17 completed, 11 recruiting, 3 terminated, 2 withdrawn. 17 Phase 2, 5 Phase 3, 3 Phase 1, 2 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Surgical Timing After Preoperative Hypofractionated Radiotherapy for Localized Extremity and Trunk Soft Tissue Sarcoma hypofractionated radiotherapy (30Gy/5 fractions) and surgical resection at 1-2 weeks after treatment, hypofractionated radiotherapy (30Gy/5 fractions) and surgical resection at 4-6 weeks after treatment - Soft Tissue Sarcoma of the Trunk and Extremities | Not applicable | Not yet recruiting | Italian Sarcoma Group | 142 | 2027-01-30 | 2026-09-02 |
| Clinical Study in Adult and Young Adult Patients With Advanced Desmoplastic Small Round Cell Tumor (DSRCT) ISG-TULIPS Lurbinectedin, Irinotecan - Desmoplastic Small Round Cell Tumor | Phase 2 | Recruiting | Italian Sarcoma Group | 20 | 2025-11-21 | 2026-09-02 |
| Prospective Observational Study of Localized Angiosarcoma of Any Site: ProStars Observational - Angiosarcoma | Recruiting | Italian Sarcoma Group | 250 | 2024-03-29 | 2025-11-20 | |
| Study on TSR-042 in Advanced Clear Cell Sarcoma TSR-042 - Sarcoma, Clear Cell | Phase 2 | Terminated | Italian Sarcoma Group | 3 | 2024-01-29 | 2024-02-01 |
| Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma Trabectedin, Gemcitabine, No Intervention: Observational Cohort - Leiomyosarcoma of Ovary, Soft Tissue Sarcoma | Phase 2 | Recruiting | Italian Sarcoma Group | 100 | 2021-10-29 | 2026-03-25 |
| Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma Trabectedin - Mesenchymal Chondrosarcoma | Phase 2 | Recruiting | Italian Sarcoma Group | 16 | 2021-09-14 | 2026-03-27 |
| Observational Study in Localized Osteosarcoma Treatment of Osteosarcoma according the AIEOP/ISG OS 2021 recommendations (includes drugs, surgery, radiotherapy or any other received treatments) - Localized Osteosarcoma | Recruiting | Italian Sarcoma Group | 120 | 2021-07-30 | 2026-09-02 | |
| Observational Study on Skeletal Ewing's Sarcoma Treatment of Ewings Sarcoma of bone according clinical practice (includes drugs, surgery, radiotherapy or any other received treatments) - Ewing Sarcoma of Bone | Recruiting | Italian Sarcoma Group | 100 | 2021-06-01 | 2026-01-02 | |
| Study on Clinical Features and Outcomes of Breast Sarcoma Treatment of Breast Sarcoma according clinical practice (includes drugs, surgery or any other received treatments) - Breast Sarcoma | Recruiting | Italian Sarcoma Group | 300 | 2021-04-02 | 2026-01-02 | |
| Study of Adoptive Immunotherapy in Relapsed and Non-resectable Sarcomas After Multimodal Treatment. Autologous CIK Dose level 1, Autologous CIK Dose level 2, Autologous CIK Dose level 3 - Sarcoma | Phase 1 | Withdrawn | Italian Sarcoma Group | 2020-12-18 | 2020-12-22 | |
| Study in Low Risk Gastrointestinal Stromal Tumor (GISTs) Treatment of Low Risk GISTs according clinical practice (includes drugs, surgery or any other received treatments) - GIST | Completed | Italian Sarcoma Group | 700 | 2020-11-25 | 2024-02-01 | |
| Randomized Trial in Advanced, Metastatic or Unresectable Soft Tissue Sarcoma After Failure of Standard Treatments. Standard arm: Trabectedin in monotherapy, Experimental arm: Trabectedin + Olaparib - Advanced Soft Tissue Sarcoma | Phase 2 | Completed | Italian Sarcoma Group | 130 | 2020-05-20 | 2024-12-04 |
| Eribulin in Advanced Solitary Fibrous Tumor Eribulin - Solitary Fibrous Tumor | Phase 2 | Completed | Italian Sarcoma Group | 16 | 2019-07-17 | 2024-09-20 |
| Study on Leiomyosarcoma, Liposarcomas and Synovial Sarcoma With Trabectedin Trabectedin discontinuation, Trabectedin continuation - Leiomyosarcoma, Liposarcoma | Phase 3 | Withdrawn | Italian Sarcoma Group | 2019-02-28 | 2019-05-13 | |
| Study With Trabectedin Versus Adriamycin Plus Dacarbazine, in Patients With Advanced Solitary Fibrous Tumor Trabectedin, Adriamycin, Dacarbazine - Solitary Fibrous Tumors | Phase 2 | Completed | Italian Sarcoma Group | 23 | 2018-03-04 | 2024-12-09 |
| An Observational Study on Epithelioid Sarcoma Treatment for Epitheloid Sarcoma - Epithelioid Sarcoma | Recruiting | Italian Sarcoma Group | 100 | 2017-08-22 | 2025-11-18 | |
| A Study of Pembrolizumab in Patients With Relapsed Or Metastatic Osteosarcoma Not Eligible for Curative Surgery Pembrolizumab - Osteosarcoma | Phase 2 | Terminated | Oslo University Hospital | 12 | 2017-05-30 | 2020-10-14 |
| Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease Randomized Cohort, Prospective cohort - Chordoma | Not applicable | Recruiting | Italian Sarcoma Group | 100 | 2017-03-16 | 2026-01-02 |
| Observational Study on Endometrial Stromal Tumors Treatment for EST - Endometrial Stromal Tumors | Recruiting | Italian Sarcoma Group | 100 | 2016-10-01 | 2026-01-02 | |
| Retrospective Study of Trabectedin in Soft Tissue Sarcomas Trabectedin - Sarcoma, Soft Tissue | Completed | Italian Sarcoma Group | 510 | 2016-06-15 | 2019-05-10 |
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Sarcoma (10) · Osteosarcoma (8) · Leiomyosarcoma (3) · Liposarcoma (3) · Sarcoma, Ewing (3) · Gastrointestinal Stromal Tumors (2) · Solitary Fibrous Tumors (2) · Bone Neoplasms (1) · Chondrosarcoma, Mesenchymal (1) · Chordoma (1) · Desmoplastic Small Round Cell Tumor (1) · Endometrial Stromal Tumors (1) · Hemangiosarcoma (1) · Ichthyosis, X-Linked (1) · Liposarcoma, Myxoid (1)
Trabectedin (9) · Doxorubicin (5) · Ifosfamide (5) · Surgical Procedures, Operative (4) · Etoposide (3) · Gemcitabine (3) · Imatinib Mesylate (3) · Radiotherapy (3) · Busulfan (2) · Cyclophosphamide (2) · Dacarbazine (2) · Docetaxel (2) · Irinotecan (2) · Melphalan (2) · Sorafenib (2)
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Silvia Stacchiotti, MD (5) · Giovanni Grignani, MD (3) · Paolo G. Casali, MD (3) · Stefano Ferrari, MD (3) · Massimo Aglietta, MD (2) · Roberto Luksch, MD (2) · Alessandro Gronchi, MD (1) · Andres Poveda, MD (1) · Axel Le Cesne, MD (1) · Bruno Vincenzi, Prof/MD (1) · Elena Palassini (1) · Emanuela Palmerini, MD (1) · Federica Grosso, MD (1) · Franca Faggioli, MD (1) · Giovanni Giovanni, MD (1)
PMID 16110036, PMID 16624552, PMID 16876399, PMID 17336514, PMID 18653326, PMID 19620483, PMID 25498219, PMID 26351345, PMID 26573069, PMID 27733375, PMID 28499583, PMID 30217671, PMID 31143880, PMID 31401903, PMID 32077895, PMID 32236507, PMID 32421444, PMID 32827353, PMID 33580363, PMID 33801399, PMID 33927108, PMID 35201621, PMID 36110934, PMID 36568164, PMID 38232337, PMID 39833645, PMID 40825172, PMID 41793771
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