34 completed, 4 unknown, 1 active not recruiting, 1 terminated. 28 Not applicable, 5 Phase 3, 3 Phase 2, 3 Phase 4, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 28 | Completed 22, Unknown 4, Active not recruiting 1, Terminated 1 |
| Phase 3 | 5 | Completed 5 |
| Phase 2 | 3 | Completed 3 |
| Phase 4 | 3 | Completed 3 |
| Phase 1 | 2 | Completed 2 |
| Early Phase 1 | 1 | Completed 1 |
Follow this drug Literature Review of Phytosterols trials Research Report on Phytosterols
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Functionality of an Extract Rich in Phytosterols and Phytostanols on Parameters Related to the Lipid Profile of Individuals With Hypercholesterolemia, Mainly in the Levels of Total Cholesterol, LDL Cholesterol and Oxidized LDL Plant based extract rich in phytosterols and phytostanols resveratrol and hydroxytyrosol., Placebo - Cholesterol Lowering, LDL Level | Not applicable | Completed | Centro de Edafología y Biología Aplicada del Segura | 45 | 2025-01-14 | 2025-05-01 |
| An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH) Placebo phytosterol, Placebo krill oil, Phytosterol - Familial Hypercholesterolemia | Not applicable | Active not recruiting | Hospital do Coracao | 300 | 2024-10-23 | 2026-05-12 |
| Plant Sterols on Cardiovascular Markers, Microbiota and Sterol Metabolism (Cardiofoodsterol) Plant sterols 2g/day, Placebo - Cardiovascular Diseases, Hypercholesterolemia | Not applicable | Unknown | University of Valencia | 42 | 2024-05-21 | 2024-07-01 |
| Effects of Phytosterol Supplementation on Liver Function and Inflammatory Status in Patients With Nonalcoholic Fatty Liver Disease phytosterols, placebo - NAFLD, Insulin Resistance | Not applicable | Completed | University of Jordan | 27 | 2023-08-15 | 2026-05-08 |
| Clinical Study With Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiChol Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiChol - Dyslipidemias | Not applicable | Unknown | University of Pavia | 36 | 2023-06-07 | 2024-04-01 |
| Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Patients With Familial Hypercholesterolemia phytosterol, krill oil, Placebo phytosterol - Familial Hypercholesterolemia | Not applicable | Completed | Hospital do Coracao | 58 | 2023-05-22 | 2025-12-30 |
| Diet and Plant Sterols in the Control of Cholesterolemia (DESCO) Plant sterols 2.5 g/day, Placebo - Hypercholesterolemia | Not applicable | Completed | University of Bologna | 50 | 2021-10-01 | 2024-01-31 |
| Supplements, Placebo, or Rosuvastatin Study Fish Oil, Cinnamon, Garlique,Turmeric, Plant Sterol, Red Yeast Rice, Rosuvastatin, Placebo - Hypercholesterolemia | Phase 2 | Completed | The Cleveland Clinic | 203 | 2021-04-23 | 2023-05-25 |
| Impact of Plant Sterol Supplement on LDL-C Lowering in Low-to-Moderate Risk South Asian Patients Plant Sterol - Cardiovascular Risk Factor | Phase 4 | Completed | Stanford University | 50 | 2020-01-06 | 2022-04-27 |
| Impact of Consuming Plant Sterols on Endothelial Function and Blood Pressure plant sterols, healthy diet - Cardiovascular Diseases, Endothelial Dysfunction | Not applicable | Completed | National University of Singapore | 20 | 2019-12-09 | 2021-09-08 |
| Therapeutic Efficacy of Phytosterols on Metabolic Syndrome Phytosterols, Titanium Dioxide - Metabolic Syndrome x | Not applicable | Completed | Universidad de los Andes, Chile | 220 | 2018-01-08 | 2020-03-17 |
| Genetic Basis for Prediction of Non-responders to Dietary Plant Sterol Intervention Plant sterols, Placebo - Hypercholesterolemia, Cardiovascular Disease | Not applicable | Terminated | University of Manitoba | 43 | 2017-07-05 | 2020-06-01 |
| The Effects of a Spread With Added Plant Sterols and Omega-3 Fatty Acids on Blood Lipids Margarine enriched with plant sterols and fish oil, Placebo margarine - Vascular Diseases, Hypercholesterolemia | Not applicable | Completed | Unilever R&D | 260 | 2016-04-01 | 2017-01-19 |
| Effect On Serum Cholesterol Of Dairy Products With Addition Of Esterified Phytosterols Phytosterol, Placebo - Dyslipidemias, Hypercholesterolemia | Phase 4 | Completed | University of Chile | 52 | 2015-10-01 | 2016-09-12 |
| Lipid-lowering Effect of Phytosterols, Red Yeast Rice and Their Combination Plant sterols, Red Yeast Rice, Red Yeast Rice plus Plant sterols - Hypercholesterolemia | Not applicable | Completed | University of Bologna | 60 | 2015-04-01 | 2024-02-01 |
| The Effect of Plant Sterols on the Blood Lipid Profile of Subjects With and at High Risk of Type 2 Diabetes Mellitus Plant sterols, Placebo product - Vascular Diseases, Hypercholesterolemia | Not applicable | Completed | Unilever R&D | 150 | 2014-10-01 | 2017-01-19 |
| Food Matrix and Genetic Variability as Determinants of Bioavailability and Biological Effects of Beta-cryptoxanthin and Phytosterols b-cryptoxanthin plus phytosterols - Hypercholesterolemia, Osteoporosis | Phase 1 | Completed | Puerta de Hierro University Hospital | 40 | 2014-03-01 | 2018-04-10 |
| A Clinical Study for Evaluating the Safety of a Plant Sterol-enriched Fermented Dairy Product in Japanese Healthy Adults 1-Fermented Dairy Product with Phytosterols (test), 2-Fermented dairy Product with No Phytosterols (control) - Healthy Volunteers | Not applicable | Completed | Danone Japan | 84 | 2014-02-01 | 2014-10-30 |
| "A Clinical Study for Evaluating the Effect of a Plant Sterol-enriched Fermented Dairy Product on Blood Lipoprotein Profile in Japanese Adults" 1-Fermented Dairy Product with Phytosterols (test), 2-Fermented dairy Product with No Phytosterols (control) - Subjects With High LDL-Cholesterol | Not applicable | Completed | Danone Japan | 154 | 2014-01-01 | 2016-10-27 |
| Comparison of the Efficacy of Plant Sterol-Enriched Soymilk Versus Plain Soymilk in Volunteers With High LDL-Cholesterol plant sterol and soluble fiber-enriched soymilk, soymilk - Hypercholesterolemia | Not applicable | Completed | Chiang Mai University | 242 | 2013-04-01 | 2015-06-02 |
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Hypercholesterolemia (15) · Cardiovascular Diseases (4) · Dyslipidemias (4) · Hyperlipidemias (4) · Metabolic Syndrome (3) · Vascular Diseases (3) · Coronary Disease (2) · Diabetes Mellitus (2) · Hyperlipoproteinemia Type II (2) · Non-alcoholic Fatty Liver Disease (2) · Obesity (2) · Osteoporosis (2) · Atherosclerosis (1) · Coronary Artery Disease (1) · Hypertension (1)
Unilever R&D (4) · Danone Japan (3) · University of Manitoba (3) · Danone Global Research & Innovation Center (2) · Hospital do Coracao (2) · Puerta de Hierro University Hospital (2) · University of Bologna (2) · Centre for Chronic Disease Control, India (1) · Centro de Edafología y Biología Aplicada del Segura (1) · Chestnut Hill Health System (1) · Chiang Mai University (1) · China Medical University Hospital (1) · Danone Spain (1) · Institut Pertanian Bogor (1) · Jose Rocha Faria Neto (1)
United States (6) · Canada (5) · Spain (5) · Brazil (3) · Germany (3) · Italy (3) · Japan (3) · Chile (2) · Finland (2) · Australia (1) · India (1) · Jordan (1) · Singapore (1) · Sweden (1) · Taiwan (1)
Aline Marcadenti, PhD (2) · Erlon O Abreu-Silva, MSc (2) · Wieneke Koppenol, MSc (2) · Adriana B Carvalho, PhD (1) · Alexandre B Cavalcanti, PhD (1) · Angela C Bersch-Ferreira, PhD (1) · Anneli Hallmin (1) · Birgitta Sundberg, PhD (1) · Claudio Borghi, MD (1) · Conrad Earnest, PhD (1) · Dalong Chen, M.D. (1) · David J Becker, MD (1) · Dugald Seely, ND (1) · Dylan Mackay, PhD (1)
PMID 11781675, PMID 16404415, PMID 16923260, PMID 18762410, PMID 21768544, PMID 23630244, PMID 23816039, PMID 24451612, PMID 24909799, PMID 25122648, PMID 25163590, PMID 25733626, PMID 25809853, PMID 26333513, PMID 26806045, PMID 28620471, PMID 29021813, PMID 29725824, PMID 29795368, PMID 30243503, PMID 32487131, PMID 32785036, PMID 36351465, PMID 37960208, PMID 39561689, PMID 42285576, PMID 7566021
R01HL050420 (1)