablation: PVI + PWI + SVCI, PFA, Implantable loop recorder - Persistent Atrial Fibrillation | Not applicable | Recruiting | Edward Gerstenfeld, MD | 220 | 2026-04-03 | 2026-07-14 |
| Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration PVI Ablation, Left Atrial Appendage Occluder Implant - Atrial Fibrillation (AF), Paroxysmal AF | Not applicable | Recruiting | Abbott Medical Devices | 240 | 2026-03-31 | 2026-07-13 |
| REPRESENT-PF Registry FARAWAVE Pulsed Field Ablation Catheter - Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation | Recruiting | Vivek Reddy | 275 | 2026-03-30 | 2026-04-17 | |
| Catheter Ablation of Advanced Forms of Atrial Fibrillation Endovascular ablation set mimicking cox maze 4 procedure. - Persistent Atrial Fibrillation, Persistent Atrial Fibrillation Longstanding | Not applicable | Enrolling by invitation | University Medical Centre Ljubljana | 50 | 2026-03-25 | 2026-04-06 |
| Evaluation of Novel Waveforms Delivered Using the FARAPULSE™ PFA System FARAPULSE™ Pulsed Field Ablation (PFA) System - Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | Not applicable | Recruiting | Boston Scientific Corporation | 200 | 2026-02-12 | 2026-09-24 |
| Study on the Prevention of Atrial Fibrillation Recurrence After Ablation by Qidong Yixin Granule Qi Dong Yi Xin Granules, Placebo - Persistent Atrial Fibrillation | Phase 4 | Recruiting | Sir Run Run Shaw Hospital | 846 | 2026-02-09 | 2026-04-02 |
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Atrial Fibrillation (209) · Arrhythmias, Cardiac (16) · Tachycardia, Ventricular (6) · Heart Diseases (5) · Heart Failure (5) · Cardiovascular Diseases (4) · Recurrence (4) · Ventricular Premature Complexes (4) · Atrial Flutter (3) · Motor Activity (2) · Atrial Remodeling (1) · Cardiac Conduction System Disease (1) · Cardiomyopathies (1) · Cicatrix (1) · Cognitive Dysfunction (1)
Pathologic Processes (209) · Pathological Conditions, Signs and Symptoms (209) · Cardiovascular Diseases (205) · Heart Diseases (204) · Arrhythmias, Cardiac (193) · Cardiac Conduction System Disease (6) · Tachycardia (6) · Cardiac Complexes, Premature (4) · Disease Attributes (4) · Behavior (2) · Vascular Diseases (2) · Body Weight (1) · Cognition Disorders (1) · Death (1) · Fibrosis (1)
Catheter Ablation (24) · Radiofrequency Ablation (11) · Drug Delivery Systems (4) · Amiodarone (2) · Desmoglein 1 (2) · High-Intensity Interval Training (2) · Irreversible Electroporation Therapy (2) · Magnetic Resonance Imaging (2) · Propafenone (2) · Single Person (2) · ibutilide (2) · Anti-Arrhythmia Agents (1) · Blood Specimen Collection (1) · Body Surface Potential Mapping (1) · Botulinum Toxins (1)
Abbott Medical Devices (14) · Boston Scientific Corporation (12) · Shanghai Chest Hospital (11) · Biosense Webster, Inc. (7) · Vivek Reddy (7) · Medtronic Cardiac Ablation Solutions (6) · Royal Brompton & Harefield NHS Foundation Trust (5) · AtriCure, Inc. (4) · Barts & The London NHS Trust (3) · Beijing Anzhen Hospital (3) · China National Center for Cardiovascular Diseases (3) · Korea University Anam Hospital (3) · Meshalkin Research Institute of Pathology of Circulation (3) · Ottawa Heart Institute Research Corporation (3) · The Third People's Hospital of Chengdu (3)
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Vivek Reddy, MD (7) · Andrea Natale, MD (4) · Kristin Ruffner (3) · Arash Aryana, MD (2) · Atul Verma, MD (2) · Biosense Webster, Inc. Clinical Trial (2) · Christopher Piorkowski, MD (2) · Florian Hintringer, MD (2) · Jonathan S Steinberg, MD (2) · Khaldoun Tarakji, MD (2) · Nishaki Mehta, MD (2) · Richard Schilling, FRCP MD (2) · Stephan Willems, MD (2) · Tom Wong, MD (2)
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