18 recruiting, 14 completed, 11 not yet recruiting, 4 active not recruiting. 35 Not applicable, 5 Phase 2, 3 Phase 3, 3 Phase 4, 1 Phase 1.
Follow Perimenopause: new trials by email Literature Review of Perimenopause trials Research Report on Perimenopause
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Structured Health Information-Seeking Training on Cyberchondria and E-Health Literacy in Menopausal Women: A Randomized Controlled Trial Video-Based Health Information-Seeking Education, Pecha Kucha-Based Health Information-Seeking Education - Perimenopause, Postmenopause | Not applicable | Not yet recruiting | Istanbul University | 60 | 2027-01-24 | 2026-09-22 |
| No Time to Pause: Physical Activity to Improve Health of Midlife Hispanic Women Physical activity intervention - Elevated Blood Pressure, Perimenopause | Not applicable | Not yet recruiting | The University of Texas Medical Branch, Galveston | 40 | 2027-01-20 | 2025-12-08 |
| Evaluation of the Effects of Lifestyle Medicine and Mindfulness-based Group Medical Visits on Stress, Microbiome, and Quality of Life in Women Experiencing Perimenopause and Menopause Navigating Menopause with a Mindfulness-Based Group Medical Visit - Perimenopause, Menopause | Not applicable | Not yet recruiting | Ohio State University | 40 | 2027-01-01 | 2026-10-16 |
| Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition Transdermal estradiol, Standard of care - non hormonal - Menopause, Perimenopause | Phase 4 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 100 | 2026-11-01 | 2026-07-29 |
| Effects of a Dietary Supplement in Women With Late Perimenopause or Early Postmenopause Plant Extract-Based Dietary Supplement, Placebo - Perimenopause, Postmenopause | Not applicable | Recruiting | University of Alicante | 120 | 2026-11-01 | 2026-10-13 |
| Transcutaneous Auricular Neurostimulation (tAN) for Premenstrual Dysphoric Disorder (PMDD) and Perimenopause transcutaneous auricular neurostimulation (tAN) - Perimenopause, PMDD | Not applicable | Enrolling by invitation | Texas Christian University | 20 | 2026-10-22 | 2026-10-23 |
| Effect of Lifestyle Intervention on Menopausal Symptoms, Sleep Quality, and Anxiety in Peri- and Postmenopausal Women Structured Lifestyle Education, Standard Care (in control arm) - Perimenopause, Postmenopause | Not applicable | Recruiting | Konya Beyhekim Training and Research Hospital | 100 | 2026-10-15 | 2026-10-16 |
| Hop Extract Versus Soy Isoflavone Extract for Menopausal Symptoms (HOPES) Full Spectrum hop extract (MENODUO FullSpectrum), Soy isoflavone extract - Menopause, Perimenopause | Not applicable | Not yet recruiting | Menoclinica by Palacios | 120 | 2026-10-01 | 2026-10-29 |
| Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIV Vaginal estradiol tablets, Vaginal moisturizer - Menopausal Complaints, Vaginal Atrophy | Phase 4 | Not yet recruiting | Albert Einstein College of Medicine | 62 | 2026-09-01 | 2026-07-28 |
| Cuidar-ME, a Web-based Psychological Intervention for (Peri)Menopausal Women: A Pilot Randomized Controlled Trial Cuidar-ME - Menopause, Perimenopause | Not applicable | Active not recruiting | University of Coimbra | 150 | 2026-09-01 | 2026-10-01 |
| Amygdala Insula Retraining in the Management of Perimenopause Symptoms Amygdala and Insula Retraining (AIR) - Perimenopause, Menopausal Complaints | Not applicable | Recruiting | Chronic Conditions Research Fund | 160 | 2026-07-15 | 2026-06-29 |
| CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life Lutea Transcranial Direct Current Stimulation (tDCS) Device, Samphire Guided Care Program - Premenstrual Syndrome, Premenstrual Dysphoric Disorder | Recruiting | Samphire Group, Inc. | 50 | 2026-06-01 | 2026-07-01 | |
| Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY) Perimenopause, Perimenopause-Related Depression | Enrolling by invitation | Healing Hope International | 12 | 2026-06-01 | 2026-04-06 | |
| Occupational Disruption and Role Strain During Perimenopause Confidential Surveys - Perimenopause | Not yet recruiting | Russell Sage College | 100 | 2026-06-01 | 2026-05-06 | |
| Cognitive Task Sensitivity in Perimenopause and Nutritional Status Perimenopause, Cognitive Function in Perimenopause | Not yet recruiting | Northumbria University | 60 | 2026-06-01 | 2026-06-15 | |
| Our Transitions: Improving the Path to Menopause With Personal Digital Health Technologies Perimenopause, Menopause | Not yet recruiting | 4YouandMe | 1250 | 2026-05-01 | 2026-05-20 | |
| Impact of a Novel Functional Snack on Perimenopausal Symptoms and Well-being Functional Snacks, Placebo Snacks - Perimenopause, Perimenopause-Related Depression | Not applicable | Recruiting | King's College London | 20 | 2026-04-24 | 2026-05-20 |
| 12-week Multi-vitamin/Mineral Supplementation on Peri-menopause Symptoms, Cognition, Sleep, and Psychological Well-being. Placebo, Multivitamin/mineral supplement - Perimenopause, Perimenopausal Women | Not applicable | Active not recruiting | Northumbria University | 58 | 2026-04-07 | 2026-08-05 |
| Exercise in Perimenopause to Improve Cognitive Health Progressive Resistance Training, Balance, Flexibility, and Tone Exercises - Perimenopause, Subjective Cognitive Complaints | Not applicable | Recruiting | University of British Columbia | 50 | 2026-03-30 | 2026-10-20 |
| CARAMEL Observational Study Perimenopause, Menopause | Recruiting | Biogipuzkoa Health Research Institute | 3000 | 2026-03-16 | 2026-07-10 |
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Anxiety Disorders (6) · Hot Flashes (5) · Depression (4) · Mental Fatigue (4) · Motor Activity (4) · Dysmenorrhea (2) · Hypertension (2) · Intermittent Fasting (2) · Pain (2) · Premenstrual Dysphoric Disorder (2) · Primary Ovarian Insufficiency (2) · Psychological Well-Being (2) · Sleep Initiation and Maintenance Disorders (2) · Acquired Immunodeficiency Syndrome (1) · Aging, Premature (1)
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Estradiol (4) · Dietary Supplements (2) · Progesterone (2) · Acupuncture Therapy (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Cognitive Behavioral Therapy (1) · Contraceptives, Oral (1) · Creatine (1) · Diet (1) · Diet, Mediterranean (1) · Escitalopram (1) · Exercise (1) · Gabapentin (1) · Gels (1) · Geritol (1)
Northumbria University (3) · University of British Columbia (2) · University of North Carolina, Chapel Hill (2) · Washington State University (2) · 4YouandMe (1) · AGUNCO Obstetrics and Gynecology Centre (1) · Able Biolabs, LLC (1) · Albert Einstein College of Medicine (1) · American University of Beirut Medical Center (1) · Biogipuzkoa Health Research Institute (1) · Chang Gung Memorial Hospital (1) · Chengdu University of Traditional Chinese Medicine (1) · Chronic Conditions Research Fund (1) · Dr. Nazanin Alavi (1) · Guangdong Provincial Hospital of Traditional Chinese Medicine (1)
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Abbi Lane, PhD (1) · Abbie Smith-Ryan, PhD (1) · Ana Rodriguez-Mateos, PhD (1) · Christine Mulligan (1) · David Crowley, MD (1) · Dr. Jonatha Leicher, MD: Regenerative Medicine (1) · Elena Philippou, PhD (1) · Elizabeth Lorenzo, PhD, RN (1) · Fiona Dodd (1) · Janine A Clayton, M.D. (1) · Jerilynn C Prior, MD, FRCPC (1) · Kerry J Murphy, MD (1) · Marlene Freeman, MD (1)
PMID 12914663, PMID 24886348, PMID 26425364, PMID 29322164, PMID 30003102, PMID 31155270, PMID 31473867, PMID 31838497, PMID 32706883, PMID 33095879, PMID 33288437, PMID 34816248, PMID 35382992, PMID 39138739, PMID 40013047, PMID 40384525, PMID 40854087
2023 (1), R01AG102277 (1), R01HL146558 (1), R01MH087619 (1)