117 completed, 44 recruiting, 30 terminated, 30 unknown. 271 Phase 2, 70 Phase 1, 6 Phase 3.
Follow Osteosarcoma: new trials by email Literature Review of Osteosarcoma trials Research Report on Osteosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-11-02 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-10-30 |
| A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat Archive Sample Retrieval, Biospecimen Collection, pH Low Insertion Peptide-exatecan Conjugate CBX-12 - Recurrent Childhood Ewing Sarcoma, Recurrent Childhood Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 79 | 2027-05-07 | 2026-09-22 |
| RAPID: Phase 2 Platform Trial Of Promising Drugs For AYA Patients With R/R Ewing Sarcoma & DSRCT LX-101 - Ewing Sarcoma | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 120 | 2027-02-01 | 2026-08-24 |
| The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma High-dose Methotrexate - Osteosarcoma in Children, Osteosarcoma in Adolescents and Young Adults | Phase 2 | Recruiting | Wake Forest University Health Sciences | 46 | 2026-10-31 | 2026-11-04 |
| Phase I/II Trial of Dinutuximab Beta in Combination With Irinotecan and Rapamycin in Pediatric, Adolescents and Adult Patients With Relapsed/Refractory Bone Tumors. Dinutuximab beta, Sirolimus and Irinotecan - Osteosarcomas, Bone Cancer | Phase 1 / Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 89 | 2026-10-01 | 2026-10-01 |
| A Study to Assess Safety and Efficacy of SOT106 in Patients With LRRC15-positive Advanced Unresectable or Metastatic Osteosarcoma or Soft Tissue Sarcoma SOT106 - Osteosarcoma Metastatic, Soft Tissue Sarcoma (STS) | Phase 1 / Phase 2 | Not yet recruiting | SOTIO Biotech a.s. | 70 | 2026-09-30 | 2026-09-03 |
| Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled Trial Psilocybin (high dose), Psilocybin (low dose), PEARL Therapy - Advanced Cancer, Stage IV Solid Tumor Cancer | Phase 2 | Not yet recruiting | University Health Network, Toronto | 46 | 2026-09-14 | 2026-10-15 |
| Evaluating Efficacy of B7-H3-CAR T Cells Administered at the End of Upfront Map Chemotherapy in Patients With Newly Diagnosed High-Risk Osteosarcoma Cyclophosphamide, Fludarabine, Mesna - Pediatric Osteosarcoma | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 41 | 2026-08-21 | 2026-11-03 |
| Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma Domatinostat, Sirolimus - Sarcoma, Osteosarcoma | Phase 1 / Phase 2 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 74 | 2026-07-15 | 2026-09-03 |
| Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma Eflornithine, Topotecan, Cyclophosphamide - Osteosarcoma, Ewing Sarcoma | Phase 2 | Recruiting | Milton S. Hershey Medical Center | 406 | 2026-06-05 | 2026-10-06 |
| Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas Eflornithine (DFMO), AMXT 1501 Dicaprate - Atypical Teratoid/Rhabdoid Tumor, Embryonal Tumor With Multilayered Rosettes | Phase 1 / Phase 2 | Recruiting | Milton S. Hershey Medical Center | 265 | 2026-05-13 | 2026-09-03 |
| Evaluation of the Safety and Efficacy of Mifamurtide Versus Standard Treatment With Sorafenib in Patients With High-risk Osteosarcoma Mifamurtide, Sorafenib - Osteosarcoma | Phase 2 | Recruiting | Anna Raciborska | 40 | 2026-04-01 | 2026-10-07 |
| A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma Methotrexate, Doxorubicin, Cisplatin - Osteosarcoma, Metastasis | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 45 | 2026-03-11 | 2026-03-17 |
| Apatinib Combined With Liposomal Irinotecan for Refractory or Metastatic Osteosarcoma Liposomal Irinotecan, Apatinib in arm1 - Osteosarcoma, Osteosarcoma Metastatic | Phase 1 / Phase 2 | Recruiting | Peking University People's Hospital | 56 | 2026-03-05 | 2026-03-18 |
| Liposomal Irinotecan, Vincristine, Temozolomide, and Anlotinib for R/R Pediatric Solid Tumors Liposomal Irinotecan, Vincristine, Temozolomide, and Optional Anlotinib - Relapsed or Refractory Pediatric Malignant Solid Tumors (Including Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma, Osteosarcoma) | Phase 2 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 33 | 2026-03-01 | 2026-03-03 |
| Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors Miltenyi CliniMACS Prodigy ® system, Zoledronic acid - Neuroblastoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University of Florida | 27 | 2026-02-11 | 2026-06-30 |
| Lu-TARGO (177Lu-TARGeted Osteosarcoma Therapy) LNTH2403 Phase 1 dose, Phase 2; LNTH2403 a single agent recommended phase 2 dose (RP2D). - Relapsed / Refractory Osteosarcoma | Phase 1 / Phase 2 | Recruiting | Lantheus Medical Imaging | 55 | 2026-02-03 | 2026-05-01 |
| Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - CIC-Rearranged Sarcoma, Metastatic Ewing Sarcoma | Phase 2 / Phase 3 | Terminated | Children's Oncology Group | 2 | 2025-11-10 | 2026-10-05 |
| Envafolimab Combined With Neoadjuvant Chemotherapy Treat Stage IIb Resectable Osteosarcoma Patients Envafolimab and neoadjuvant chemotherapy - Osteosarcoma, Neoadjuvant Therapy | Phase 2 | Not yet recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 23 | 2025-08-25 | 2025-08-27 |
Showing 20 of 271. Sign in to see all of them.
Sarcoma (113) · Sarcoma, Ewing (111) · Rhabdomyosarcoma (70) · Neuroblastoma (59) · Neuroectodermal Tumors, Primitive, Peripheral (43) · Wilms Tumor (32) · Medulloblastoma (29) · Hepatoblastoma (25) · Bone Neoplasms (22) · Rhabdoid Tumor (22) · Ependymoma (21) · Chondrosarcoma (20) · Glioma (19) · Recurrence (19)
Neoplasms by Histologic Type (271) · Neoplasms, Bone Tissue (270) · Neoplasms, Connective Tissue (270) · Neoplasms, Connective and Soft Tissue (269) · Neoplasms (259) · Sarcoma (158) · Neoplasms, Glandular and Epithelial (91) · Neoplasms, Nerve Tissue (91) · Neoplasms, Germ Cell and Embryonal (87) · Neuroectodermal Tumors (86) · Neoplasms by Site (83) · Neoplasms, Muscle Tissue (81) · Neoplasms, Neuroepithelial (80) · Myosarcoma (72) · Neuroectodermal Tumors, Primitive (72)
Ifosfamide (24) · Doxorubicin (23) · Cyclophosphamide (19) · Temozolomide (16) · Etoposide (15) · Irinotecan (15) · Methotrexate (15) · Vincristine (15) · Cisplatin (14) · Filgrastim (12) · Gemcitabine (11) · Magnetic Resonance Spectroscopy (9) · Nivolumab (9) · Sirolimus (9) · Specimen Handling (9)
National Cancer Institute (NCI) (41) · Memorial Sloan Kettering Cancer Center (16) · M.D. Anderson Cancer Center (13) · Children's Oncology Group (10) · Peking University People's Hospital (10) · St. Jude Children's Research Hospital (9) · Sarcoma Alliance for Research through Collaboration (6) · Dana-Farber Cancer Institute (5) · Eli Lilly and Company (5) · Grupo Espanol de Investigacion en Sarcomas (5) · Italian Sarcoma Group (5) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (4) · City of Hope Medical Center (3) · Eisai Inc. (3) · Merck Sharp & Dohme LLC (3)
United States (169) · China (36) · Canada (29) · France (27) · Italy (24) · Spain (22) · Puerto Rico (18) · Australia (16) · Germany (16) · United Kingdom (13) · Poland (8) · South Korea (8) · Netherlands (7) · Belgium (5) · Brazil (5)
Richard Gorlick, MD (4) · Antonio Casado (3) · Brian H. Kushner, MD (3) · Claudia Valverde (3) · Josefina Cruz (3) · Robert Maki, MD, PhD (3) · Weibin Zhang, PhD, MD (3) · AeRang Kim, MD, PhD (2) · Anna Raciborska, Prof. (2) · David Shulman, MD (2) · Eugenie S. Kleinerman, MD (2) · Fariba Navid, MD (2)
PMID 31401903, PMID 19451433, PMID 22682017, PMID 30477937, PMID 31013172, PMID 32192573, PMID 34416158, PMID 16314647, PMID 16435380, PMID 16532433, PMID 18676758, PMID 19338063, PMID 19451429, PMID 20226028, PMID 20576718, PMID 20715156, PMID 20943374, PMID 21896345, PMID 22067397, PMID 22088484, PMID 22251554, PMID 22347360, PMID 22363068, PMID 23255417, PMID 23382028, PMID 23477833, PMID 24089446, PMID 24637635, PMID 25374341, PMID 25498219, PMID 26181034, PMID 27362300, PMID 27932229, PMID 28295221, PMID 28494338, PMID 28662235, PMID 28735378, PMID 29445029, PMID 29487221, PMID 29544202, PMID 29931504, PMID 30410720, PMID 30777875, PMID 31110092, PMID 31442817, PMID 31553693, PMID 31586757, PMID 31838007, PMID 31987969, PMID 32078813
U10CA180886 (19), U10CA098543 (12), 2023 (5), P30CA008748 (5), UM1CA228823 (4), P30CA033572 (3), 2009 (2), 2016 (2), 2017 (2), 2019 (2), P30CA060553 (2), UM1CA097452 (2), 2004 (1), 2014 (1), 2015 (1)