835 completed, 278 recruiting, 198 unknown, 163 terminated. 668 Phase 2, 407 Phase 1, 214 Not applicable, 158 Phase 3, 38 Phase 4.
Follow Neoplasms, Connective Tissue: new trials by email Literature Review of Neoplasms, Connective Tissue trials Research Report on Neoplasms, Connective Tissue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neoadjuvant Pimicotinib Combined With Surgery Versus Upfront Surgery for Diffuse Tenosynovial Giant Cell Tumor Pimicotinib, Tumor resection surgery - Tenosynovial Giant Cell Tumor, Diffuse | Phase 2 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 84 | 2027-10-01 | 2026-07-16 |
| GD2IL18CART Combined With Bevacizumab for Relapsed and Refractory GD2-positive Solid Tumors Chimeric Antigen Receptor (CAR) Therapy Infusion, Bevacizumab (Avastin) - Neuroblastoma (NBL), Ewing Sarcoma | Phase 1 | Not yet recruiting | Universität Münster | 30 | 2027-10-01 | 2026-11-03 |
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-11-02 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-10-30 |
| A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat Archive Sample Retrieval, Biospecimen Collection, pH Low Insertion Peptide-exatecan Conjugate CBX-12 - Recurrent Childhood Ewing Sarcoma, Recurrent Childhood Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 79 | 2027-05-07 | 2026-09-22 |
| Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors Aldesleukin, Biospecimen Collection, Chest Radiography - Locally Advanced Gastrointestinal Stromal Tumor, Metastatic Gastrointestinal Stromal Tumor | Phase 2 | Not yet recruiting | Joal Beane | 59 | 2027-02-15 | 2026-10-13 |
| Doxorubicin With or Without DT-7012 in Advanced Soft Tissue Sarcoma DT-7012, Doxorubicin - Undifferentiated Pleomorphic Sarcoma (UPS), Dedifferentiated Liposarcoma (DDLPS) | Phase 2 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 80 | 2027-02-01 | 2026-09-15 |
| RAPID: Phase 2 Platform Trial Of Promising Drugs For AYA Patients With R/R Ewing Sarcoma & DSRCT LX-101 - Ewing Sarcoma | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 120 | 2027-02-01 | 2026-08-24 |
| A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). ST316 IV - Familial Adenomatous Polyposis (FAP) | Phase 1 | Not yet recruiting | Sapience Therapeutics | 40 | 2027-01-04 | 2026-08-12 |
| Hyperpolarized MRI for GIST on Imatinib Hyperpolarized 13C-MRI - Imatinib Therapy Response, Gastrointestinal Stromal Tumor (GIST) | Not yet recruiting | Chang Gung Memorial Hospital | 30 | 2027-01-01 | 2026-07-24 | |
| Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor avutometinib capsule + defactinib tablet - MPNST (Malignant Peripheral Nerve Sheath Tumor) | Phase 2 | Not yet recruiting | Girish Dhall, MD | 25 | 2027-01-01 | 2026-10-28 |
| Mercaptopurine for the Treatment of Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), Uterine/Cutaneous Leiomyomas, and Kidney Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Kidney Carcinoma, Advanced Renal Cell Carcinoma | Phase 1 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 18 | 2026-12-01 | 2026-08-06 |
| Testing the Anti-Cancer Drug, Brenetafusp (IMCF106C), in Rare Cancers Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C, Biopsy Procedure, Biospecimen Collection - Metastatic Myxoid Liposarcoma, Metastatic Synovial Sarcoma | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 42 | 2026-11-23 | 2026-09-25 |
| my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults my.naviGATE Digital Tool - Sarcoma, Osteosarcoma | Not applicable | Not yet recruiting | Dana-Farber Cancer Institute | 143 | 2026-11-20 | 2026-10-29 |
| DEPART Study at Yale Radiation Therapy - Dupuytren's Contracture | Phase 3 | Not yet recruiting | Yale University | 158 | 2026-11-01 | 2026-10-13 |
| Management of Breast Fibroadenoma: Comparing Observation, Microwave Ablation, and Surgical Excision Ultrasound-guided percutaneous microwave ablation, Conventional open surgical excision - Fibroadenoma, Breast Fibroadenoma | Not applicable | Not yet recruiting | Sohag University | 60 | 2026-11-01 | 2026-10-22 |
| A Study of DCC-3014 to Evaluate the Efficacy, Safety, and Pharmacokinetics in Subjects With TGCT DCC-3014 - Tenosynovial Giant Cell Tumor | Phase 2 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 18 | 2026-10-31 | 2026-09-22 |
| The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma High-dose Methotrexate - Osteosarcoma in Children, Osteosarcoma in Adolescents and Young Adults | Phase 2 | Recruiting | Wake Forest University Health Sciences | 46 | 2026-10-31 | 2026-11-04 |
| Synovial Tissue as a Biomarker in the Management of Pigmented Villonodular Synovitis synovial biopsy - Synovitis Villonodular | Not applicable | Recruiting | Nantes University Hospital | 30 | 2026-10-30 | 2026-11-06 |
| Understanding Patient Preferences When Deciding on a Voluntary Musculoskeletal Test Diagnostic Advance Care Planning Discussion, Informational Statement Only - Non-traumatic Musculoskeletal Conditions, Carpal Tunnel Syndrome (CTS) | Not applicable | Not yet recruiting | University of Texas at Austin | 220 | 2026-10-25 | 2026-09-22 |
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Osteosarcoma (472) · Sarcoma (397) · Gastrointestinal Stromal Tumors (335) · Sarcoma, Ewing (245) · Rhabdomyosarcoma (156) · Neuroblastoma (147) · Sarcoma, Synovial (133) · Myofibroma (120) · Ovarian Neoplasms (108) · Neoplasms (104) · Neurofibrosarcoma (97) · Chondrosarcoma (93) · Histiocytoma, Malignant Fibrous (91) · Leiomyosarcoma (89) · Liposarcoma (87)
Neoplasms by Histologic Type (1730) · Neoplasms, Connective and Soft Tissue (1727) · Neoplasms (1631) · Neoplasms, Bone Tissue (646) · Sarcoma (506) · Neoplasms by Site (501) · Neoplasms, Fibrous Tissue (446) · Digestive System Diseases (435) · Digestive System Neoplasms (419) · Neoplasms, Glandular and Epithelial (419) · Gastrointestinal Diseases (392) · Skin and Connective Tissue Diseases (373) · Gastrointestinal Neoplasms (364) · Neoplasms, Nerve Tissue (361)
Imatinib Mesylate (85) · Cyclophosphamide (64) · Doxorubicin (64) · Ifosfamide (52) · Cisplatin (40) · Carboplatin (37) · Radiotherapy (37) · Sunitinib (35) · Etoposide (34) · Gemcitabine (32) · Methotrexate (31) · Paclitaxel (31) · Filgrastim (30) · Temozolomide (30) · Magnetic Resonance Spectroscopy (29)
National Cancer Institute (NCI) (137) · Children's Oncology Group (41) · M.D. Anderson Cancer Center (39) · Memorial Sloan Kettering Cancer Center (38) · Peking University People's Hospital (36) · Novartis Pharmaceuticals (33) · Istituto Ortopedico Rizzoli (28) · European Organisation for Research and Treatment of Cancer - EORTC (24) · St. Jude Children's Research Hospital (23) · Gynecologic Oncology Group (20) · Asan Medical Center (18) · Mayo Clinic (17) · Blueprint Medicines Corporation (16) · Dana-Farber Cancer Institute (16) · Italian Sarcoma Group (16)
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AeRang Kim, MD, PhD (7) · Brigitte C Widemann, M.D. (6) · Silvia Stacchiotti, MD (6) · Yoon-Koo Kang, MD, PhD (6) · Ilse Degreef, Prof. Dr. (5) · Richard Gorlick, MD (5) · Suzanne George, MD (5)
PMID 31401903, PMID 37185961, PMID 30274985, PMID 17046465, PMID 22682017, PMID 32615108, PMID 33465704, PMID 35790816, PMID 12094370, PMID 14645423, PMID 16624552, PMID 18076015, PMID 18774375, PMID 19451433, PMID 21134978, PMID 21345435, PMID 21387287, PMID 21613624, PMID 21826194, PMID 21941283, PMID 23177515, PMID 23450030, PMID 24444087, PMID 25421877, PMID 25655899, PMID 27355533, PMID 27567955, PMID 28385194, PMID 28947860, PMID 29033609, PMID 29093181, PMID 30477937, PMID 30617491, PMID 30633128, PMID 31013172, PMID 31188797, PMID 31553693, PMID 32002290, PMID 32192573, PMID 32224746, PMID 32269142, PMID 32511981, PMID 32827353, PMID 33289960, PMID 33301227, PMID 33453089, PMID 33461754, PMID 34272196, PMID 34343033, PMID 34416158
U10CA180886 (25), U10CA098543 (23), U10CA027469 (17), U10CA032102 (12), 2023 (11), 2015 (10), U10CA180868 (10), P30CA008748 (9), U10CA031946 (9), P30CA033572 (7), 2008 (6), 2009 (6), 2018 (6), U10CA180821 (6), UM1CA228823 (6)