11 completed, 4 terminated, 3 recruiting, 3 unknown. 25 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 25 | Completed 11, Terminated 4, Recruiting 3, Unknown 3, Active not recruiting 2, Suspended 1, Withdrawn 1 |
| Phase 2 | 6 | Unknown 3, Completed 1, Suspended 1, Terminated 1 |
Follow Osteosarcoma: new trials by email Literature Review of Osteosarcoma trials Research Report on Osteosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fight Osteosarcoma Through European Research Evolving Study Platform From Diagnosis to Relapse Experimental group : Cabometyx ® 40mg/m2/day (Max: 60mg/day) , Treatment schedule : Daily**, day 1-28 during 4 weeks (ie. 1 cycle) during 12 cycles - Osteosarcoma, Pediatric Osteosarcoma | Phase 3 | Recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 530 | 2026-10-07 | 2026-10-26 |
| Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - CIC-Rearranged Sarcoma, Metastatic Ewing Sarcoma | Phase 2 / Phase 3 | Terminated | Children's Oncology Group | 2 | 2025-11-10 | 2026-10-05 |
| Study of HS-20093 Versus Gemcitabine in Combination With Docetaxel in Treatment of Osteosarcoma After Previous Second-line Treatment Failure HS-20093, Gemcitabine combined with docetaxel - Osteosarcoma | Phase 3 | Completed | Hansoh BioMedical R&D Company | 122 | 2025-04-25 | 2026-10-19 |
| Use of GnRHa During Chemotherapy for Fertility Protection Triptorelin Embonate, Sodium Chloride solution 0.9% - Breast Cancer Female, Acute Leukemia | Phase 3 | Recruiting | Kenny Rodriguez-Wallberg | 500 | 2023-03-31 | 2023-10-27 |
| A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma Bone Scan, Cabozantinib S-malate, Cisplatin - High Grade Osteosarcoma, Localized Osteosarcoma | Phase 2 / Phase 3 | Suspended | National Cancer Institute (NCI) | 1122 | 2023-03-03 | 2026-10-27 |
| Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma Biospecimen Collection, Computed Tomography, Questionnaire Administration - Metastatic Malignant Neoplasm in the Lung, Metastatic Osteosarcoma | Phase 3 | Recruiting | Children's Oncology Group | 62 | 2022-04-01 | 2026-08-25 |
| Neoadjuvant Combination of Doxorubicin, Cisplatin and Methotrexate in Patients Aged 24-40 Years With Primary Bone Tumors Doxorubicin, Cisplatin, Methotrexate, Doxorubicin, Cisplatin - Osteosarcoma, Neoplasms, Connective Tissue | Phase 2 / Phase 3 | Unknown | Blokhin's Russian Cancer Research Center | 50 | 2022-01-10 | 2024-04-01 |
| Perioperative Use of Tranexamic (TXA) in Bone Tumor Surgery Will Change in Blood Loss and Transfusion Requirements. Tranexamic acid injection, Saline - Ewing Sarcoma of Bone, Osteosarcoma | Phase 3 | Completed | Children's Cancer Hospital Egypt 57357 | 48 | 2021-08-02 | 2024-02-07 |
| A Trial For Participants With Ewing's Sarcoma Treated With Vigil in Combination With Irinotecan and Temozolomide Vigil, Irinotecan, Temozolomide - Ewing Sarcoma, Ewing Family of Tumors | Phase 3 | Terminated | Gradalis, Inc. | 32 | 2018-08-21 | 2023-04-26 |
| Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer Triptorelin (GnRHa) + Chemotherapy - Cancer, Toxicity Due to Chemotherapy | Phase 2 / Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 11 | 2016-11-23 | 2019-12-17 |
| Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy apatinib - Osteosarcoma, Metastasis | Phase 2 / Phase 3 | Completed | GUO WEI | 37 | 2016-03-01 | 2018-04-23 |
| Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Cyclophosphamide, Doxorubicin, Doxorubicin Hydrochloride - Metastatic Ewing Sarcoma, Metastatic Malignant Neoplasm in the Bone | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 312 | 2014-12-12 | 2026-11-13 |
| Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer filgrastim - Childhood Choroid Plexus Tumor, Childhood Medulloblastoma | Phase 3 | Terminated | Barbara Ann Karmanos Cancer Institute | 23 | 2013-08-01 | 2020-10-29 |
| Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients External Beam Radiotherapy - Ewing's Sarcoma | Phase 3 | Withdrawn | Children's Cancer Hospital Egypt 57357 | 2012-09-01 | 2016-01-12 | |
| Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma High Dose Methotrexate - Osteosarcoma | Phase 3 | Completed | The Hospital for Sick Children | 6 | 2010-10-01 | 2021-10-28 |
| Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer cyproheptadine hydrochloride, placebo - Cancer | Phase 3 | Terminated | University of South Florida | 22 | 2010-06-01 | 2015-07-02 |
| Study in Localized and Disseminated Ewing Sarcoma Zoledronic acid, Busulfan, Treosulfan - Ewing's Sarcoma | Phase 3 | Completed | University Hospital Muenster | 907 | 2009-10-01 | 2019-10-22 |
| Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma Standard treatment (as per protocol ISG SSG III), Intensified chemotherapy - Ewing's Sarcoma | Phase 3 | Completed | Italian Sarcoma Group | 278 | 2009-01-22 | 2022-09-19 |
| Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy sodium thiosulfate, examination - Brain Tumor, Central Nervous System Tumor | Phase 3 | Completed | Children's Oncology Group | 131 | 2008-06-23 | 2023-11-09 |
| Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma Zoledronic acid, Standard chemotherapy - Osteosarcoma | Phase 2 / Phase 3 | Unknown | Tata Memorial Hospital | 60 | 2008-05-01 | 2011-06-23 |
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Sarcoma, Ewing (9) · Sarcoma (8) · Medulloblastoma (4) · Neoplasms (4) · Choroid Plexus Neoplasms (3) · Neuroblastoma (3) · Neuroectodermal Tumors, Primitive, Peripheral (3) · Testicular Neoplasms (3) · Astrocytoma (2) · Bone Neoplasms (2) · Brain Neoplasms (2) · Chondrosarcoma (2) · Glioblastoma (2) · Hepatoblastoma (2)
Neoplasms by Histologic Type (24) · Neoplasms, Bone Tissue (24) · Neoplasms, Connective Tissue (23) · Neoplasms, Connective and Soft Tissue (23) · Neoplasms (21) · Sarcoma (17) · Pathological Conditions, Signs and Symptoms (7) · Pathologic Processes (6) · Neoplasms by Site (5) · Neoplasms, Germ Cell and Embryonal (5) · Neoplasms, Glandular and Epithelial (5) · Neoplasms, Nerve Tissue (5) · Neuroectodermal Tumors (5) · Brain Diseases (4)
Doxorubicin (9) · Ifosfamide (6) · Methotrexate (6) · Etoposide (5) · Cisplatin (4) · Cyclophosphamide (3) · Vincristine (3) · Zoledronic Acid (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · Busulfan (2) · Irinotecan (2) · Magnetic Resonance Spectroscopy (2) · Platinum (2) · Radiation (2) · Specimen Handling (2)
Children's Oncology Group (4) · National Cancer Institute (NCI) (3) · Children's Cancer Hospital Egypt 57357 (2) · Gustave Roussy, Cancer Campus, Grand Paris (2) · Assistance Publique - Hôpitaux de Paris (1) · Barbara Ann Karmanos Cancer Institute (1) · Blokhin's Russian Cancer Research Center (1) · GUO WEI (1) · Gradalis, Inc. (1) · Hansoh BioMedical R&D Company (1) · INSYS Therapeutics Inc (1) · Italian Sarcoma Group (1) · Kenny Rodriguez-Wallberg (1) · Tata Memorial Hospital (1) · The Hospital for Sick Children (1)
United States (11) · Canada (6) · Australia (4) · France (4) · New Zealand (3) · Puerto Rico (3) · China (2) · Egypt (2) · Italy (2) · Sweden (2) · Denmark (1) · Finland (1) · Germany (1) · India (1) · Netherlands (1)
Abha Gupta, MD (1) · Alan W Craft, Prof Sir MD (1) · Beniamin Bokhyan, PhD (1) · Bhuvana A Setty (1) · Chantal Kalifa, MD (1) · David R. Freyer, DO, MS (1) · Jeffrey P. Krischer, PhD (1) · John J Doski (1) · John Nemunaitis, MD (1) · Larry Dillaha, MD (1) · Laurence Brugieres, MD (1) · Manish Agarwal, M.S(Orth) (1)
PMID 31401903, PMID 17267204, PMID 22480131, PMID 25421877, PMID 26271204, PMID 27020837, PMID 27324280, PMID 27569442, PMID 27914822, PMID 28619014, PMID 29791011, PMID 31553693, PMID 35246418, PMID 35427190, PMID 36669140, PMID 38070906, PMID 38524902, PMID 39796745, PMID 39833645, PMID 42208702
U10CA180886 (5), U10CA098543 (2), 2004 (1), 2008 (1), 2015 (1), 2023 (1), P30CA022453 (1), U10CA081920 (1)