112 completed, 27 recruiting, 20 not yet recruiting, 18 unknown. 83 Not applicable, 18 Phase 4, 10 Phase 2, 10 Phase 3, 6 Early Phase 1.
Follow Periodontal Disease: new trials by email Literature Review of Periodontal Disease trials Research Report on Periodontal Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Novel Proline-rich Peptide Hydrogel for Periodontal Regeneration in Adult Periodontitis Patients Hydrogel - Periodontal Disease, Intrabony Periodontal Defects | Phase 1 / Phase 2 | Not yet recruiting | Siddharth Shanbhag | 40 | 2026-11-01 | 2026-05-14 |
| Periodontal Disease and Small Vulnerable Newborns in Rural Nepal: A Community-based Trial A package of oral health interventions, including a daily antiseptic oral rinse (alcohol-free cetylpyridinium chloride (0.075%)) - Preterm Birth, Low Birth Weight | Phase 3 | Not yet recruiting | Johns Hopkins Bloomberg School of Public Health | 2280 | 2026-10-01 | 2026-07-09 |
| Probiotic Response in Periodontal Disease Probiotic Blend Lozenge, Placebo Lozenge - Periodontal Disease | Not applicable | Not yet recruiting | University of New Hampshire | 100 | 2026-10-01 | 2026-07-21 |
| Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients Minimally Invasive Nonsurgical Therapy, Injectable Platelet-Rich Fibrin, Chlorhexidine 2% - Bony Defects, Periodontal Disease | Phase 1 / Phase 2 | Not yet recruiting | Cairo University | 63 | 2026-09-30 | 2026-08-27 |
| CHEER Oral Health in Pregnancy Study Enhanced Care, Enhanced Care + - Gingivitis, Dental Health | Not applicable | Recruiting | University of California, San Francisco | 160 | 2026-09-29 | 2026-10-08 |
| Oral Hygiene Assistance Training Program Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash - Elderly, Periodontal Disease | Phase 4 | Not yet recruiting | Colgate Palmolive | 500 | 2026-09-20 | 2026-09-08 |
| Laser Assisted Open Flap Debridement Mechanical Open Flap debridement, Laser assisted open flap debridement - Periodontal Disease, Periodontal Bone Loss | Not applicable | Not yet recruiting | University of Bari Aldo Moro | 20 | 2026-09-10 | 2026-09-10 |
| Periodontal Status and Thyroid Markers in Pregnancy Pregnancy, Thyroid Disease Pregnancy | Not yet recruiting | Postgraduate Institute of Dental Sciences Rohtak | 100 | 2026-09-03 | 2026-08-26 | |
| Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment Active Oral Hygiene Regimen, Placebo Oral Hygiene Regimen - Periodontal Disease, Gingival Inflammation and Bleeding | Phase 3 | Not yet recruiting | Colgate Palmolive | 100 | 2026-09-01 | 2026-09-03 |
| Effect of GLP-1 Receptor Agonists on Periodontal Health and Response to Nonsurgical Periodontal Therapy non-surgical periodontal therapy - Periodontal Disease, Obesity & Overweight | Not applicable | Not yet recruiting | Cukurova University | 40 | 2026-09-01 | 2026-08-20 |
| Integrated Diabetes and Oral Health Care in Oman Health Belief Model-Based Integrated Diabetes-Oral Health Educational Intervention, Standard Diabetes Education and Routine Care - Type 2 Diabetes Mellitus, Periodontitis | Not applicable | Not yet recruiting | Oman Ministry of Health | 290 | 2026-09-01 | 2026-09-09 |
| Discovery and Validation of Biomarkers for Periodontitis, Dental Caries and Oral Squamous Cell Carcinoma Step 1 and 2 periodontal therapy according to the EFP clinical practice guidelines, Dental filling with or without root canal treatment, Oral cancer surgical resection including extension, dissection and reconstruction with adjunctive radiation, chemotherapy and/or biological treatments per international guidelines, - Oral Squamous Cell Carcinoma (OSCC), Periodontal Disease | Not yet recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 4000 | 2026-08-25 | 2026-08-04 | |
| Maternal Periodontal Inflammation and Pregnancy Outcomes: Salivary and Amniotic Biomarkers Periodontal Disease, Pregnancy | Not yet recruiting | Saglik Bilimleri Universitesi | 80 | 2026-08-20 | 2026-07-29 | |
| Dental Loupe Versus Dental Operating Microscope for Non-Surgical Periodontal Treatment Mechanical debridement and dental plaque sample collection with dental loupe, Mechanical debridement and dental plaque sample collection with dental microscope - Periodontitis, Periodontitis and Treatment Need | Not applicable | Recruiting | Saglik Bilimleri Universitesi | 30 | 2026-08-01 | 2026-09-21 |
| Evaluation of NIPSA Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in theTreatment of Intrabony Defects allopastic bone graft, cross-linked hyaluronic acid, Non-Incised Papillae Surgical Approach - Intrabony Periodontal Defect, Periodontal Disease | Phase 1 / Phase 2 | Not yet recruiting | Mansoura University | 60 | 2026-08-01 | 2026-08-04 |
| Photodynamic Therapy as an Adjunct in Periodontal Treatment Scaling and Root Planing, Antimicrobial Photodynamic Therapy - Periodontitis, Periodontal Disease | Not applicable | Enrolling by invitation | Universidad Catolica Santiago de Guayaquil | 30 | 2026-07-28 | 2026-09-25 |
| Serum Inflammatory Protein Concentration During Dental Treatment Blood samples for inflammatory markers, periodontal surgery, Periodontal maintenance - Periodontal Disease, Periodontal Surgery | Recruiting | Ohio State University | 30 | 2026-07-13 | 2026-09-11 | |
| Association Between Periodontal Disease and Chronic Neck Pain Periodontal Disease, Chronic Neck Pain | Recruiting | Nigde Omer Halisdemir University | 123 | 2026-07-11 | 2026-07-17 | |
| Effects of Adjunctive Synbiotic Supplementation to Non-Surgical Periodontal Therapy in Smokers With Periodontitis Synbiotic supplementation, Placebo Administration - Periodontal Disease | Not applicable | Not yet recruiting | Biruni University | 92 | 2026-07-06 | 2026-06-26 |
| Longitudinal Evaluation of Several Modalities of Treatment of Peri-implantitis: 5 to 23 Years Follow-up Periodontal Disease, Microbiology | Not yet recruiting | University of Guarulhos | 300 | 2026-06-29 | 2026-07-07 |
Showing 20 of 198. Sign in to see all of them.
Periodontal Diseases (198) · Periodontitis (60) · Gingivitis (23) · Diabetes Mellitus, Type 2 (15) · Dental Caries (11) · Diabetes Mellitus (11) · Dental Plaque (10) · Smoking (8) · Inflammation (7) · Cardiovascular Diseases (6) · Obesity (6) · Periodontal Pocket (6) · Alveolar Bone Loss (5) · Gingival Diseases (5) · Chronic Periodontitis (4)
Stomatognathic Diseases (198) · Mouth Diseases (197) · Nutritional and Metabolic Diseases (36) · Pathological Conditions, Signs and Symptoms (34) · Metabolic Diseases (30) · Glucose Metabolism Disorders (25) · Infections (24) · Endocrine System Diseases (23) · Pathologic Processes (22) · Gingival Diseases (21) · Tooth Diseases (20) · Musculoskeletal Diseases (14) · Diabetes Mellitus (12) · Signs and Symptoms (12) · Female Urogenital Diseases and Pregnancy Complications (11)
Tooth Exfoliation (17) · Root Planing (14) · Blood Specimen Collection (5) · Doxycycline (4) · Periodontal Index (4) · Chlorhexidine (3) · Control Groups (3) · Metronidazole (3) · Surveys and Questionnaires (3) · Aspirin (2) · Cetylpyridinium (2) · Dental Scaling (2) · Ethanol (2) · Lasers, Semiconductor (2) · Minocycline (2)
University of Sao Paulo (6) · Cairo University (5) · Colgate Palmolive (5) · Mansoura University (4) · University of Michigan (4) · National Institute of Dental and Craniofacial Research (NIDCR) (3) · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (3) · University of Campinas, Brazil (3) · University of Guarulhos (3) · University of Roma La Sapienza (3) · Uskudar University (3) · Abant Izzet Baysal University (2) · Al-Azhar University (2) · Ankara University (2) · Escola Bahiana de Medicina e Saude Publica (2)
United States (40) · Turkey (Türkiye) (30) · Brazil (18) · Egypt (12) · Italy (10) · France (5) · United Kingdom (5) · Canada (4) · Chile (4) · China (4) · India (4) · Spain (4) · Israel (3) · Poland (3) · Germany (2)
Andrea Scribante, Associate Professor (2) · Enilson A Sallum, PhD (2) · Niki M Moutsopoulos, D.D.S. (2) · Adriana P Sant'Ana, DDS PhD (1) · Ahmed Hashem Alshareef, Bachelors degree (1) · Ali Abou Sulaiman, Ph.D. in Periodontology (1) · Amit Acharya, BDS, MS, PhD (1) · Amr M. Elkhouli, ph.D (1) · Andreas G Anwandter, DDS (1) · Anh TV Nguyen, Assoc. Prof. (1) · Anna C Horliana, PhD (1) · Antonio Quintero, DDS (1) · Arie Jan van Winkelhoff, prof. dr. (1) · Ashok Kumar, MD (1)
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K23DE019872 (1), K23DE021779 (1), P20RR017696 (1), R01DE012215 (1), R01DE013796 (1), R01DE015345 (1), R01DE021052 (1), R01HD119055 (1), RC2AR058986 (1), U01DE021127 (1), U54GM104944 (1), UL1RR024148 (1)