27 completed, 4 recruiting, 3 unknown, 2 active not recruiting. 8 Phase 2, 7 Phase 4, 6 Phase 3, 4 Not applicable, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 6, Recruiting 2 |
| Phase 4 | 7 | Completed 4, Recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 3 | 6 | Completed 4, Active not recruiting 2 |
| Not applicable | 4 | Completed 4 |
| Phase 1 | 2 | Completed 2 |
Follow Diphosphonates: new trials by email Literature Review of Diphosphonates trials Research Report on Diphosphonates
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Zanzalintinib for Metastatic Clear Cell Renal Cell Carcinoma With Bone Metastases Zanzalintinib, Investigator Choice of Bone Strengthening Agents (BSA), Non-Investigational Radiation Therapy (RT) - Clear Cell Renal Cell Cancer (ccRCC), Clear Cell Renal Carcinoma | Phase 2 | Recruiting | Kelly Fitzgerald, MD | 20 | 2026-06-10 | 2026-07-27 |
| Effect of Local Subperiosteal Zoledronic Acid Injection on the Survival of Orthodontic Miniscrews Zoledronic Acid, Normal saline (0.9% sodium chloride) - Orthodontic Appliance Complication | Not applicable | Completed | Latakia University | 68 | 2024-12-01 | 2026-04-22 |
| The Effect of Long-term Use of Bisphosphonates on Femur Morphology Bisphosphonates, Control - Osteoporosis, Knee Osteoarthristis | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 140 | 2024-06-01 | 2024-10-01 | |
| Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta Romosozumab, Bisphosphonate - Osteogenesis Imperfecta | Phase 3 | Active not recruiting | Amgen | 111 | 2024-04-22 | 2026-05-27 |
| Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfecta Bisphosphonate, Setrusumab - Osteogenesis Imperfecta | Phase 3 | Active not recruiting | Ultragenyx Pharmaceutical Inc | 69 | 2023-06-14 | 2026-10-20 |
| Bone, Exercise, Alendronate, and Caloric Restriction Bisphosphonate, Resistance Training/Bone-Loading Exercise, Placebo - Bone Loss | Phase 4 | Recruiting | Wake Forest University Health Sciences | 900 | 2023-06-08 | 2026-06-09 |
| Prospective Research for Elderly (≥65 Years Old) Early Breast Cancer Patients operation, Bisphosphonate - Breast Cancer Female | Unknown | Peking Union Medical College Hospital | 1000 | 2022-04-01 | 2023-01-11 | |
| Post-fracture Medication and Mortality Anti-osteoporosis medications - Osteoporosis, Osteoporosis Fracture | Completed | National Cheng-Kung University Hospital | 216155 | 2020-11-01 | 2023-04-04 | |
| Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures Radiofrequency ablation of the medial branch nerves, Non-steroidal anti-inflammatory drugs, Bisphosphonates - Vertebral Compression Fracture, Facet Joint Pain | Phase 4 | Withdrawn | University of California, Davis | 2019-04-10 | 2025-07-16 | |
| Effect of Consumption of Supplements and Enriched Olive Paste on Bone Metabolism Indices Functional olive paste, Calciovitmag (CDCaMg), Phosporovitmag (PDCaMg) - Osteopenia or Osteoporosis | Not applicable | Completed | University of the Aegean | 115 | 2019-03-15 | 2023-11-18 |
| Dental Care and Initiation of Anti-osteoporotic Therapy biphosphonates, Dental care - Dental Condition, Osteoporosis | Completed | Centre Hospitalier Universitaire de Nice | 338 | 2019-01-03 | 2023-02-09 | |
| Examination of Efficacy and Safety of Other Anti-Resorption Drugs After 2-year-Denosumab Therapy in Japanese Osteoporosis Patients SERM "Viviant®Tablet 20mg" and ELD "Edirol®Tablet 0.75ug", Bisphosphonates and ELD "Edirol®Tablet 0.75ug", ELD "Edirol®Tablet 0.75ug" - Osteoporosis | Phase 2 | Recruiting | Shinshu University | 90 | 2018-11-24 | 2021-09-21 |
| A Prospective Observational Study About Adjuvant or Neoadjuvant Chemotherapy Related Adverse Effects in Postmenopausal Breast Cancer Patients Bisphosphonates - Breast Cancer | Unknown | Sun Yat-sen University | 2000 | 2018-06-15 | 2018-06-20 | |
| Do Bisphosphonates Alter the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfecta? Risedronate Sodium, Calcichew tablets - Osteogenesis Imperfecta | Phase 2 | Completed | Sheffield Children's NHS Foundation Trust | 13 | 2017-04-01 | 2018-09-07 |
| Effectiveness or Orthopedic Intervention in Osteoporosis Management After a Fracture of the Hip With Cost-Benefit Analysis Letter Group, Intervention Group - Osteoporotic Fracture | Not applicable | Completed | Shaare Zedek Medical Center | 200 | 2017-02-21 | 2019-04-05 |
| Exome Sequencing for Atypical Femoral Fractures Bisphosphonate - Atypical Femoral Fractures, Osteoporosis | Completed | Washington University School of Medicine | 38 | 2016-04-01 | 2018-12-31 | |
| Breast Cancer Women on Aromatase Inhibitors Treatment bisphosphonate - Osteoporosis, Osteoporosis Fracture | Phase 4 | Unknown | Parc de Salut Mar | 1000 | 2016-01-01 | 2019-01-28 |
| Prevention of Bone Loss After Acute SCI by Zoledronic Acid Zoledronic acid, Placebo - Spinal Cord Injury, Acute Spinal Cord Injury | Phase 2 | Completed | Northwestern University | 60 | 2015-02-01 | 2025-12-02 |
| Bisphosphonates Effects On Alveolar Bone Among Osteoporotic Women Bisphosphonates - Osteoporosis | Completed | Damascus University | 60 | 2014-04-01 | 2015-09-29 | |
| The Effect of Alendronate on the Immune Response to Hepatitis B Vaccine in Healthy Adults Alendronate, Hepatitis B Vaccine, Placebo - Hepatitis B | Phase 1 | Completed | Massachusetts General Hospital | 28 | 2014-04-01 | 2016-10-21 |
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Osteoporosis (17) · Breast Neoplasms (5) · Bone Diseases, Metabolic (4) · Neoplasm Metastasis (4) · Osteogenesis Imperfecta (4) · Osteoporotic Fractures (3) · Multiple Myeloma (2) · Arthralgia (1) · Bone Diseases (1) · Bone Resorption (1) · Carcinoma, Renal Cell (1) · Central Nervous System Diseases (1) · Clear-cell metastatic renal cell carcinoma (1) · Fractures, Spontaneous (1) · Fractures, Stress (1)
Amgen (3) · Pfizer (2) · Centre Hospitalier Universitaire de Nice (1) · Children's Cancer Hospital Egypt 57357 (1) · Damascus University (1) · Eulji University Hospital (1) · Federal University of Minas Gerais (1) · Karolinska Institutet (1) · Kelly Fitzgerald, MD (1) · Latakia University (1) · Luca Sangiorgi (1) · Massachusetts General Hospital (1) · Montefiore Medical Center (1) · National Cheng-Kung University Hospital (1) · National Defense Medical Center, Taiwan (1)
United States (11) · China (5) · France (4) · Canada (3) · Italy (3) · Poland (3) · Spain (3) · Belgium (2) · Brazil (2) · Germany (2) · Japan (2) · Syria (2) · Taiwan (2) · United Kingdom (2) · Australia (1)
Alan W Craft, Prof Sir MD (1) · Chi Chiu Mok, MD, FRCP (1) · Chih-Hsing Wu, MD (1) · David Copenhaver, MD (1) · Fernando O Costa, PhD (1) · Gershon Zinger, MD MS (1) · Hee-Jeong Choi, MD, PhD (1) · Imad Barngkgei, DDS MSc (1) · Iyad Al-Haffar, DDS MSc PhD (1) · Karen E Yeates, Dr (1) · Kelly Fitzgerald, MD (1)
PMID 42470570, PMID 16637733, PMID 20152674, PMID 22797188, PMID 25761434, PMID 26271204, PMID 26327926, PMID 26572609, PMID 30334093, PMID 30477773, PMID 31127467, PMID 31553693, PMID 33409700, PMID 34180292, PMID 34278611, PMID 35427190, PMID 38492035, PMID 38524902, PMID 39796745
2023 (2), 2008 (1), R01AG074979 (1)