56 completed, 55 unknown, 22 recruiting, 17 not yet recruiting. 49 Not applicable, 36 Phase 2, 35 Phase 1, 10 Phase 3, 10 Phase 4.
Follow Primary Ovarian Insufficiency: new trials by email Literature Review of Primary Ovarian Insufficiency trials Research Report on Primary Ovarian Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral GDC-0077 in Premature Ovarian Insufficiency GDC-0077 - Primary Ovarian Insufficiency | Phase 1 | Not yet recruiting | Women's Hospital School Of Medicine Zhejiang University | 12 | 2026-10-30 | 2026-10-29 |
| Effect and Mechanism of Jiajian Guishen Optimized Formula on Premature Ovarian Insufficiency: Insights Into m6A Modification and Oxidative Stress JJGS - Premature Ovarian Insufficiency | Early Phase 1 | Not yet recruiting | Shi Yun | 45 | 2026-09-30 | 2026-09-25 |
| Finerenone for Premature Ovarian Insufficiency (POI) Finerenone, Placebo - Premature Ovarian Insufficiency | Phase 2 | Not yet recruiting | The University of Hong Kong-Shenzhen Hospital | 46 | 2026-09-15 | 2026-09-11 |
| Pre-pubertal Low Dose Transdermal Estradiol in Turner Syndrome Estradiol transdermal patch 0.025mg/24 hours- 1/8th fractionated patch - Turner Syndrome, Primary Ovarian Insufficiency | Phase 2 | Not yet recruiting | Children's National Research Institute | 15 | 2026-09-01 | 2026-08-25 |
| Ovarian Tissue Allo-transplantation Ovarian tissue allo-transplantation - Ovarian Failure, Ovarian Insufficiency | Not applicable | Not yet recruiting | University Hospitals Cleveland Medical Center | 10 | 2026-09-01 | 2026-07-23 |
| Phase Ⅰ/Ⅱa Trial Evaluating Intravenous hUC-MSCs Injection for Safety, Tolerability and Efficacy in Patients With POI hUC-MSCs Injection (Phase I), hUC-MSCs Injection (Phase IIa), Placebo - Premature Ovarian Insufficiency | Phase 1 / Phase 2 | Recruiting | Shenzhen Wingor Biotechnology Co., Ltd. | 59 | 2026-08-03 | 2026-08-20 |
| Effects of Estrogen on Heart Health in Women With Primary Ovarian Insufficiency Primary Ovarian Insufficiency, Premature Menopause | Recruiting | Massachusetts General Hospital | 45 | 2026-06-22 | 2026-09-08 | |
| Poi for Mama: a Pilot to Improve Maternal Microbiome and Gestational Diabetes Risk Fermented Poi - Gestational Diabetes Mellitus (GDM), Pregnancy | Not applicable | Recruiting | University of Hawaii | 50 | 2026-06-12 | 2026-07-02 |
| Genetic Variants in Idiopathic Premature Ovarian Insufficiency Premature Ovarian Insufficiency | Not yet recruiting | Abdurrahman Hamdi İnan | 100 | 2026-06-10 | 2026-05-19 | |
| Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY) Perimenopause, Perimenopause-Related Depression | Enrolling by invitation | Healing Hope International | 12 | 2026-06-01 | 2026-04-06 | |
| A Retrospective and Prospective Clinical Registry for Data Collection of Perimenopausal, Menopausal and Premature Ovarian Insufficiency Women Menopause, Menopausal Hormone Therapy | Not yet recruiting | IRCCS San Raffaele | 5000 | 2026-06-01 | 2026-05-26 | |
| Umbilical Cord Mesenchymal Stem Cells (UC-MSC) in the Treatment of Primary Ovarian Insufficiency HS_SW01 cells injection - Primary Ovarian Insufficiency (Poi) | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Huishan Biotechnology Co., Ltd. | 21 | 2026-04-15 | 2026-04-27 |
| Evaluating Ovarian Toxicity Outcomes Following Immunotherapy in Patients With Triple-Negative Breast Cancer (TNBC) Triple Negative Breast Cancer (TNBC) | Not yet recruiting | Peter MacCallum Cancer Centre, Australia | 75 | 2026-04-08 | 2026-04-14 | |
| A Clinical Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Premature Ovarian Insufficiency YT023, Control Arm (Conventional Therapy) - Premature Ovarian Insufficiency | Phase 1 / Phase 2 | Active not recruiting | International Peace Maternity and Child Health Hospital | 60 | 2026-03-20 | 2026-04-03 |
| Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI) Primary Ovarian Insufficiency, Azoospermia | Recruiting | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 500 | 2026-03-11 | 2026-03-16 | |
| Improving Outcomes in Early Menopause After Cancer Nurse Navigator Intervention, Education Control - Early Menopause, Cancer | Not applicable | Recruiting | Duke University | 117 | 2026-01-20 | 2026-05-14 |
| A RCT Study on Autologous PRP Injection in Patients With POR PRP injection - Poor Ovarian Response, PRP Injection | Not applicable | Not yet recruiting | Peking University Third Hospital | 142 | 2025-12-15 | 2025-12-15 |
| A RCT Study on Autologous Cell Injection Into the Ovaries of Patients With POR PRP injection, SVF injection - Poor Ovarian Response | Not applicable | Not yet recruiting | Peking University Third Hospital | 198 | 2025-12-15 | 2025-12-15 |
| Gynecological Impact of Allogeneic Hematopoietic Stem Cell Transplantation in Adults Questionnaire - Acute Leukemia | Not applicable | Completed | University Hospital, Bordeaux | 51 | 2025-09-19 | 2026-06-25 |
| Efficacy and Safety of Huanjingjian Decoction in Women With Premature Ovarian Insufficiency Huanjingjian decoction, Hormone replacement therapy, Placebo - Premature Ovarian Insufficiency | Not applicable | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 276 | 2025-09-01 | 2025-09-08 |
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Infertility (22) · Menopause, Premature (17) · Infertility, Female (10) · Turner Syndrome (10) · Polycystic Ovary Syndrome (6) · Hypogonadism (5) · Amenorrhea (4) · Breast Neoplasms (3) · Cardiovascular Diseases (3) · Cognitive Dysfunction (3) · Endometriosis (3) · Osteoporosis (3) · Autoimmune Diseases (2) · Azoospermia (2)
Adnexal Diseases (180) · Female Urogenital Diseases (180) · Female Urogenital Diseases and Pregnancy Complications (180) · Genital Diseases (180) · Genital Diseases, Female (180) · Urogenital Diseases (180) · Endocrine System Diseases (179) · Gonadal Disorders (179) · Ovarian Diseases (179) · Pathological Conditions, Signs and Symptoms (15) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (14) · Genetic Diseases, Inborn (14) · Male Urogenital Diseases (14) · Heart Diseases (13) · Cardiovascular Diseases (12)
Estradiol (7) · Dehydroepiandrosterone (5) · Progesterone (5) · Surveys and Questionnaires (5) · Injections (4) · Saline Solution (4) · Chorionic Gonadotropin (3) · Hormone Replacement Therapy (3) · Lisdexamfetamine Dimesylate (3) · Stem Cell Transplantation (3) · Blood Specimen Collection (2) · Ethinyl Estradiol (2) · Filgrastim (2) · Follicle Stimulating Hormone (2) · Goserelin (2)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (11) · University of Pennsylvania (7) · Assistance Publique - Hôpitaux de Paris (6) · Cengiz Gokcek Women's and Children's Hospital (4) · Center for Human Reproduction (4) · Peking University Third Hospital (4) · Shi Yun (4) · Chinese Academy of Sciences (3) · International Peace Maternity and Child Health Hospital (3) · Radboud University Medical Center (3) · University Hospital, Bordeaux (3) · ART Fertility Clinics LLC (2) · Affiliated Hospital of Nantong University (2) · Al-Azhar University (2) · Ankara City Hospital Bilkent (2)
United States (45) · China (40) · Egypt (10) · France (10) · Turkey (Türkiye) (10) · Netherlands (8) · Greece (4) · Italy (4) · Spain (4) · Canada (3) · Germany (3) · United Arab Emirates (3) · Denmark (2) · Iran (2) · Japan (2)
Norbert Gleicher, MD (4) · C. Neill Epperson, MD (3) · Clarisa R Gracia, MD, MSCE (2) · David Barad, MD, MS (2) · Dongmei Lai, M.D. (2) · Hala Gabr, MD (2) · Hala N Hosni, Professor (2) · Hongmei Wang, Doctor (2) · Ke Xu, Master (2) · Laura Melado, PhD (2) · Lawrence M Nelson, M.D. (2) · Mahmoud Edessy, Professor (2) · Medhat Kamel, Msc (2) · Mohammad AM Ahmed, MD (2) · Naoto Ueno, MD, PhD (2)
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R21CA301298 (1)