191 completed, 54 recruiting, 42 active not recruiting, 30 terminated. 134 Not applicable, 97 Phase 2, 33 Phase 1, 30 Phase 3, 8 Early Phase 1.
Follow Breast Carcinoma In Situ: new trials by email Literature Review of Breast Carcinoma In Situ trials Research Report on Breast Carcinoma In Situ
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of Biosignature Classification of DCIS for RadioTherapy Benefit Post Lumpectomy (ABCD RT) Radiation Therapy, Standard of Care Radiation Therapy, No Intervention - Breast Cancer | Phase 3 | Not yet recruiting | NRG Oncology | 5270 | 2027-01-30 | 2026-09-30 |
| Evaluation of Novel Iron-based Lymphatic Mapping Agent, Magtrace, for Delayed Sentinel Lymph Node Biopsy (SLNB) in Ductal Carcinoma In-Situ (DCIS) Magtrace - Ductal Carcinoma in Situ | Phase 2 | Suspended | University of Florida | 30 | 2026-10-01 | 2026-09-11 |
| CAN1012 in Pre-Malignant DCIS and LCIS CAN1012 - Ductal Carcinoma in Situ, Lobular Carcinoma in Situ | Phase 1 | Recruiting | Providence Health & Services | 24 | 2026-09-16 | 2026-09-24 |
| A Navigation Program to Improve Survivorship Support Service Participation Among Non-metastatic Breast Cancer Survivors Best Practice, Patient Navigation, Referral - Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 330 | 2026-09-01 | 2026-08-14 |
| HISMAR: Intraoperative Margin Assessment Using the Histolog® Scanner to Reduce Reoperation in Breast-Conserving Surgery Histolog® Scanner - Breast Cancer, Ductal Carcinoma In Situ | Not applicable | Not yet recruiting | Hôpital du Valais | 228 | 2026-09-01 | 2026-04-14 |
| Omission of Adjuvant Radiotherapy in Young Low-Risk Ductal Carcinoma In Situ Following Breast-Conserving Surgery Observation, Endocrine Therapy (Optional) - Ductal Carcinoma In Situ, DCIS | Phase 2 | Recruiting | Fudan University | 234 | 2026-09-01 | 2026-08-13 |
| Personalized Prone Immobilization for Accelerated Partial Breast Radiotherapy VENUS SHELL™ immobilization device - Invasive Breast Cancer Early Stages, Ductal Carcinoma In Situ, DCIS | Not applicable | Recruiting | HeroSupport SA | 30 | 2026-07-02 | 2026-09-23 |
| Omission of Adjuvant Radiotherapy in Low- and Intermediate-Risk Ductal Carcinoma In Situ After Breast-Conserving Surgery Adjuvant Radiotherapy, tamoxifen - Ductal Carcinoma In Situ, DCIS | Phase 3 | Recruiting | Fudan University | 636 | 2026-07-01 | 2026-08-13 |
| Areola Preservation in NSM With Nipple Involvement Areola-Preserving Nipple-Sparing Mastectomy with Immediate Nipple Reconstruction - Breast Cancer, Ductal Carcinoma In Situ, DCIS | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 40 | 2026-05-01 | 2026-04-22 |
| A Dietary Supplement (Resistant Potato Starch) for Reducing Musculoskeletal Symptoms in Individuals Planning to Receive Aromatase Inhibitor Therapy, AIMSS-RPS Trial Starch, Potato - Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | Phase 2 | Recruiting | University of Michigan Rogel Cancer Center | 20 | 2026-04-22 | 2026-04-24 |
| Breast Tumour Size Measurement by Field Cycling Imaging Field-Cycling Imaging research scan, 3T MRI research scan - Breast Cancer, Ductal Carcinoma In Situ | Not yet recruiting | University of Aberdeen | 12 | 2026-04-01 | 2026-03-25 | |
| Multimodal Imaging With FAPI-PET/MRI in Breast Carcinoma-In-Situ for Detection of Occult Invasive Cancer [68Ga]Ga-FAPI-46 - Carcinoma, Intraductal, Noninfiltrating | Phase 2 | Recruiting | Universität Münster | 30 | 2026-02-20 | 2026-06-03 |
| A Novel Fluorescent Ductal Needle for Localization and Sampling of Micro Lesions in Breast Ducts novel fluorescent localization marker needle, conventional localization marker needle - Mammary Tumor, Nipple Discharge | Not applicable | Active not recruiting | The Fourth Affiliated Hospital of China Medical University | 300 | 2026-01-01 | 2026-10-13 |
| Avoiding Surgery in Estrogen Receptor Positive Atypical Ductal Hyperplasia and In-situ Carcinoma Treated With Endocrine Treatment Trial Avoiding surgery - Ductal Carcinoma in Situ of the Breast | Not applicable | Not yet recruiting | Jeong Eon Lee | 340 | 2025-12-01 | 2025-11-24 |
| Novel Cavity Marking Technique in Breast Cancer Patients Undergoing Breast Conservation Surgery With Oncoplastic Reconstruction for the Delivery of Adjuvant Radiotherapy and Accuracy of Recommended Re-excisions Novel cavity marking technique - Ductal Carcinoma in Situ, Breast Cancer | Not applicable | Recruiting | University of Florida | 50 | 2025-10-27 | 2026-09-09 |
| A Prospective CohorT Study of HandX - Assisted ENdoscopic MAstectomy: Feasibility and Safety (ATHENA I Study) Endoscopic nipple sparing mastectomy, HandX endoscopic instrument - Breast Cancer, BRCA 1 Gene Mutation | Not applicable | Recruiting | Vasileios Kalles | 15 | 2025-09-09 | 2025-12-18 |
| Pilot Trial of Preop Partial Radiation in Breast Cancer Patients Radiation: Accelerated Partial Breast Irradiation (APBI) - Early-stage Breast Cancer, Breast Carcinoma | Phase 1 | Suspended | Rutgers, The State University of New Jersey | 98 | 2025-09-02 | 2025-11-14 |
| A Study of Disappearing Markers for Daily Radiation Treatment Delivery for Breast Cancer Patients. Magic Ink - Ductal Carcinoma in Situ, Stage I Breast Cancer | Not applicable | Recruiting | Barbara Ann Karmanos Cancer Institute | 30 | 2025-08-18 | 2025-09-18 |
| Human-AI Collaborative INSIGHT Diagnostic Workflow for in Breast Cancer With Extensive Intraductal Component INvasion Screening with Intelligent Guidance for Histopathology Triage (INSIGHT) Workflow - Artificial Intelligence (AI) in Diagnosis | Not applicable | Not yet recruiting | Sun Yat-sen University | 480 | 2025-08-01 | 2025-07-11 |
| Low Dose Tamoxifen With or Without Omega-3 Fatty Acids for Breast Cancer Risk Reduction Biospecimen Collection, Mammography, Omega-3-Acid Ethyl Esters - Breast Atypical Hyperplasia, Breast Carcinoma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 66 | 2025-07-28 | 2026-08-04 |
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Carcinoma, Intraductal, Noninfiltrating (281) · Breast Neoplasms (265) · Carcinoma, Ductal, Breast (26) · Carcinoma, Lobular (22) · Hot Flashes (11) · Breast Neoplasms, Male (9) · Fatigue (7) · Pain (7) · Depression (6) · Neoplasms (6) · Precancerous Conditions (6) · Triple Negative Breast Neoplasms (6) · Inflammatory Breast Neoplasms (5) · Lymphedema (4)
Neoplasms by Histologic Type (379) · Neoplasms, Glandular and Epithelial (379) · Carcinoma in Situ (377) · Carcinoma (376) · Neoplasms (373) · Neoplasms by Site (316) · Skin Diseases (316) · Skin and Connective Tissue Diseases (316) · Breast Diseases (314) · Adenocarcinoma (291) · Neoplasms, Ductal, Lobular, and Medullary (290) · Breast Neoplasms (51) · Pathological Conditions, Signs and Symptoms (35) · Carcinoma, Ductal (26)
Tamoxifen (31) · Radiotherapy (18) · Anastrozole (13) · Chemotherapy, Adjuvant (12) · Letrozole (12) · Specimen Handling (12) · Biopsy (9) · Early Intervention, Educational (9) · Neoadjuvant Therapy (9) · Immunohistochemistry (8) · Magnetic Resonance Spectroscopy (7) · Mastectomy, Segmental (7) · Methods (7) · Practice Guidelines as Topic (7) · Radiation (7)
Mayo Clinic (17) · National Cancer Institute (NCI) (16) · Ohio State University Comprehensive Cancer Center (14) · M.D. Anderson Cancer Center (11) · Alliance for Clinical Trials in Oncology (9) · Wake Forest University Health Sciences (8) · City of Hope Medical Center (7) · Dana-Farber Cancer Institute (7) · Northwestern University (7) · Case Comprehensive Cancer Center (6) · Jonsson Comprehensive Cancer Center (6) · Rutgers, The State University of New Jersey (6) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (6) · OHSU Knight Cancer Institute (5) · Roswell Park Cancer Institute (5)
United States (280) · Canada (23) · France (13) · Italy (11) · United Kingdom (11) · Puerto Rico (9) · Switzerland (9) · China (8) · South Korea (8) · Australia (6) · Germany (6) · Belgium (4) · Denmark (4) · Ireland (4) · Israel (4)
Vered Stearns, MD (5) · Nicole Simone, MD (4) · Laura Esserman, MD, MBA (3) · Anna Wu (2) · Barbara L. Smith, MD, PhD (2) · Benjamin D Smith (2) · Bruce Haffty, MD (2) · David L Kleinberg, MD (2) · Douglas W. Arthur, MD (2) · Eileen Rakovitch, M.D. (2) · Elinor Sawyer, MD (2) · Ercole Cavalieri, DSc (2) · Jackilen Shannon, PhD (2) · Lisa Spiguel, MD (2) · Michelle Naughton, PhD (2)
PMID 23984897, PMID 34469056, PMID 14962527, PMID 16382061, PMID 16461781, PMID 16730270, PMID 17200148, PMID 17234359, PMID 17301074, PMID 17392300, PMID 17492927, PMID 17679725, PMID 17912636, PMID 17998546, PMID 18065731, PMID 18083065, PMID 18097749, PMID 18279765, PMID 18313521, PMID 18332471, PMID 18364505, PMID 18786783, PMID 18809612, PMID 18979140, PMID 18981464, PMID 19031925, PMID 19096768, PMID 19224552, PMID 19231103, PMID 19243946, PMID 19474112, PMID 19528136, PMID 19692688, PMID 19728082, PMID 19826126, PMID 19896789, PMID 20144231, PMID 20385495, PMID 20501712, PMID 20508186, PMID 20562526, PMID 20800381, PMID 20846604, PMID 20888137, PMID 21046229, PMID 21321298, PMID 21335417, PMID 21533657, PMID 21635709, PMID 21665139
P30CA016672 (7), P30CA060553 (7), P30CA006973 (5), P30CA012197 (5), P30CA033572 (5), N01CN00034 (4), P30CA015704 (4), P30CA072720 (4), P30CA014089 (3), P30CA015083 (3), P30CA036727 (3), P30CA043703 (3), P30CA069533 (3), U10CA037429 (3), UG1CA242632 (3)