25 completed, 11 unknown, 10 recruiting, 6 active not recruiting. 29 Phase 3, 21 Phase 2, 3 Not applicable, 3 Phase 1, 1 Phase 4.
Follow Dactinomycin: new trials by email Literature Review of Dactinomycin trials Research Report on Dactinomycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS) Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Rhabdomyosarcoma | Phase 3 | Recruiting | Children's Oncology Group | 342 | 2026-07-14 | 2026-08-25 |
| Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes Vincristine, Doxorubicin, Cyclophosphamide - Metastatic Ewing Sarcoma | Phase 1 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 15 | 2026-02-05 | 2026-09-25 |
| A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT) Bone Scan, Carboplatin, Computed Tomography - Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor | Phase 3 | Recruiting | Children's Oncology Group | 1656 | 2025-04-15 | 2026-08-25 |
| Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma Biospecimen Collection, Bone Scan, Computed Tomography - Pleuropulmonary Blastoma | Phase 3 | Recruiting | Children's Oncology Group | 110 | 2025-03-21 | 2026-08-25 |
| Toripalimab Plus Actinomycin-D As Fist-Line Treatment for GTN with FIGO Score 7 Toripalimab, Actinomycin-D - Gestational Trophoblastic Neoplasia | Phase 2 | Recruiting | Peking Union Medical College Hospital | 17 | 2024-12-01 | 2024-12-31 |
| Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease Vincristine, Dactinomycin, Cyclophosphamide - Rhabdomyosarcoma | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 135 | 2024-03-13 | 2026-06-15 |
| Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 5-6 Toripalimab, Actinomycin-D - Gestational Trophoblastic Neoplasia | Not applicable | Recruiting | Peking Union Medical College Hospital | 40 | 2023-09-12 | 2025-02-06 |
| Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma Biopsy Procedure, Bone Scan, Computed Tomography - Embryonal Rhabdomyosarcoma, Fusion-Negative Alveolar Rhabdomyosarcoma | Phase 3 | Recruiting | Children's Oncology Group | 205 | 2022-08-04 | 2026-08-25 |
| A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Alveolar Rhabdomyosarcoma, Botryoid-Type Embryonal Rhabdomyosarcoma | Phase 3 | Active not recruiting | Children's Oncology Group | 113 | 2021-09-14 | 2026-07-30 |
| Evolutionary Therapy for Rhabdomyosarcoma Vincristine, Cyclophosphamide, Vinorelbine - Rhabdomyosarcoma | Phase 2 | Active not recruiting | H. Lee Moffitt Cancer Center and Research Institute | 12 | 2020-12-29 | 2025-11-26 |
| Biweekly Actinomycin-D Treatment or Multi-day Methotrexate Protocol in Low-risk Gestational Trophoblastic Neoplasia Methotrexate, Leucovorin, Dactinomycin - Gestational Trophoblastic Tumor, Gestational Trophoblastic Neoplasia | Not applicable | Active not recruiting | xiang yang | 228 | 2020-09-29 | 2025-08-11 |
| FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma Irinotecan, Actinomycin D, Doxorubicin - Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University of Birmingham | 1672 | 2020-09-17 | 2024-05-23 |
| A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg Isolated Limb Infusion, Pembrolizumab, infusion of melphalan and dactinomycin - Sarcoma, Myxofibrosarcoma | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 30 | 2020-04-01 | 2026-04-23 |
| Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma Cyclophosphamide, Dactinomycin, Irinotecan Hydrochloride - Alveolar Rhabdomyosarcoma, Botryoid-Type Embryonal Rhabdomyosarcoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 325 | 2016-06-01 | 2026-10-01 |
| Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Etoposide, actinomycin D, methotrexate - Gestational Trophoblastic Neoplasms | Phase 3 | Unknown | Weiguo Lv | 214 | 2016-03-01 | 2022-06-03 |
| Isolated Limb Infusion Chemotherapy With Targeted Gene Therapy for Advanced, Unresectable Extremity Melanoma dactinomycin, melphalan, Conditionally replicative adenovirus 3/5-delta - Melanoma | Phase 1 / Phase 2 | Withdrawn | Washington University School of Medicine | 2014-12-01 | 2014-07-18 | |
| Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy Vincristine, Dactinomycin, Cyclophosphamide - Rhabdomyosarcoma | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 115 | 2013-12-04 | 2026-06-17 |
| Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia MTX 1, MTX 2, Act-d - Gestational Trophoblastic Disease, Gestational Trophoblastic Neoplasia | Phase 3 | Unknown | Ding Ma | 300 | 2012-12-01 | 2019-12-24 |
| Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Dactinomycin, Leucovorin Calcium, Methotrexate - Choriocarcinoma, FIGO Stage I Gestational Trophoblastic Tumor | Phase 3 | Completed | GOG Foundation | 57 | 2012-06-18 | 2022-08-12 |
| Addition of Ipilimumab (MDX-010) To Isolated Limb Infusion (ILI) With Standard Melphalan and Dactinomycin In The Treatment of Advanced Unresectable Melanoma of The Extremity Ipilimumab, Melphalan and Dactinomycin - Melanoma | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 26 | 2011-02-01 | 2018-05-15 |
Showing 20 of 55. Sign in to see all of them.
Sarcoma (17) · Rhabdomyosarcoma (14) · Wilms Tumor (9) · Malignant mesenchymal tumor (7) · Gestational Trophoblastic Disease (6) · Kidney Neoplasms (5) · Neuroectodermal Tumors, Primitive, Peripheral (4) · Fibrosarcoma (3) · Melanoma (3) · Rhabdomyosarcoma, Embryonal (3) · Choriocarcinoma (2) · Desmoplastic Small Round Cell Tumor (2) · Hemangiopericytoma, Malignant (2) · Hemangiosarcoma (2) · Hydatidiform Mole (2)
Children's Oncology Group (18) · Memorial Sloan Kettering Cancer Center (5) · University of Leicester (3) · Gynecologic Oncology Group (2) · H. Lee Moffitt Cancer Center and Research Institute (2) · Japan Rhabdomyosarcoma Study Group (2) · National Cancer Institute (NCI) (2) · Peking Union Medical College Hospital (2) · Societe Internationale d'Oncologie Pediatrique (2) · St. Jude Children's Research Hospital (2) · Children's Cancer and Leukaemia Group (1) · Children's Hospitals and Clinics of Minnesota (1) · Dana-Farber Cancer Institute (1) · Ding Ma (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1)
United States (37) · Canada (21) · Australia (19) · New Zealand (18) · Puerto Rico (14) · Switzerland (11) · United Kingdom (9) · Netherlands (7) · China (5) · France (4) · Ireland (4) · Israel (4) · Belgium (3) · Denmark (3) · Italy (3)
Elizabeth A Mullen (3) · Alan W. Craft, MD (2) · Daniel M. Green, MD (2) · Hajime Hosoi (2) · Heribert F. Juergens, MD (2) · Jan DeKraker, MD (2) · Jonathan Metts, MD (2) · Abha A Gupta (1) · Alberto Pappo, MD (1) · Alberto S. Pappo, MD (1) · Allan Covens, MD (1) · Annabel B.M. Foot (1) · Anne B. Warwick, MD, MPH (1) · Brenda Weigel, MD (1) · Carola A Arndt, MD (1)
PMID 38603649, PMID 31449468, PMID 37933882, PMID 10463285, PMID 15175957, PMID 15542800, PMID 15654272, PMID 15868587, PMID 16129848, PMID 16172460, PMID 16410127, PMID 16547940, PMID 16572419, PMID 16710034, PMID 16900525, PMID 17084075, PMID 17264331, PMID 17539021, PMID 18802150, PMID 18811224, PMID 18989885, PMID 19064966, PMID 19208794, PMID 19231157, PMID 19282789, PMID 19300220, PMID 19760772, PMID 20308673, PMID 20332316, PMID 20338746, PMID 20547982, PMID 20582946, PMID 21189373, PMID 21357783, PMID 21703848, PMID 22104356, PMID 22665534, PMID 22952427, PMID 23382471, PMID 24982464, PMID 27811504, PMID 29211618, PMID 29610659, PMID 29659330, PMID 30091945, PMID 31174239, PMID 31553693, PMID 32460997, PMID 34722269, PMID 35072864
U10CA180886 (11), U10CA098543 (8), U10CA027469 (2), 2018 (1), P30CA006516 (1), P30CA008748 (1), U10CA180868 (1)