15 completed, 2 terminated, 2 unknown, 1 recruiting. 6 Not applicable, 6 Phase 4, 5 Phase 3, 3 Phase 2, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Preoperative BOTOX® Injection for Large Ventral Hernia Repair OnabotulinumtoxinA Injection, Saline (placebo) Injection, OnabotulinumtoxinA - Hernia Abdominal Wall, Botox Injection | Phase 4 | Recruiting | The Cleveland Clinic | 188 | 2025-11-03 | 2026-10-26 |
| Dexmedetomidine Infusion on Intraoperative Propofol,Fentanyl Requirements in Spine Surgery for Pediatric Cancer Patients Precedex Injectable Product, Saline - Spine Cancer, Anesthesia | Phase 3 | Unknown | Children's Cancer Hospital Egypt 57357 | 38 | 2022-05-17 | 2022-08-09 |
| Treatment of Pruritus With Intramuscular Promethazine Promethazine, Placebo - Pruritus, Pregnancy Related | Phase 4 | Completed | University of Florida | 72 | 2021-08-09 | 2025-05-04 |
| Perioperative Use of Tranexamic (TXA) in Bone Tumor Surgery Will Change in Blood Loss and Transfusion Requirements. Tranexamic acid injection, Saline - Ewing Sarcoma of Bone, Osteosarcoma | Phase 3 | Completed | Children's Cancer Hospital Egypt 57357 | 48 | 2021-08-02 | 2024-02-07 |
| Tranexamic Acid Use to Reduce Blood Transfusion in Pediatric Cancer Patients Undergoing Limb Salvage Procedure Tranexamic Acid, 0.9% sodium chloride - Cancer of the Bone, Limb Salvage | Phase 3 | Terminated | St. Jude Children's Research Hospital | 15 | 2021-01-29 | 2024-12-20 |
| Efficacy of Mouthwash in Reducing Salivary Carriage of COVID-19 0.5% Povidone Iodine, 0.12% Chlorhexidine Gluconate Mouth Rinse, 1% Hydrogen Peroxide - COVID-19 | Phase 4 | Unknown | Ohio State University | 60 | 2020-10-01 | 2020-10-27 |
| Suprainguinal Fascia Iliaca (SIFI) Block Improves Analgesia Following Total Hip Arthroplasty Suprainguinal fascia iliaca (SIFI) block, Sham block, Ropivacaine - Hip Osteoarthritis, Primary Total Hip Arthroplasty | Phase 4 | Terminated | Duke University | 11 | 2017-08-01 | 2022-07-19 |
| Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Chloroprocaine, Bupivacaine, Fentanyl - Adverse Reaction to Spinal Anesthetic, Maternal Care for Cervical Incompetence | Phase 4 | Completed | Columbia University | 43 | 2016-11-08 | 2020-12-24 |
| Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients Methadone, Normal Saline, Morphine - Scoliosis, Pain | Phase 3 | Completed | Medical College of Wisconsin | 58 | 2016-02-01 | 2023-11-18 |
| Pilot RCT of Efficacy of Perineural Local Anesthetics and Steroids for Chronic Post-traumatic Ankle and Foot Pain 0.9% saline, 0.25% bupivacaine hydrochloride injectable suspension USP, 4mg/cc methylprednisolone acetate injectable suspension USP - CHRONIC POST-TRAUMATIC NEUROPATHIC PAIN IN ANKLE AND FOOT | Early Phase 1 | Completed | University Health Network, Toronto | 8 | 2015-11-01 | 2018-05-03 |
| Use of Pre-Emptive Pudendal Nerve Block for Pelvic Reconstructive Surgery pudendal block, no pudendal block - Pelvic Organ Prolapse | Not applicable | Withdrawn | Icahn School of Medicine at Mount Sinai | 2015-10-01 | 2017-04-25 | |
| Intranasal Bevacizumab for HHT-Related Epistaxis Bevacizumab, Placebo (Saline) - HHT, Hereditary Hemorrhagic Telangiectasia | Phase 4 | Completed | Stanford University | 40 | 2014-08-04 | 2021-09-01 |
| Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection Non invasive caries treatment, Invasive caries treatment, Near-infrared light transillumination device (DIAGNOcam, KaVo, Biberach, Germany) - Dental Caries | Not applicable | Completed | University of Bern | 35 | 2014-07-01 | 2016-08-18 |
| Effect of EPA and HMB on Strength in ICU Patients HMB, hydroxymethylbutyrate, EPA, eicosapentaenoic acid, Saline - Muscle Weakness | Not applicable | Completed | Gerald Supinski | 73 | 2014-01-01 | 2021-04-12 |
| Stool Transplant in Pediatric Patients With Recurring C. Difficile Infection FMT, placebo - Clostridium Difficile Colitis | Phase 2 | Completed | MemorialCare Health System | 9 | 2013-10-01 | 2016-09-01 |
| Effect of ASEA on Energy Expenditure and Fat Oxidation in Humans Salt Water, ASEA water - Obesity | Not applicable | Completed | University of North Carolina, Chapel Hill | 15 | 2012-11-01 | 2013-06-24 |
| Safety and Effectiveness Study of Intranasal Insulin Glulisine on Cognitive and Memory in Mild-Mod AD Patients. Insulin glulisine, Saline - Alzheimer's Disease | Phase 2 | Completed | HealthPartners Institute | 12 | 2011-09-01 | 2015-10-19 |
| Clearance Of Mucus In Stents (COMIS) Normal Saline, Sodium Bicarbonate - Lung Neoplasms, Respiratory Failure | Not applicable | Completed | M.D. Anderson Cancer Center | 43 | 2011-06-16 | 2023-08-25 |
| Role of Endorphins in Perception of Dyspnea With Resistive Loading in Chronic Obstructive Pulmonary Disease (COPD) naloxone, normal saline - Chronic Obstructive Pulmonary Disease | Not applicable | Completed | Dartmouth-Hitchcock Medical Center | 14 | 2009-08-01 | 2013-04-11 |
| The Impact of Botox® During Robotic Rehabilitation of the Wrist Following Stroke Botox®, saline solution - Stroke | Phase 1 / Phase 2 | Completed | New York Presbyterian Hospital | 12 | 2009-06-01 | 2011-04-26 |
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Pain (2) · Acute Coronary Syndrome (1) · Alzheimer Disease (1) · Angina, Unstable (1) · Arrhythmias, Cardiac (1) · Bone Neoplasms (1) · COVID-19 (1) · Dental Caries (1) · Enterocolitis, Pseudomembranous (1) · Epistaxis (1) · Hernia (1) · Hernia, Abdominal (1) · Hernia, Ventral (1) · Incisional Hernia (1) · Lower Extremity Deformities, Congenital (1)
Children's Cancer Hospital Egypt 57357 (2) · Columbia University (1) · Dartmouth-Hitchcock Medical Center (1) · Duke University (1) · Gerald Supinski (1) · HealthPartners Institute (1) · Icahn School of Medicine at Mount Sinai (1) · M.D. Anderson Cancer Center (1) · Medical College of Wisconsin (1) · MemorialCare Health System (1) · New York Presbyterian Hospital (1) · Ohio State University (1) · Shriners Hospitals for Children (1) · St. Jude Children's Research Hospital (1) · Stanford University (1)
United States (17) · Canada (2) · Egypt (2)
Adam Wendling, MD (1) · Andrew G Swick, PhD (1) · Anuj Bhatia, MD, FRCPC (1) · Carlos A. Jimenez, MD (1) · David L Hall, DDS (1) · Donald A Mahler, M.D. (1) · Gerald Supinski, MD (1) · Klaus W Neuhaus, PD (1) · Lucas R Beffa, MD (1) · Mamta Mamik, MD (1) · Michael D. Neel, MD (1) · Michael H Rosenbloom, MD (1) · Peter H Hwang, MD (1) · Reggie Hamdy, MD (1)
PMID 11050519, PMID 16597655, PMID 19568011, PMID 21513438, PMID 25971957, PMID 27334885, PMID 27521593, PMID 34153006, PMID 34446067, PMID 34561086, PMID 7848959