4 unknown, 3 completed, 2 enrolling by invitation, 2 terminated. 5 Phase 2, 4 Phase 3, 3 Not applicable, 1 Phase 4.
Follow Opiate Substitution Treatment: new trials by email Literature Review of Opiate Substitution Treatment trials Research Report on Opiate Substitution Treatment
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing the Efficacy of the LDA, LHAA, and DA Regimens in Young Adults With Low-Risk Acute Myeloid Leukemia Eligible for Intensive Chemotherapy Lisaftoclax+daunorubicin+cytarabine, Lisaftoclax+homoharringtonine+cytarabine+aclarubicin, Daunorubicin+cytarabine - Acute Myeloid Leukemia, Lisaftoclax | Phase 2 / Phase 3 | Enrolling by invitation | First Affiliated Hospital of Zhejiang University | 267 | 2026-03-01 | 2026-06-16 |
| Comparing the Efficacy of LDA, LHAA, and LA Regimens in Young Adults With Intermediate- and High-Risk Acute Myeloid Leukemia Eligible for Intensive Chemotherapy Lisaftoclax+daunorubicin+cytarabine, Lisaftoclax+homoharringtonine+cytarabine+aclarubicin, Lisaftoclax+azacitidine - Acute Myeloid Leukemia (AML), Lisaftoclax | Phase 2 / Phase 3 | Enrolling by invitation | First Affiliated Hospital of Zhejiang University | 450 | 2026-03-01 | 2026-06-16 |
| Neoadjuvant Treatment of Ovarian Cancer With Fuzuloparib in Combination With Apatinib Neoadjuvant therapy with fuzuloparib in combination with apatinib, Preoperative Period, Chemotherapy - Ovarian Cancer | Phase 2 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 48 | 2025-06-25 | 2026-02-27 |
| Fruquintinib Plus FOLFIRI in RAS-mutated Metastatic Colorectal Cancer intensive treatment, Maintenance treatment - Colorectal Cancer | Phase 2 | Unknown | Hunan Cancer Hospital | 42 | 2023-10-01 | 2023-08-01 |
| Comparison of VER-01 to Opioids in Patients With Chronic Non-specific Low Back Pain VER-01, Opioid therapy - Chronic Non-specific Low Back Pain | Phase 3 | Completed | Vertanical GmbH | 384 | 2023-06-08 | 2024-11-25 |
| Effects on Mortality and Clinical Course of a Patient's Choice Model for Opioid Maintenance Treatment for Opioid Dependence - Evaluation of a System Enabling a Large Expansion of Treatment Providers and Treatment Access Opioid maintenance treatment - Opioid Dependence, Overdose | Unknown | Region Skane | 2500 | 2023-01-31 | 2023-01-10 | |
| Phase Ⅱ Study of Chidamide in Combination With CHOP in Previously Untreated Peripheral T-Cell Lymphoma With Follicular Helper of T Cell Phenotype Chidamide combined with CHOP, Chidamide - Peripheral T-Cell Lymphoma With Follicular Helper of T Cell Phenotype | Phase 2 | Unknown | Sun Yat-sen University | 47 | 2022-09-01 | 2022-10-10 |
| Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder Medication Assisted Treatment - Opioid-use Disorder, Opioid Dependence | Not applicable | Unknown | University of Colorado, Denver | 303 | 2021-05-13 | 2024-04-09 |
| Patient-Centered Care for Opioid Use Disorders in Federally Qualified Healthcare Centers and Specialty Care Settings Individual Therapy Sessions, Cognitive Behavioral Therapy (CBT), Medication-Assisted Treatment - Opioid-use Disorder, Substance Use Disorders | Not applicable | Withdrawn | Public Health Management Corporation | 2019-07-01 | 2019-06-21 | |
| Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy Ibuprofen, Opioid Medication, Placebo - Pain, Hernia | Phase 3 | Terminated | Mike O'Callaghan Military Hospital | 18 | 2018-07-05 | 2024-03-26 |
| Expanded HIV Care in Opioid Substitution Treatment (EHOST) Trial Expanded HIV care in Opioid Substitution Treatment - Opioid Use Disorder, HIV | Not applicable | Completed | Simon Fraser University | 49 | 2015-09-01 | 2017-04-25 |
| Antipsychotic Induced Structural and Functional Brain Changes Maintenance treatment, Intermittent treatment - Schizophrenia | Phase 4 | Terminated | RWTH Aachen University | 174 | 2015-05-01 | 2020-11-25 |
| Completion of OST - a Prospective Study Opiate Substitution Treatment - Opioid Dependence | Completed | Universitätsklinikum Hamburg-Eppendorf | 78 | 2011-07-01 | 2019-10-09 |
Opioid-Related Disorders (5) · Leukemia, Myeloid, Acute (2) · Colorectal Neoplasms (1) · Drug Overdose (1) · Hernia (1) · Ovarian Neoplasms (1) · Pain (1) · Schizophrenia (1) · Substance-Related Disorders (1) · Treatment Adherence and Compliance (1)
First Affiliated Hospital of Zhejiang University (2) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · Hunan Cancer Hospital (1) · Mike O'Callaghan Military Hospital (1) · Public Health Management Corporation (1) · RWTH Aachen University (1) · Region Skane (1) · Simon Fraser University (1) · Sun Yat-sen University (1) · University of Colorado, Denver (1) · Universitätsklinikum Hamburg-Eppendorf (1) · Vertanical GmbH (1)
China (5) · Germany (2) · United States (2) · Sweden (1)
Bohdan Nosyk, PhD (1) · David R Gastfriend, MD (1) · Jens Reimer, Professor (1) · Klaus Mathiak, Univ.-Prof. Dr. Dr. (1) · Matthias Karst, Prof.Dr.med. (1) · Qingqing Cai (1)