15 completed, 6 terminated, 4 withdrawn, 3 unknown. 9 Phase 3, 8 Phase 1, 8 Phase 2, 6 Not applicable, 3 Phase 4.
Follow Secretin: new trials by email Literature Review of Secretin trials Research Report on Secretin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy Subjects Secretin (human synthetic) - ChiRhoClin - Exocrine Pancreatic Insufficiency, Chronic Pancreatitis | Phase 4 | Active not recruiting | Mayo Clinic | 24 | 2026-03-11 | 2026-10-26 |
| Aspiration of Duodenopancreatic Juice After Secretin Stimulation vs Endoscopic Aspiration for Molecular Analysis of Intraductal Papillary Mucinous Intraductal Neoplasia. Secretin, Endoscopic aspiration, Endoscopic ultrasound-guided fine needle aspiration - Intraductal Papillary Mucinous Neoplasm of Pancreas | Phase 3 | Unknown | Fundacion Clinic per a la Recerca Biomédica | 140 | 2023-09-13 | 2023-09-18 |
| Imaging Biomarkers of Pancreatic Function and Disease Research MRI without administration of intravenous secretin, Research MRI with administration of intravenous secretin, Genetic Sequencing - Pancreatitis, Diabetes Mellitus | Phase 4 | Enrolling by invitation | Children's Hospital Medical Center, Cincinnati | 195 | 2023-01-18 | 2026-03-18 |
| Recurrent Abdominal Pain and Exocrine Pancreatic Insufficiency synthetic human secretin - Abdominal Pain, Irritable Bowel Syndrome | Phase 3 | Terminated | Orlando Health, Inc. | 27 | 2022-01-28 | 2024-04-03 |
| The Role of Secretin on the Energy Homeostasis Secretin, Placebo - Obesity, Metabolic Disease | Not applicable | Completed | Steno Diabetes Center Copenhagen | 25 | 2020-03-01 | 2020-11-05 |
| Effect of Secretin in Functional Dyspepsia and Healthy Subjects Human Secretin, Placebo - Dyspepsia, Healthy | Phase 1 / Phase 2 | Completed | Mayo Clinic | 20 | 2018-11-07 | 2020-06-11 |
| Secretin for Acute Pancreatitis Secretin - Pancreatitis, Acute | Phase 2 | Unknown | ChiRhoClin, Inc. | 40 | 2018-10-01 | 2019-04-10 |
| Optical and Biochemical Biomarkers in Early Pancreatic Cancer Synthetic Human Secretin - Pancreatic Cancer | Completed | Mayo Clinic | 346 | 2018-01-11 | 2023-06-06 | |
| MRCP: A Reliable, Non Invasive Method for Staging Chronic Pancreatitis in Pediatrics Secretin - Healthy Volunteers | Not applicable | Completed | Children's Hospital Medical Center, Cincinnati | 57 | 2016-08-10 | 2020-08-07 |
| Secretin Activates Human Brown Fat and Induces Satiation. Secretin Human, Saline Solution, Cold exposure - Obesity | Phase 2 / Phase 3 | Completed | Turku University Hospital | 23 | 2016-08-02 | 2019-12-23 |
| Secretin Infusion to Prevent Pancreatic Leaks Following Pancreatic Resection Secretin, Placebo - Injury of Body of Pancreas | Phase 2 / Phase 3 | Completed | Dartmouth-Hitchcock Medical Center | 170 | 2014-05-01 | 2020-03-31 |
| The Cancer of the Pancreas Screening-5 CAPS5)Study Secretin, MRI, Tumor marker gene test with CA19-9 - Pancreas Cancer, Peutz-Jeghers Syndrome (PJS) | Phase 3 | Recruiting | Johns Hopkins University | 9000 | 2014-01-06 | 2026-10-22 |
| Comparison of Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) to Endoscopic Pancreatic Function Test (ePFT) in Diagnosing Pancreatic Exocrine Insufficiency Synthetic Human Secretin - Pancreatic Cancer | Not applicable | Withdrawn | Columbia University | 2012-06-01 | 2012-07-02 | |
| Pancreatic Perfusion Using Secretin and MRI Secretin - Chronic Pancreatitis | Phase 1 / Phase 2 | Unknown | University of Nottingham | 15 | 2012-06-01 | 2016-02-18 |
| Secretin-Assisted Computed Tomography Scan and Magnetic Resonance Imaging in Improving Pancreatic Tumor Conspicuity Secretin Synthetic Human (RG1068) - Pancreas Cancer | Early Phase 1 | Withdrawn | University Hospitals Cleveland Medical Center | 2011-06-01 | 2022-06-16 | |
| Secretin Infusion for Pain Due to Chronic Pancreatitis Human Secretin - Chronic Pancreatitis | Phase 1 / Phase 2 | Completed | ChiRhoClin, Inc. | 12 | 2010-12-01 | 2016-03-09 |
| Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers Secretin - Chronic Pancreatitis | Phase 1 | Completed | University of Nottingham | 12 | 2010-09-01 | 2011-10-14 |
| Secretin-enhanced Magnetic Resonance Imaging (S-MRI) for Pancreatic Cancer Detection Secretin - Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm | Not applicable | Withdrawn | Elizabeth Hecht | 2010-04-01 | 2016-06-10 | |
| A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Morphine, Neostigmine, 0.9% saline - Sphincter of Oddi Dysfunction | Phase 4 | Completed | University of Nottingham | 10 | 2009-01-01 | 2010-06-02 |
| Safety and Efficacy of Synthetic Human Secretin-Enhanced MRCP in Subjects With Abnormalities of the Pancreas RG1068 (synthetic human secretin) - Pancreatitis | Phase 3 | Completed | Repligen Corporation | 258 | 2008-03-01 | 2009-12-03 |
Showing 20 of 31. Sign in to see all of them.
Pancreatic Neoplasms (9) · Pancreatitis, Chronic (6) · Pancreatitis (4) · Autistic Disorder (3) · Diabetes Mellitus (3) · Exocrine Pancreatic Insufficiency (3) · Peutz-Jeghers Syndrome (3) · Obesity (2) · Abdominal Pain (1) · Breast Neoplasms (1) · Bronchiolitis Obliterans Syndrome (1) · Child Development Disorders, Pervasive (1) · Colorectal Neoplasms, Hereditary Nonpolyposis (1) · Dyspepsia (1) · Dysplastic Nevus Syndrome (1)
Mayo Clinic (4) · Massachusetts General Hospital (3) · Repligen Corporation (3) · University of Nottingham (3) · ChiRhoClin, Inc. (2) · Children's Hospital Medical Center, Cincinnati (2) · Columbia University (2) · Elizabeth Hecht (2) · Johns Hopkins University (2) · Dartmouth-Hitchcock Medical Center (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Fundacion Clinic per a la Recerca Biomédica (1) · Indiana University (1) · Orlando Health, Inc. (1) · Steno Diabetes Center Copenhagen (1)
United States (21) · United Kingdom (3) · Denmark (1) · Finland (1) · Spain (1)
Dushyant V Sahani (3) · Andrew Trout, MD (2) · Elizabeth Hecht, MD (2) · Harold Frucht, MD (2) · Abeed Chowdhury, MB ChB BSc MRCS (1) · Alan Unis, MD (1) · Anantha Shekhar, MD, PhD (1) · David R Jacoby, MD, PhD (1) · Dileep Lobo, MBBS DM FRCS (1) · Edward Goldson, MD (1) · Filip K Knop, Professor, MD (1) · Geraldine Dawson, PhD (1) · John Simpson (1) · John Simpson, PhD FRCS (1) · Maisam Abu-El-Haija, MD (1)
PMID 23200980, PMID 23548879, PMID 24906040, PMID 25481712, PMID 31197699, PMID 31676359, PMID 32036693, PMID 33161160, PMID 33602643, PMID 34149034, PMID 34158656, PMID 34806426, PMID 36764966, PMID 37811711, PMID 39556772
P01HD035465 (1), P01HD035468 (1), R01CA176828 (1), R01DK115950 (1), R01DK122280 (1), R01DK132346 (1), U01CA210170 (1), UL1TR002377 (1)