89 completed, 17 recruiting, 15 terminated, 15 unknown. 33 Phase 3, 30 Phase 2, 24 Not applicable, 22 Phase 4, 11 Phase 1.
Follow Exocrine Pancreatic Insufficiency: new trials by email Literature Review of Exocrine Pancreatic Insufficiency trials Research Report on Exocrine Pancreatic Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Study to Evaluate Microbial Versus Porcine Pancreatic Enzyme Therapy in Chronic Pancreatitis Dietary Supplement: Pancreatic enzyme preparation from microbial source that contains amylase (6650 DU), lipase (13000 FIP), and protease (7120 HUT, 15 SAPU, 3000 PC)., Standard of care porcine pancreatic enzyme preparation: amylase (8000 U), lipase (25000 U), and protease (1000 U) - Pancreatitis, Chronic, Exocrine Pancreatic Insufficiency (EPI) | Phase 3 | Recruiting | Asian Institute of Gastroenterology, India | 134 | 2026-10-12 | 2026-10-26 |
| A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency. NHS7108, Zenpep® - Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF) | Phase 2 | Recruiting | Aimmune Nestlé Health Science US R&D, LLC | 66 | 2026-10-01 | 2026-10-01 |
| A Study on the Efficacy of Different Doses of Oryz-Aspergillus Enzyme And Pancreatin Tablet in Treating Pancreatic Exocrine Insufficiency After Gastrointestinal Surgery High-dose group: Oryz-Aspergillus Enzyme and Pancreatin Tablet, Low-dose group: Oryz-Aspergillus Enzyme And Pancreatin Tablet - Pancreatic Exocrine Insufficiency, Adul | Not applicable | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 150 | 2026-09-18 | 2026-08-07 |
| Determine the Prevalence of Exocrine Pancreatic Insufficiency (EPI) in Pediatric and Adult Participants With Alagille Syndrome After Liver Transplantation Fecal Fat - Exocrine Pancreatic Insuficiency | Recruiting | Digestive Care, Inc. | 30 | 2026-08-03 | 2026-10-13 | |
| A Multicenter Clinical Study on Protein Absorption Efficiency in Patients With Pancreatic Exocrine Insufficiency in the ICU Short peptide, Protein - High-risk Patients With Pancreatic Exocrine Insufficiency, Enteral Nutrition Feeding | Phase 4 | Not yet recruiting | Shanghai 10th People's Hospital | 250 | 2026-07-01 | 2026-07-16 |
| IPEX Study: Pancreatic Exocrine Insufficiency as a Functional Marker of Disease Progression in Patients With IPMN Intraductal Papillary Mucinous Neoplasms, Pancreatic Exocrine Insufficiency | Not yet recruiting | A.O.U. Città della Salute e della Scienza | 600 | 2026-07-01 | 2026-04-16 | |
| Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy SIBO, Pancreatic Insufficiency | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 100 | 2026-04-30 | 2026-04-13 | |
| Phase 2 Study to Assess the Safety and Efficacy of ANG003 ANG003 Dose A, ANG003 Dose B, Creon - Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF) | Phase 2 | Recruiting | Anagram Therapeutics, Inc. | 113 | 2026-04-24 | 2026-10-06 |
| Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis Pancreatic Enzyme Replacement Therapy, Placebo, MBT1 - Chronic Pancreatitis, Recurrent Acute Pancreatitis | Phase 4 | Recruiting | Anna Evans Phillips | 80 | 2026-04-20 | 2026-09-11 |
| Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis Pancreatic enzyme capsules, Placebo - Acute Necrotizing Pancreatitis, Pancreatic Exocrine Insufficiency | Phase 3 | Recruiting | Asian Institute of Gastroenterology, India | 140 | 2026-04-10 | 2026-05-05 |
| Nutrition Intervention for Pancreatic Cancer Structured Lipid Medical Food - Pancreatic Ductal Adenocarcinoma (PDAC), Pancreatic Neuroendocrine Tumor (NET) | Not applicable | Recruiting | Children's Hospital of Philadelphia | 18 | 2026-04-07 | 2026-05-07 |
| A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy Subjects Secretin (human synthetic) - ChiRhoClin - Exocrine Pancreatic Insufficiency, Chronic Pancreatitis | Phase 4 | Active not recruiting | Mayo Clinic | 24 | 2026-03-11 | 2026-10-26 |
| Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis Dorzagliatin, Placebo - Pancreatic Insufficiency, Cystic Fibrosis-related Diabetes | Phase 1 | Recruiting | Michael R. Rickels, MD, MS | 15 | 2025-10-21 | 2026-08-31 |
| PERT in Acute Necrotizing Pancreatitis Pancreatic Enzyme Replacement Therapy, Placebo - Acute Pancreatitis Necrotizing, Nutrition Assessment | Phase 3 | Not yet recruiting | Asian Institute of Gastroenterology, India | 188 | 2025-10-01 | 2025-10-08 |
| Fatty Liver and Pancreatic Steatosis Fecal elastase, Ecoendoscopy, Fibroscan - Exocrine Pancreatic Insufficiency, Fatty Liver, Nonalcoholic | Not yet recruiting | Maria Marta Piskorz | 61 | 2025-09-01 | 2025-08-06 | |
| Exocrine Pancreatic Insufficiency and Functional Dyspepsia fecal elastase, Serum cytokines - Exocrine Pancreatic Insufficiency, Dyspepsia | Not yet recruiting | Maria Marta Piskorz | 65 | 2025-09-01 | 2025-08-08 | |
| Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes Pancreatogenic Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM) | Recruiting | West Kazakhstan Marat Ospanov Medical University | 310 | 2025-07-07 | 2026-04-06 | |
| Evaluating the Utility of RELiZORB™ for Treating Feeding Intolerance in Critically Ill Adults With Multi-Organ Failure RELiZORB™, Placebo - Multi Organ Failure, Exocrine Pancreatic Insufficiency | Not applicable | Active not recruiting | Inova Health Care Services | 32 | 2025-05-07 | 2026-10-13 |
| Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis Patients RELiZORB - Exocrine Pancreatic Insufficiency (EPI), Pancreatitis | Phase 3 | Recruiting | Massachusetts General Hospital | 60 | 2025-03-28 | 2026-05-15 |
| Safety of Stopping Pancreatic Enzyme Replacement Therapy in Children With Improved Pancreatic Function After Highly Effective Modulator Therapy Discontinuation of Pancreatic Enzyme Replacement Therapy - Cystic Fibrosis (CF), Pancreatic Insufficiency | Phase 4 | Completed | Indiana University | 17 | 2024-12-03 | 2026-07-02 |
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Cystic Fibrosis (55) · Pancreatitis, Chronic (29) · Shwachman-Diamond Syndrome (21) · Anemia, Diamond-Blackfan (14) · Neutropenia, Severe Congenital, Autosomal Recessive 3 (11) · Anemia, Sickle Cell (10) · Diabetes Mellitus (10) · Anemia, Aplastic (9) · Steatorrhea (9) · Pancreatic Neoplasms (8) · Dyskeratosis Congenita (7) · Fanconi Anemia (7) · Pancreatitis (7) · Bone Marrow Failure Disorders (6)
Digestive System Diseases (151) · Pancreatic Diseases (150) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (75) · Genetic Diseases, Inborn (74) · Infant, Newborn, Diseases (60) · Lung Diseases (56) · Respiratory Tract Diseases (56) · Pathological Conditions, Signs and Symptoms (51) · Nutritional and Metabolic Diseases (48) · Pathologic Processes (43) · Metabolic Diseases (42) · Disease Attributes (39) · Chronic Disease (35) · Pancreatitis (27) · Endocrine System Diseases (24)
Pancrelipase (30) · liprotamase lipase (8) · fludarabine phosphate (7) · Antilymphocyte Serum (4) · Peripheral Blood Stem Cell Transplantation (4) · Tacrolimus (4) · Whole-Body Irradiation (4) · Busulfan (3) · Cyclophosphamide (3) · Methotrexate (3) · Pancreatin (3) · Secretin (3) · Alemtuzumab (2) · Bone Marrow Transplantation (2) · Glucose Tolerance Test (2)
Forest Laboratories (12) · Anthera Pharmaceuticals (8) · AbbVie (6) · Changhai Hospital (6) · Abbott (5) · Digestive Care, Inc. (5) · Solvay Pharmaceuticals (5) · Children's Hospital of Philadelphia (4) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (4) · Abbott Products (3) · Asian Institute of Gastroenterology, India (3) · Emory University (3) · Entero Therapeutics (3) · Masonic Cancer Center, University of Minnesota (3) · University of Pennsylvania (3)
United States (88) · Poland (14) · Spain (13) · China (11) · Hungary (11) · Italy (9) · Canada (8) · United Kingdom (8) · Germany (7) · Czechia (6) · Israel (5) · Russia (5) · Turkey (Türkiye) (5) · Australia (4) · Belgium (4)
Averell Sherker, MD (3) · Ed Doo, MD (3) · Rupjyoti Talukdar, MD (3) · Suntje Sander-Struckmeier, PhD (3) · Diane George, MD (2) · Guenter Krause, MD (2) · Harold Frucht, MD (2) · Michael R Rickels, MD, MS (2) · Monica Gangal (2) · Toshiaki Yamaguchi, BS Pharm (2) · Virginia A Stallings, MD (2)
PMID 32761612, PMID 29889111, PMID 27050056, PMID 32384122, PMID 35704255, PMID 37671264, PMID 11059056, PMID 16678560, PMID 17685472, PMID 19683970, PMID 19815466, PMID 20171415, PMID 20495625, PMID 20541625, PMID 21681115, PMID 22687371, PMID 23100216, PMID 23924602, PMID 23929695, PMID 24345827, PMID 24518280, PMID 24618443, PMID 24713840, PMID 24786393, PMID 24886762, PMID 25019921, PMID 25066363, PMID 25304614, PMID 25333403, PMID 25405500, PMID 25425683, PMID 25689042, PMID 25963299, PMID 26095669, PMID 26254836, PMID 26299411, PMID 26465792, PMID 26772149, PMID 27013382, PMID 27297209, PMID 27846134, PMID 27941156, PMID 28052624, PMID 28159463, PMID 28280134, PMID 28404111, PMID 28471913, PMID 28700471, PMID 28808361, PMID 28868406
U01DK062456 (3), 2014 (2), 2004 (1), 2005 (1), 2009 (1), 2017 (1), 2023 (1), 2025 (1), P30CA015704 (1), P60DK020579 (1), R01DK095738 (1), R01DK140381 (1), R44DK060302 (1), U10HL069294 (1)