9 completed, 1 terminated. 4 Phase 3, 3 Not applicable, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 4 |
| Not applicable | 3 | Completed 3 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Heroin: new trials by email Literature Review of Heroin trials Research Report on Heroin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV buprenorphine/naloxone, Methadone, Naltrexone Injection - HIV Infection, Opioid-use Disorder | Completed | MetroHealth Medical Center | 190 | 2017-07-14 | 2023-10-02 | |
| Does Adding Spinal Anaesthesia to a General Anaesthetic Technique Influence Readiness for Discharge in Patients Having Hand Assisted Laparoscopic Live Donor Nephrectomy Bupivacaine and Diamorphine, Remifentanil, Propofol and Cistracurium, Bupivacaine and Rectus Sheath injection - Surgery | Not applicable | Completed | Manchester University NHS Foundation Trust | 101 | 2016-03-16 | 2020-03-17 |
| Pain Relief After Colorectal Surgery: Spinal Combined With Painbuster® vs Painbuster® Alone. Spinal and infusion of local anaesthetic, Continuous infusion of local anaesthetic, Bupivacaine - Colorectal Cancer | Not applicable | Completed | York Teaching Hospitals NHS Foundation Trust | 79 | 2013-09-01 | 2016-09-14 |
| Study to Assess Longer-term Opioid Medication Effectiveness (SALOME) Hydromorphone, Injectable, Diacetylmorphine, injectable, Hydromorphone, liquid oral - Opioid Dependence, Heroin Dependence | Phase 3 | Completed | University of British Columbia | 202 | 2011-12-01 | 2016-06-07 |
| Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine Ibuprofen, Placebo, Diamorphine or Morphine - Sickle Cell Disease | Phase 4 | Terminated | London North West Healthcare NHS Trust | 320 | 2011-03-01 | 2012-12-04 |
| Diamorphine or Alfentanil for Subcutaneous Use in Hospice In-patients? Alfentanil, Diamorphine - Cancer | Not applicable | Completed | Gloucestershire Hospitals NHS Foundation Trust | 18 | 2010-09-01 | 2015-03-17 |
| Effects of Diacetylmorphine (DAM) on Brain Function and Stress Response diacetylmorphine (DAM), Placebo - Opiate | Phase 1 | Completed | University Hospital, Basel, Switzerland | 60 | 2010-03-01 | 2015-10-15 |
| Abuse Liability of Suboxone Versus Subutex Heroin, Naloxone, Low Bup Dose - Opioid-related Disorders | Phase 3 | Completed | New York State Psychiatric Institute | 19 | 2007-09-01 | 2016-12-05 |
| NAOMI: A Study to Compare Medically-prescribed Heroin With Oral Methadone in Chronic Opiate Addiction Methadone, Diamorphine hydrochloride - Opiate Addiction | Phase 3 | Completed | University of British Columbia | 192 | 2005-03-01 | 2014-09-29 |
| The German Project of Heroin Assisted Treatment of Opiate Dependent Patients Diacetylmorphine, Psycho-education and Counselling, Methadone - Opioid Dependence | Phase 3 | Completed | Universitätsklinikum Hamburg-Eppendorf | 1015 | 2002-03-01 | 2015-09-09 |
Opioid-Related Disorders (5) · Neoplasms (2) · Anemia, Sickle Cell (1) · Cardiovascular Diseases (1) · Colorectal Neoplasms (1) · HIV Infections (1) · Heroin Dependence (1) · Inflammation (1) · Pain (1) · Substance-Related Disorders (1)
University of British Columbia (2) · Gloucestershire Hospitals NHS Foundation Trust (1) · London North West Healthcare NHS Trust (1) · Manchester University NHS Foundation Trust (1) · MetroHealth Medical Center (1) · New York State Psychiatric Institute (1) · University Hospital, Basel, Switzerland (1) · Universitätsklinikum Hamburg-Eppendorf (1) · York Teaching Hospitals NHS Foundation Trust (1)
United Kingdom (4) · Canada (2) · United States (2) · Germany (1) · Switzerland (1)
Caroline Dore, BSc (1) · Christian Haasen, MD (1) · Corrilynn O Hileman, MD (1) · Daniel Harper, MBChB, FRCA (1) · Dieter Naber, MD (1) · Eugenia Oveido-Joekes, Ph.D. (1) · Gavin Cho, MD (1) · Grace A McComsey, MD (1) · Kofi A Anie, PhD (1) · Marc Walter, MD (1) · Mark Layton, MD (1) · Martin T Schechter, MD, PhD (1) · Michael R Krausz, M.D. (1) · Paul Perkins, MBBCh FRCP (1) · Sandra D Comer, PhD (1)
PMID 19159475, PMID 19692689, PMID 20403021, PMID 21791093, PMID 22276954, PMID 24908387, PMID 25262567, PMID 25619263, PMID 27049826, PMID 27288381, PMID 28526048, PMID 33009185
R01DA044576 (1)