92 completed, 16 unknown, 6 terminated, 5 withdrawn. 126 Phase 1, 17 Phase 2.
Follow Osteoporosis: new trials by email Literature Review of Osteoporosis trials Research Report on Osteoporosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetics of Zoledronic Acid in Patients on Dialysis Zoledronic Acid Injection, 5.0 mg, single dose, Zoledronic Acid Injection, 2.5 mg, single dose - Chronic Kidney Disease, Osteoporosis | Phase 1 | Not yet recruiting | University of Campinas, Brazil | 24 | 2026-08-15 | 2026-09-10 |
| Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females Blackcurrant (BC) extract, Placebo - Postmenopausal Osteoporosis, Gut Microbiome | Phase 1 | Recruiting | University of Connecticut | 159 | 2026-07-01 | 2026-07-23 |
| Compare the Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of SAL023 and Italy-Manufactured Evenity in Healthy Subjects SAL0123, Romosozumab - Osteoporosis | Phase 1 | Enrolling by invitation | Shenzhen Salubris Pharmaceuticals Co., Ltd. | 118 | 2025-10-19 | 2026-02-03 |
| A Clinical Study Evaluating the Dermal Safety of Soluble Denosumab Microneedle Patches Microneedle with 0.24mg Denosumab, Saline Microneedle Patch, Microneedle with 1.2mg Denosumab - Osteoarthritis, Osteoarthritis (OA) of the Knee | Phase 1 | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 12 | 2025-07-31 | 2025-07-25 |
| Intravenous Infusion of Human Mesenchymal Stem Cells (HMM910 ) in Postmenopausal Women With Osteoporosis at High Risk of Fracture Human Umbilical Cord-derived Mesenchymal stem cell - Osteoporosis in Post-menopausal Women, Osteoporosis | Phase 1 | Active not recruiting | HELP Therapeutics Co., Ltd. | 9 | 2025-06-20 | 2026-02-10 |
| A Single-center, Open, Randomized, Single-dose, Cross-over Bioequivalence Study to Evaluate the Effects of the Test Formulation Abalparatide Injection and the Reference Formulation Abalparatide Injection (Tymlos®) in Healthy Adult Subjects Test (T), Reference (R) - Osteoporosis | Phase 1 | Not yet recruiting | The Affiliated Hospital of Qingdao University | 32 | 2025-01-02 | 2024-12-31 |
| A Study of TeriQ Patch in Healthy Adult Female Participants TeriQ Patch, Teribone Inj., Forteo Inj. - Osteoporosis | Phase 1 | Completed | QuadMedicine | 24 | 2024-10-25 | 2025-07-25 |
| SB: Promoting Bone Health in Women Multicomponent Exercise - Osteoporosis | Phase 1 / Phase 2 | Completed | Instituto Politécnico de Bragança | 40 | 2024-10-01 | 2025-05-06 |
| Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SHR-2017 Injection in Postmenopausal Women SHR-2017 injection, Placebo - Osteoporosis | Phase 1 | Unknown | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | 45 | 2023-07-04 | 2023-07-17 |
| Assess Safety and Compare PK of New Oral hPTH(1-34) Tablet Formulations vs. EBP05 Tablets and Subcutaneous Forteo EBP05, Forteo 0.02 mg, EBP11 - Hypoparathyroidism, Osteoporosis | Phase 1 | Completed | Entera Bio Ltd. | 45 | 2023-05-11 | 2026-02-17 |
| A Study of Romosozumab in Women With Multiple Myeloma and Osteoporosis Romosozumab - Osteoporosis, Multiple Myeloma | Phase 1 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 10 | 2023-03-07 | 2025-12-19 |
| Mesenchymal Stem Cells for Age-Related Frailty Mesenchymal Stem Cells (MSCs) - Frailty | Phase 1 / Phase 2 | Withdrawn | VA Office of Research and Development | 2023-01-31 | 2023-02-06 | |
| Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for Osteoporosis AlloRx - Osteoporosis | Phase 1 | Withdrawn | The Foundation for Orthopaedics and Regenerative Medicine | 2022-12-08 | 2025-04-08 | |
| A First-in-Human Study Evaluating AGA2118 in Men and Postmenopausal Women AGA2118, Placebo - Osteoporosis | Phase 1 | Completed | Angitia Biopharmaceuticals | 90 | 2022-06-28 | 2024-02-05 |
| TST002 Intervenous Injection in Postmenopausal Women and Men With Reduced Bone Mineral Density TST002 Injection, placebo - Osteoporosis | Phase 1 | Unknown | HJB (Hangzhou) Co., Ltd. | 32 | 2022-04-28 | 2022-05-26 |
| Comparing of the Pharmacokinetic, Safety and Immunogenicity of HS-20090-2 Injection and Prolia® in Healthy Adults HS-20090-2, Prolia - Postmenopausal Osteoporosis | Phase 1 | Unknown | Shanghai Hansoh Biomedical Co., Ltd | 174 | 2021-07-26 | 2021-08-25 |
| Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis and CVD Risk blackcurrant (BC) extract - Postmenopausal Osteoporosis, Gut Microbiota | Phase 1 | Completed | University of Connecticut | 51 | 2021-07-20 | 2025-08-12 |
| Study to Evaluate and Compare the Bioequivalence of Two Abaloparatide-sMTS Treatments in Healthy Women. abaloparatide-sMTS (Patheon), abaloparatide-sMTS (Kindeva) - Osteoporosis | Phase 1 | Completed | Radius Health, Inc. | 36 | 2020-11-16 | 2022-01-06 |
| Study to Evaluate and Compare the PK Profiles of Abaloparatide-SC and Abaloparatide-sMTS in a Cohort of Healthy Men and Healthy Women. abaloparatide-sMTS, abaloparatide-SC - Healthy Volunteers | Phase 1 | Completed | Radius Health, Inc. | 52 | 2020-11-16 | 2022-01-06 |
| A Multiple Dose Study to Evaluate the Effect of SHR-1222 Injection in Postmenopausal Osteoporosis Patients SHR-1222, Placebo - Osteoporosis | Phase 1 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 107 | 2020-08-25 | 2023-07-06 |
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Osteoporosis, Postmenopausal (24) · Bone Diseases, Metabolic (14) · Bone Resorption (4) · Cardiovascular Diseases (3) · Endocrine System Diseases (3) · Fractures, Bone (3) · Musculoskeletal Diseases (3) · Arthritis (2) · Bone Diseases (2) · Cognitive Dysfunction (2) · Osteoarthritis (2) · Anxiety Disorders (1) · Arthritis, Juvenile (1) · Arthritis, Rheumatoid (1)
Metabolic Diseases (126) · Nutritional and Metabolic Diseases (126) · Bone Diseases (124) · Musculoskeletal Diseases (123) · Bone Diseases, Metabolic (112) · Pathological Conditions, Signs and Symptoms (6) · Joint Diseases (4) · Pathologic Processes (4) · Rheumatic Diseases (4) · Wounds and Injuries (4) · Cardiovascular Diseases (3) · Immune System Diseases (3) · Mental Disorders (3) · Signs and Symptoms (3)
Denosumab (9) · Cholecalciferol (7) · Teriparatide (7) · odanacatib (6) · Alendronate (4) · Calcium (4) · Risedronic Acid (4) · romosozumab (4) · Parathyroid Hormone-Related Protein (3) · Calcitriol (2) · Dietary Fiber (2) · Drug Evaluation (2) · Melatonin (2) · Parathyroid Hormone (2) · Phytosterols (2)
GlaxoSmithKline (10) · Merck Sharp & Dohme LLC (7) · Amgen (5) · Novartis (5) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (4) · Eli Lilly and Company (3) · Organon and Co (3) · Purdue University (3) · Radius Health, Inc. (3) · Shenzhen Salubris Pharmaceuticals Co., Ltd. (3) · University of Pittsburgh (3) · Warner Chilcott (3) · Addpharma Inc. (2) · Asahi Kasei Therapeutics Corporation (2) · Duquesne University (2)
United States (52) · China (15) · South Korea (6) · Denmark (4) · Japan (4) · Australia (3) · Spain (3) · United Kingdom (3) · Brazil (2) · France (2) · Germany (2) · Netherlands (2) · Singapore (2) · Taiwan (2) · Antigua and Barbuda (1)
Connie M Weaver, PhD (2) · Mara J. Horwitz, MD (2) · Paula A Witt-Enderby, PhD (2) · Amy Sun, MD, PhD (1) · Berdine R Martin, PhD (1)
PMID 21148044, PMID 23013236, PMID 15883634, PMID 16076940, PMID 16087995, PMID 17146025, PMID 18359949, PMID 19055791, PMID 19244376, PMID 19953837, PMID 20497785, PMID 21143878, PMID 21448918, PMID 21740089, PMID 21749263, PMID 21766228, PMID 22089183, PMID 22136481, PMID 22220591, PMID 22289659, PMID 22382875, PMID 23118932, PMID 24120120, PMID 24276460, PMID 24909799, PMID 25163590, PMID 25271941, PMID 25515208, PMID 25748293, PMID 25844619, PMID 26136594, PMID 26245807, PMID 26402159, PMID 26774115, PMID 28011809, PMID 29330573, PMID 29933364, PMID 29954374, PMID 30243503, PMID 30341095, PMID 33638863, PMID 34744750, PMID 35004805, PMID 35140619, PMID 35704085, PMID 36892190, PMID 36905458, PMID 37269909, PMID 39019119, PMID 42727576
2009 (1), 2025 (1), K23AR048616 (1), K23RR016047 (1), M01RR000036 (1), P50AT000477 (1), R01AR043740 (1), R01AR053701 (1), R01DK051081 (1), R21AT003735 (1)