10 completed, 4 recruiting, 4 terminated, 2 active not recruiting. 22 Phase 1, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 22 | Completed 10, Recruiting 4, Terminated 4, Active not recruiting 2, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 9 | Completed 6, Not yet recruiting 1, Recruiting 1, Unknown 1 |
Follow Pancreatitis, Chronic: new trials by email Literature Review of Pancreatitis, Chronic trials Research Report on Pancreatitis, Chronic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Food Effect of CBT-248 in Healthy Adult Participants CBT-248, CBT-248 Placebo, Fasted - Period 1 - Chronic Pancreatitis | Phase 1 | Recruiting | Cibus Therapeutics, Inc. | 32 | 2026-10-15 | 2026-10-29 |
| Metabolic Impact of Pancreatic Duct Decompression Endoscopic pancreatic duct decompression - Chronic Pancreatitis | Phase 1 | Recruiting | Mayo Clinic | 30 | 2026-09-30 | 2026-10-01 |
| A Surgical Procedure (Total Pancreatectomy) With a Transplant Procedure (Islet Cell Autotransplantation) for the Treatment of Chronic Pancreatitis and Benign Pancreatic Tumors Pancreatectomy, Quality-of-Life Assessment, Treatment Planning - Benign Pancreatic Neoplasm, Chronic Pancreatitis | Phase 1 / Phase 2 | Not yet recruiting | OHSU Knight Cancer Institute | 12 | 2026-07-01 | 2025-11-25 |
| Soy Tomato Juice to Improve Outcomes in Pancreatitis Soy-tomato juice product, Will include a soy-tomato juice product to be consumed during the 4 week intervention phase. A total of about 12 ounces (administered in two small cans) of the juice will be consumed - Recurrent Acute Pancreatitis, Chronic Pancreatitis | Phase 1 / Phase 2 | Recruiting | Ohio State University | 35 | 2026-04-02 | 2026-10-20 |
| Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis Mesenchymal stem cells, Placebo - Chronic Pancreatitis, Chronic Pain | Phase 1 | Recruiting | VA Office of Research and Development | 40 | 2024-01-01 | 2026-04-07 |
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis Lacosamide - Chronic Pain, Chronic Pain Syndrome | Phase 1 | Active not recruiting | Indiana University | 21 | 2023-03-17 | 2026-06-03 |
| Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT Bone marrow-derived mesenchymal stem cells, Placebo - Chronic Pancreatitis, Mesenchymal Stem Cells | Phase 1 | Active not recruiting | Medical University of South Carolina | 42 | 2021-12-01 | 2026-09-09 |
| Trial of Indomethacin in Chronic Pancreatitis Indomethacin, Placebo, Endoscopy for Pancreatic Function Testing - Chronic Pancreatitis | Phase 1 / Phase 2 | Completed | Mayo Clinic | 27 | 2020-07-15 | 2024-09-04 |
| Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis Prolastin-C, Placebo - Chronic Pancreatitis | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 48 | 2017-01-11 | 2023-06-29 |
| Treatment of IgG4-Related Disease With Revlimid and Rituximab Rituximab, Lenalidomide - Immunoglobulin G Subclass 4 Related Disease, IgG4-related Disease | Phase 1 | Completed | Mayo Clinic | 6 | 2016-04-01 | 2019-07-08 |
| A Dose Ranging Study Evaluating Efficacy and Safety of NI-03 NI-03, Placebo - Chronic Pancreatitis | Phase 1 / Phase 2 | Completed | Kangen Pharmaceuticals, Inc | 264 | 2016-02-24 | 2022-12-16 |
| Carbon Monoxide-Saturated Medium for Islet Isolation Carbon monoxide-bubbled mediums - Chronic Pancreatitis | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 16 | 2015-01-01 | 2019-01-04 |
| Mesenchymal Stem Cell and Islet Co-transplantation autologous mesenchymal stromal cell - Chronic Pancreatitis, Diabetes | Phase 1 | Completed | Medical University of South Carolina | 3 | 2014-12-01 | 2022-04-04 |
| Pancreatic Perfusion Using Secretin and MRI Secretin - Chronic Pancreatitis | Phase 1 / Phase 2 | Unknown | University of Nottingham | 15 | 2012-06-01 | 2016-02-18 |
| Rituximab in IgG4-RD: A Phase 1-2 Trial Rituximab - Retroperitoneal Fibrosis, Autoimmune Pancreatitis | Phase 1 / Phase 2 | Completed | Massachusetts General Hospital | 30 | 2012-04-01 | 2017-07-02 |
| Secretin Infusion for Pain Due to Chronic Pancreatitis Human Secretin - Chronic Pancreatitis | Phase 1 / Phase 2 | Completed | ChiRhoClin, Inc. | 12 | 2010-12-01 | 2016-03-09 |
| Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers Secretin - Chronic Pancreatitis | Phase 1 | Completed | University of Nottingham | 12 | 2010-09-01 | 2011-10-14 |
| A Study of EUR-1066 in Subjects With Chronic Pancreatitis, Exocrine Pancreatic Insufficiency and Chronic Abdominal Pain EUR-1066-A, Zenpep, EUR-1066-B - Chronic Pancreatitis | Phase 1 | Terminated | Forest Laboratories | 15 | 2010-08-02 | 2020-01-18 |
| Viokase 16, Viokase16 Plus Nexium and Nexium Alone Nexium (esomeprazole magnesium), Placebo to Nexium, Viokase 16 (pancrelipase) + Nexium - Chronic Pancreatitis | Phase 1 | Terminated | University of Florida | 12 | 2009-02-01 | 2013-02-21 |
| A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI) Ensure Plus, Pancrelipase in combination with Ensure Plus - Exocrine Pancreatic Insufficiency, Pancreatitis, Chronic | Phase 1 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 13 | 2008-07-01 | 2011-05-19 |
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Pancreatitis (5) · Autoimmune Pancreatitis (2) · Chronic Pain (2) · Diabetes Mellitus (2) · Exocrine Pancreatic Insufficiency (2) · Retroperitoneal Fibrosis (2) · Abdominal Pain (1) · Bronchiolitis Obliterans Syndrome (1) · Cerebral Palsy (1) · Digestive System Diseases (1) · Fibrosis (1) · Hyperalgesia (1) · Immunoglobulin G4-Related Disease (1) · Inflammation (1)
Chronic Disease (22) · Disease Attributes (22) · Pathologic Processes (22) · Pathological Conditions, Signs and Symptoms (22) · Digestive System Diseases (21) · Pancreatic Diseases (21) · Pancreatitis (17) · Immune System Diseases (3) · Metabolic Diseases (3) · Nervous System Diseases (3) · Neurologic Manifestations (3) · Nutritional and Metabolic Diseases (3) · Signs and Symptoms (3) · Autoimmune Diseases (2) · Endocrine System Diseases (2)
Secretin (5) · Pancrelipase (3) · Rituximab (2) · Endoscopy (1) · Ensure Plus (1) · Esomeprazole (1) · Indomethacin (1) · Lacosamide (1) · Lenalidomide (1) · Pancreatectomy (1) · Sodium Chloride (1)
Medical University of South Carolina (4) · Massachusetts General Hospital (3) · Mayo Clinic (3) · University of Nottingham (2) · ChiRhoClin, Inc. (1) · Cibus Therapeutics, Inc. (1) · Forest Laboratories (1) · Indiana University (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · Kangen Pharmaceuticals, Inc (1) · OHSU Knight Cancer Institute (1) · Ohio State University (1) · University of Florida (1) · VA Office of Research and Development (1)
United States (17) · United Kingdom (2) · Australia (1) · Russia (1) · Ukraine (1)
Hongjun Wang, Ph.D (3) · Dushyant V Sahani (2) · Arezou Khosroshahi, MD (1) · Aynur Unalp-Arida, MD, PhD (1) · Brett C Sheppard (1) · Charlton Strange, M.D (1) · Hongjun N Wang, PhD (1) · Hongjun Wang (1) · Honit Piplani (1) · John H Stone, MD, MPH (1) · John Simpson (1) · John Simpson, PhD FRCS (1) · Mark D Topazian, MD (1) · Phiip Hart, MD (1)
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I01CX002516 (1), R01DK105183 (1), R01DK126454 (1), R01DK132709 (1), R01DK138871 (1), R21DK099696 (1), R21DK117212 (1)