1769 completed, 604 recruiting, 443 unknown, 393 terminated. 1402 Phase 2, 898 Phase 1, 591 Not applicable, 313 Phase 3, 97 Phase 4.
Follow this condition Literature Review of Neoplasms, Connective and Soft Tissue trials Research Report on Neoplasms, Connective and Soft Tissue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neoadjuvant Pimicotinib Combined With Surgery Versus Upfront Surgery for Diffuse Tenosynovial Giant Cell Tumor Pimicotinib, Tumor resection surgery - Tenosynovial Giant Cell Tumor, Diffuse | Phase 2 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 84 | 2027-10-01 | 2026-07-16 |
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-08-26 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-08-26 |
| A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat Archive Sample Retrieval, Biospecimen Collection, pH Low Insertion Peptide-exatecan Conjugate CBX-12 - Recurrent Childhood Ewing Sarcoma, Recurrent Childhood Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 79 | 2027-05-07 | 2026-09-22 |
| Information-providing Chatbot ASCC (sarcoma-specific AI chatbot), Routine Clinical Care - Sarcoma | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 78 | 2027-04-01 | 2026-04-01 |
| Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors Aldesleukin, Biospecimen Collection, Chest Radiography - Locally Advanced Gastrointestinal Stromal Tumor, Metastatic Gastrointestinal Stromal Tumor | Phase 2 | Not yet recruiting | Joal Beane | 59 | 2027-02-15 | 2026-10-13 |
| Doxorubicin With or Without DT-7012 in Advanced Soft Tissue Sarcoma DT-7012, Doxorubicin - Undifferentiated Pleomorphic Sarcoma (UPS), Dedifferentiated Liposarcoma (DDLPS) | Phase 2 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 80 | 2027-02-01 | 2026-09-15 |
| RAPID: Phase 2 Platform Trial Of Promising Drugs For AYA Patients With R/R Ewing Sarcoma & DSRCT LX-101 - Ewing Sarcoma | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 120 | 2027-02-01 | 2026-08-24 |
| A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). ST316 IV - Familial Adenomatous Polyposis (FAP) | Phase 1 | Not yet recruiting | Sapience Therapeutics | 40 | 2027-01-04 | 2026-08-12 |
| Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor avutometinib capsule + defactinib tablet - MPNST (Malignant Peripheral Nerve Sheath Tumor) | Phase 2 | Not yet recruiting | Girish Dhall, MD | 23 | 2027-01-01 | 2026-08-04 |
| Bone Arches: Performance of Pseudo-scanner Sequences in Segmenting the Extent of the Tumour and in Planning Surgical Resection Using the CT Scan as a Reference Whole body MRI - Sarcoma | Not applicable | Not yet recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 122 | 2027-01-01 | 2026-04-29 |
| Hyperpolarized MRI for GIST on Imatinib Hyperpolarized 13C-MRI - Imatinib Therapy Response, Gastrointestinal Stromal Tumor (GIST) | Not yet recruiting | Chang Gung Memorial Hospital | 30 | 2027-01-01 | 2026-07-24 | |
| Sarcoma and Intra-infusion Exercise for Better Outcomes Exercise - Sarcoma | Not applicable | Not yet recruiting | Kira Bloomquist | 16 | 2027-01-01 | 2026-08-25 |
| Tumor-Lymph Node Mapping ICG (Indocyanine Green) - Pediatric Solid Tumors, Rhabdomyosarcoma | Not yet recruiting | University of Rochester | 10 | 2026-12-13 | 2026-08-26 | |
| Acupuncture as add-on to G-CSF for Febrile Neutropenia-related Hospitalization in Doxorubicin-treated Patients With Sarcoma Acupuncture - Febrile Neutropenia, Sarcoma | Not applicable | Not yet recruiting | Shaare Zedek Medical Center | 60 | 2026-12-01 | 2026-04-29 |
| Paediatric Sarcoma, Hybrid Imaging & FAPI - Raising the Diagnostic Standard for Paediatric Sarcoma Patients, Combining Novel Radiotracer FAPI and Whole-body PET/MRI FAPI tracer - Sarcoma | Phase 2 | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 40 | 2026-12-01 | 2026-10-06 |
| Mercaptopurine for the Treatment of Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), Uterine/Cutaneous Leiomyomas, and Kidney Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Kidney Carcinoma, Advanced Renal Cell Carcinoma | Phase 1 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 18 | 2026-12-01 | 2026-08-06 |
| Treatment of Stage IV Cancer Patients With Multiple Patient-specific Mutated Cell Surface Proteins With Chimeric Antibodies Moonshot Antibodies - Soft Tissue Cancer | Phase 1 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 16 | 2026-12-01 | 2026-09-22 |
| Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma Doxorubicin - Sarcoma | Phase 2 | Recruiting | University of Colorado, Denver | 20 | 2026-12-01 | 2026-02-05 |
| Comparison of the Effects of Needle Biopsy Tract Resection and Non-resection on Recurrence Rate in Patients With Primary Extremity Sarcoma biopsy tract resection, biopsy tract non-resection - Primary, Sarcoma | Phase 2 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 3300 | 2026-12-01 | 2026-07-14 |
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Sarcoma (1602) · Osteosarcoma (469) · Leiomyoma (422) · Gastrointestinal Stromal Tumors (335) · Neoplasms (255) · Ovarian Neoplasms (248) · Sarcoma, Ewing (244) · Rhabdomyosarcoma (229) · Breast Neoplasms (220) · Melanoma (218) · Neuroblastoma (207) · Liposarcoma (158) · Leiomyosarcoma (157) · Sarcoma, Kaposi (154) · Neoplasm Metastasis (147)
Neoplasms by Histologic Type (3777) · Neoplasms (3531) · Neoplasms, Connective Tissue (1723) · Neoplasms by Site (1074) · Sarcoma (873) · Neoplasms, Muscle Tissue (852) · Urogenital Diseases (839) · Neoplasms, Glandular and Epithelial (734) · Female Urogenital Diseases and Pregnancy Complications (729) · Female Urogenital Diseases (724) · Digestive System Diseases (675) · Skin and Connective Tissue Diseases (662) · Genital Diseases (659) · Digestive System Neoplasms (646)
Doxorubicin (193) · Cyclophosphamide (131) · Ifosfamide (114) · Radiotherapy (110) · Imatinib Mesylate (91) · Gemcitabine (89) · Vincristine (70) · Cisplatin (69) · Filgrastim (69) · Etoposide (66) · Carboplatin (63) · pembrolizumab (63) · Paclitaxel (61) · Magnetic Resonance Spectroscopy (60) · Irinotecan (57)
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Robert Yarchoan, M.D. (10) · Suzanne George, MD (9) · Brigitte C Widemann, M.D. (8) · Robert Maki, MD, PhD (8) · Sandra D'Angelo, MD (8) · Seth Pollack (8) · AeRang Kim, MD, PhD (7)
PMID 31401903, PMID 32827353, PMID 37185961, PMID 22682017, PMID 30274985, PMID 35115306, PMID 36357960, PMID 38603649, PMID 17046465, PMID 21345435, PMID 21826194, PMID 28391775, PMID 31553693, PMID 31971678, PMID 32615108, PMID 33465704, PMID 33596357, PMID 34878624, PMID 35790816, PMID 37477173, PMID 37863160, PMID 40341199, PMID 11323136, PMID 12094370, PMID 14645423, PMID 16000093, PMID 16624552, PMID 17290061, PMID 17822748, PMID 18076015, PMID 18378136, PMID 18774375, PMID 19451433, PMID 19556464, PMID 19949018, PMID 21134978, PMID 21387287, PMID 21410393, PMID 21613624, PMID 21941283, PMID 22002018, PMID 23177515, PMID 23188490, PMID 23450030, PMID 24444087, PMID 24504442, PMID 24618336, PMID 24630081, PMID 25209242, PMID 25421877
U10CA180886 (33), U10CA098543 (30), 2015 (22), 2016 (22), U10CA027469 (19), 2023 (18), U10CA180868 (16), 2017 (15), 2018 (15), 2009 (13), P30CA015704 (13), U10CA032102 (13), P30CA033572 (11), 2014 (10), 2025 (10)