11 completed. 11 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 11 |
| Phase 2 | 1 | Completed 1 |
Follow Osteosarcoma: new trials by email Literature Review of Osteosarcoma trials Research Report on Osteosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of HS-20093 Versus Gemcitabine in Combination With Docetaxel in Treatment of Osteosarcoma After Previous Second-line Treatment Failure HS-20093, Gemcitabine combined with docetaxel - Osteosarcoma | Phase 3 | Completed | Hansoh BioMedical R&D Company | 122 | 2025-04-25 | 2026-10-19 |
| Perioperative Use of Tranexamic (TXA) in Bone Tumor Surgery Will Change in Blood Loss and Transfusion Requirements. Tranexamic acid injection, Saline - Ewing Sarcoma of Bone, Osteosarcoma | Phase 3 | Completed | Children's Cancer Hospital Egypt 57357 | 48 | 2021-08-02 | 2024-02-07 |
| Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy apatinib - Osteosarcoma, Metastasis | Phase 2 / Phase 3 | Completed | GUO WEI | 37 | 2016-03-01 | 2018-04-23 |
| Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma High Dose Methotrexate - Osteosarcoma | Phase 3 | Completed | The Hospital for Sick Children | 6 | 2010-10-01 | 2021-10-28 |
| Study in Localized and Disseminated Ewing Sarcoma Zoledronic acid, Busulfan, Treosulfan - Ewing's Sarcoma | Phase 3 | Completed | University Hospital Muenster | 907 | 2009-10-01 | 2019-10-22 |
| Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma Standard treatment (as per protocol ISG SSG III), Intensified chemotherapy - Ewing's Sarcoma | Phase 3 | Completed | Italian Sarcoma Group | 278 | 2009-01-22 | 2022-09-19 |
| Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy sodium thiosulfate, examination - Brain Tumor, Central Nervous System Tumor | Phase 3 | Completed | Children's Oncology Group | 131 | 2008-06-23 | 2023-11-09 |
| Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Fentanyl sublingual spray, Placebo - Cancer | Phase 3 | Completed | INSYS Therapeutics Inc | 130 | 2007-10-01 | 2014-03-05 |
| Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Cisplatin, Doxorubicin Hydrochloride, Etoposide - Localized Osteosarcoma, Metastatic Osteosarcoma | Phase 3 | Completed | Children's Oncology Group | 1334 | 2005-11-14 | 2023-06-07 |
| Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children Etoposide, Ifosfamide, Methotrexate, Doxorubicin, Methotrexate - Osteosarcoma, Localised High Grade Osteosarcoma of the Limbs | Phase 3 | Completed | Gustave Roussy, Cancer Campus, Grand Paris | 226 | 1994-06-01 | 2005-09-16 |
| Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chemotherapy in the Treatment of Non-Metastatic Osteosarcoma. A Pediatric Oncology Group Phase III Study pre-surgical chemotherapy - Osteosarcoma | Phase 3 | Completed | National Cancer Institute (NCI) | 260 | 1987-05-01 | 2008-03-04 |
Brain Neoplasms (2) · Medulloblastoma (2) · Neoplasm Metastasis (2) · Sarcoma (2) · Sarcoma, Ewing (2) · Testicular Neoplasms (2) · Adrenocortical Carcinoma (1) · Anus Neoplasms (1) · Appendiceal Neoplasms (1) · Astrocytoma (1) · Bile Duct Neoplasms (1) · Blast Crisis (1) · Breast Carcinoma In Situ (1) · Breast Neoplasms (1)
Neoplasms by Histologic Type (11) · Neoplasms, Bone Tissue (11) · Neoplasms, Connective Tissue (11) · Neoplasms, Connective and Soft Tissue (11) · Neoplasms (10) · Sarcoma (9) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Neoplastic Processes (3) · Adnexal Diseases (2) · Brain Diseases (2) · Central Nervous System Diseases (2) · Digestive System Diseases (2) · Digestive System Neoplasms (2) · Endocrine Gland Neoplasms (2)
Doxorubicin (3) · Methotrexate (3) · Busulfan (2) · Etoposide (2) · Ifosfamide (2) · 1,2-diaminocyclohexaneplatinum II citrate (1) · Cisplatin (1) · Cyclophosphamide (1) · Dactinomycin (1) · Diphosphonates (1) · Docetaxel (1) · Fentanyl (1) · Fluoridation (1) · IMVP-16 protocol (1) · Melphalan (1)
Children's Oncology Group (2) · Children's Cancer Hospital Egypt 57357 (1) · GUO WEI (1) · Gustave Roussy, Cancer Campus, Grand Paris (1) · Hansoh BioMedical R&D Company (1) · INSYS Therapeutics Inc (1) · Italian Sarcoma Group (1) · National Cancer Institute (NCI) (1) · The Hospital for Sick Children (1) · University Hospital Muenster (1)
United States (4) · Canada (3) · Australia (2) · China (2) · Egypt (1) · France (1) · Germany (1) · Italy (1) · New Zealand (1) · Puerto Rico (1) · Switzerland (1)
Abha Gupta, MD (1) · Alan W Craft, Prof Sir MD (1) · Chantal Kalifa, MD (1) · David R. Freyer, DO, MS (1) · Larry Dillaha, MD (1) · Neyssa M Marina (1) · Roberto Luksch, MD (1) · Uta Dirksen, Prof MD (1) · Wei Guo, M.D. Ph.D. (1)
PMID 31401903, PMID 17267204, PMID 22480131, PMID 25421877, PMID 26271204, PMID 27020837, PMID 27569442, PMID 27914822, PMID 31553693, PMID 35246418, PMID 35427190, PMID 38524902, PMID 39796745, PMID 39833645
2004 (1), 2008 (1), U10CA098543 (1), U10CA180886 (1)