102 completed, 55 recruiting, 26 active not recruiting, 23 terminated. 111 Phase 2, 104 Phase 1, 22 Not applicable, 9 Phase 3, 2 Early Phase 1.
Follow Sarcoma, Ewing: new trials by email Literature Review of Sarcoma, Ewing trials Research Report on Sarcoma, Ewing
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-08-26 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-08-26 |
| A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat Archive Sample Retrieval, Biospecimen Collection, pH Low Insertion Peptide-exatecan Conjugate CBX-12 - Recurrent Childhood Ewing Sarcoma, Recurrent Childhood Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 79 | 2027-05-07 | 2026-09-22 |
| RAPID: Phase 2 Platform Trial Of Promising Drugs For AYA Patients With R/R Ewing Sarcoma & DSRCT LX-101 - Ewing Sarcoma | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 120 | 2027-02-01 | 2026-08-24 |
| EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT EWSR1 immunotherapy, Pembrolizumab - Ewing Sarcoma, Desmoplastic Small Round Cell Tumor | Phase 1 | Not yet recruiting | Rabi Hanna | 24 | 2026-10-01 | 2026-09-17 |
| my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults my.naviGATE Digital Tool - Sarcoma, Osteosarcoma | Not applicable | Not yet recruiting | Dana-Farber Cancer Institute | 143 | 2026-08-20 | 2026-04-08 |
| Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma Proton Therapy (Adaptive) - Pediatric Solid Tumors, Rhabdomyosarcoma | Not applicable | Recruiting | St. Jude Children's Research Hospital | 100 | 2026-08-20 | 2026-08-21 |
| Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma Eflornithine, Topotecan, Cyclophosphamide - Osteosarcoma, Ewing Sarcoma | Phase 2 | Recruiting | Milton S. Hershey Medical Center | 406 | 2026-06-05 | 2026-10-06 |
| Neoadjuvant Radiotherapy and Surgery for High-Risk Localized Ewing Sarcoma Ewing Sarcoma, Bone Neoplasms | Not yet recruiting | Peking University People's Hospital | 55 | 2026-06-01 | 2026-06-02 | |
| Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas Eflornithine (DFMO), AMXT 1501 Dicaprate - Atypical Teratoid/Rhabdoid Tumor, Embryonal Tumor With Multilayered Rosettes | Phase 1 / Phase 2 | Recruiting | Milton S. Hershey Medical Center | 265 | 2026-05-13 | 2026-09-03 |
| Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors Methionine-Reduced Diet - Adenocarcinoma, Basal Cell Carcinoma | Early Phase 1 | Recruiting | University of California, Irvine | 25 | 2026-05-01 | 2026-07-31 |
| Identification of Circulating Biomarkers Associated With Extracellular Vesicles in Sarcomas one blood sample, 3 blood samples - Sarcoma, Ewing | Recruiting | Istituto Ortopedico Rizzoli | 16 | 2026-04-15 | 2026-07-06 | |
| Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS) Xaluritamig - Ewing Sarcoma | Phase 1 | Recruiting | Amgen | 50 | 2026-04-08 | 2026-09-25 |
| Liposomal Irinotecan, Vincristine, Temozolomide, and Anlotinib for R/R Pediatric Solid Tumors Liposomal Irinotecan, Vincristine, Temozolomide, and Optional Anlotinib - Relapsed or Refractory Pediatric Malignant Solid Tumors (Including Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma, Osteosarcoma) | Phase 2 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 33 | 2026-03-01 | 2026-03-03 |
| Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors Miltenyi CliniMACS Prodigy ® system, Zoledronic acid - Neuroblastoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University of Florida | 27 | 2026-02-11 | 2026-06-30 |
| Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes Vincristine, Doxorubicin, Cyclophosphamide - Metastatic Ewing Sarcoma | Phase 1 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 15 | 2026-02-05 | 2026-09-25 |
| Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE) Selective Antigen Specific dTβRII-expressing T cells combined with B7-H3 CAR T cells - Rhabdomyosarcoma, Ewing Sarcoma | Phase 1 | Recruiting | Children's National Research Institute | 18 | 2026-01-27 | 2026-08-13 |
| Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas Fludarabine, Cyclophosphamide, B7-H3-CAR T Cells - Sarcoma, Childhood Osteosarcoma | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 42 | 2026-01-21 | 2026-02-09 |
| Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial Biospecimen Collection, Chemotherapy, Computed Tomography - Ewing Sarcoma, Round Cell Sarcoma With EWSR1-non-ETS Fusion | Not applicable | Recruiting | Mayo Clinic | 170 | 2025-12-05 | 2026-10-06 |
| A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies ST-01156 - Advanced Solid Tumors, Ewing Sarcoma | Phase 1 | Recruiting | SEED Therapeutics, Inc. | 171 | 2025-12-01 | 2026-06-02 |
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Osteosarcoma (114) · Rhabdomyosarcoma (106) · Sarcoma (104) · Neuroblastoma (79) · Wilms Tumor (50) · Medulloblastoma (30) · Rhabdoid Tumor (29) · Hepatoblastoma (28) · Neoplasms (28) · Bone Neoplasms (25) · Neuroectodermal Tumors, Primitive, Peripheral (25) · Glioma (20) · Ependymoma (19) · Recurrence (19)
Neoplasms by Histologic Type (243) · Neoplasms, Bone Tissue (243) · Neoplasms, Connective Tissue (243) · Neoplasms, Connective and Soft Tissue (242) · Neoplasms (216) · Sarcoma (140) · Osteosarcoma (130) · Neoplasms, Muscle Tissue (114) · Myosarcoma (109) · Neoplasms, Nerve Tissue (106) · Neoplasms, Glandular and Epithelial (104) · Neoplasms by Site (102) · Neuroectodermal Tumors (96) · Neoplasms, Neuroepithelial (95) · Neoplasms, Germ Cell and Embryonal (90)
Cyclophosphamide (25) · Temozolomide (22) · Irinotecan (18) · Vincristine (18) · Doxorubicin (13) · Etoposide (10) · Melphalan (10) · Topotecan (10) · Busulfan (8) · Ifosfamide (8) · Granulocyte Colony-Stimulating Factor (7) · Magnetic Resonance Spectroscopy (7) · Specimen Handling (7) · cabozantinib (7) · Filgrastim (6)
National Cancer Institute (NCI) (31) · St. Jude Children's Research Hospital (12) · Peking University People's Hospital (11) · Istituto Ortopedico Rizzoli (8) · Children's Oncology Group (6) · Dana-Farber Cancer Institute (6) · Emory University (5) · Gradalis, Inc. (5) · Eli Lilly and Company (4) · Grupo Espanol de Investigacion en Sarcomas (4) · M.D. Anderson Cancer Center (4) · Memorial Sloan Kettering Cancer Center (4) · Children's National Research Institute (3) · Gustave Roussy, Cancer Campus, Grand Paris (3) · Italian Sarcoma Group (3)
United States (163) · Italy (27) · France (24) · China (22) · Spain (17) · Canada (16) · United Kingdom (16) · Australia (13) · Germany (12) · Puerto Rico (10) · Netherlands (6) · Poland (5) · Belgium (4) · Egypt (4) · South Korea (3)
AeRang Kim, MD, PhD (4) · Crystal L Mackall, M.D. (4) · John Nemunaitis, MD (4) · Brigitte C Widemann, M.D. (3) · Matteo Trucco, MD (3) · Alessandra Longhi, MD (2) · Alok Kothari, M.D. (2) · Anna Raciborska, Prof. (2) · Antonio Casado (2) · Claudia Valverde (2) · David Shulman, MD (2)
PMID 31401903, PMID 22682017, PMID 31553693, PMID 18391430, PMID 18676758, PMID 19451433, PMID 20036194, PMID 21896345, PMID 22088484, PMID 22186789, PMID 23071222, PMID 23382028, PMID 23450030, PMID 24089446, PMID 24711551, PMID 25374341, PMID 25452614, PMID 25838377, PMID 25917459, PMID 26154941, PMID 26271204, PMID 26331920, PMID 27109631, PMID 27362300, PMID 27567955, PMID 27932229, PMID 27974040, PMID 28295221, PMID 28494338, PMID 28735378, PMID 28934351, PMID 29033609, PMID 29544202, PMID 29558948, PMID 29931504, PMID 29977059, PMID 30410720, PMID 30477937, PMID 31013172, PMID 31838007, PMID 31876107, PMID 31902458, PMID 31987969, PMID 32078813, PMID 32169872, PMID 32192573, PMID 32471029, PMID 32554315, PMID 32733795, PMID 33203665
U10CA180886 (12), 2023 (5), U10CA098543 (5), UM1CA228823 (3), 2016 (2), 2008 (1), 2009 (1), 2015 (1), 2017 (1), 2018 (1), 2019 (1), P01CA225618 (1), P30CA060553 (1), R01CA276684 (1), R21CA159547 (1)