4 completed, 4 unknown, 3 not yet recruiting, 1 enrolling by invitation. 5 Not applicable, 3 Phase 4, 2 Phase 3, 1 Phase 2.
Follow Opioid Analgesic Adverse Reaction: new trials by email Literature Review of Opioid Analgesic Adverse Reaction trials Research Report on Opioid Analgesic Adverse Reaction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Serratus and Pectoralis II Plane Block Versus Pectoralis II Alone on Acute Postoperative Pain After Mastectomy Serratus Anterior Plane Block (SAPB) group, Pectoral nerve block (PECS) - Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection | Not applicable | Not yet recruiting | Lebanese American University | 80 | 2026-12-01 | 2026-10-19 |
| Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia. Spinal analgesia, Epidural Analgesia - Pruritis, Hypotension Drug-Induced | Not applicable | Not yet recruiting | St. Justine's Hospital | 80 | 2026-01-01 | 2025-11-26 |
| the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery Oliceridine Injection [Olinvyk], Sufentanil Citrate - Acute Pain, Opioid Analgesic Adverse Reaction | Phase 4 | Not yet recruiting | Xiangya Hospital of Central South University | 606 | 2025-08-01 | 2025-08-19 |
| Postoperative Analgesia Intervention With Non-opioid Alternatives (PAIN-Alt) Trial - Breast Surgery Opioid Analgesia (OA) [Multimodal analgesia including opioid drugs], Opioid-Free Analgesia (OFA) [Multimodal analgesia not including opioid drugs] - Post Operative Pain, Opioid Analgesic Adverse Reaction | Not applicable | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 540 | 2024-11-26 | 2025-01-13 |
| Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity Naproxen, Acetaminophen, oxycodone - Opioid Abuse (Disorder), Opioid Analgesia | Phase 4 | Enrolling by invitation | AdventHealth | 300 | 2024-08-01 | 2026-10-08 |
| Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery Dexmedetomidine, Acetaminophen, Ketorolac - Tonsillitis, Post-operative Nausea and Vomiting (PONV) | Not applicable | Completed | Boston Children's Hospital | 62 | 2024-05-09 | 2026-05-18 |
| Validation of a Screening Scale for Misuse of Opioid Analgesics Questionnaires - Cancer, Pain | Unknown | University Hospital, Clermont-Ferrand | 150 | 2023-02-23 | 2023-07-18 | |
| Comparison of an Opioid-Free Anesthesia Protocol Versus Standard Practices on Early and Late Post-operative Recovery Opioid Free Anaesthesia protocol, standard practice protocol based on the use of opioids (sufentanil or remifentanil) - Anesthesia, Anesthesia; Adverse Effect | Phase 3 | Unknown | University Hospital, Angers | 140 | 2021-07-12 | 2021-10-14 |
| Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia Esketamine, Sulfentanil or/and Remifentanil - Opioid Analgesic Adverse Reaction | Not applicable | Unknown | Second Hospital of Shanxi Medical University | 1000 | 2020-11-02 | 2024-01-25 |
| Celecoxib vs. Acetaminophen/Codeine/Caffeine for Post-operative Analgesia in Rhinoplasty. Celecoxib 200mg, Acetaminophen, Codeine Drug Combination - Pain, Postoperative, Surgery--Complications | Phase 4 | Unknown | Blake Raggio | 60 | 2020-03-01 | 2020-08-04 |
| Role of Prophylactic Metoclopramide With Tramadol in Trauma Patients Tramadol, Metoclopramide, Placebo - Trauma, Opioid Analgesic Adverse Reaction | Phase 2 | Completed | University of Malaya | 191 | 2017-07-01 | 2017-12-26 |
| Combination of Nitrous Oxide 70% With Fentanyl Intranasal for Procedural Analgosedation in Children Fentanyl intranasal, NaCl 0.9% intranasal - Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction | Phase 3 | Completed | University Children's Hospital, Zurich | 402 | 2015-09-21 | 2017-10-26 |
| Safety and Tolerability of Controlled-release Oxycodone on Postoperative Pain in Oncologic Head and Neck Surgery Controlled-release oxycodone - Postoperative Nausea, Adverse Effects | Completed | Instituto Nacional de Cancer, Brazil | 83 | 2010-10-01 | 2013-04-18 |
Pain (4) · Pain, Postoperative (4) · Acute Pain (1) · Agnosia (1) · Breast Diseases (1) · Breast Neoplasms (1) · Emergence Delirium (1) · Hypotension (1) · Nausea (1) · Neoplasms (1) · Opioid-Related Disorders (1) · Patient Satisfaction (1) · Postoperative Complications (1) · Postoperative Nausea and Vomiting (1) · Pruritus (1)
Pathological Conditions, Signs and Symptoms (11) · Signs and Symptoms (10) · Neurologic Manifestations (9) · Pathologic Processes (7) · Postoperative Complications (6) · Pain (5) · Signs and Symptoms, Digestive (3) · Skin Diseases (3) · Skin and Connective Tissue Diseases (3) · Mental Disorders (2) · Nervous System Diseases (2) · Neurobehavioral Manifestations (2) · Behavior (1) · Breast Diseases (1) · Cardiovascular Diseases (1)
Acetaminophen (3) · Sufentanil (2) · ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine (1) · Analgesia, Epidural (1) · Analgesics, Opioid (1) · Atracurium (1) · Celecoxib (1) · Dexmedetomidine (1) · Esketamine (1) · Fentanyl (1) · Gabapentin (1) · Injections, Epidural (1) · Ketorolac (1) · Ketorolac Tromethamine (1) · Metoclopramide (1)
AdventHealth (1) · Blake Raggio (1) · Boston Children's Hospital (1) · Instituto Nacional de Cancer, Brazil (1) · Lebanese American University (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Second Hospital of Shanxi Medical University (1) · St. Justine's Hospital (1) · University Children's Hospital, Zurich (1) · University Hospital, Angers (1) · University Hospital, Clermont-Ferrand (1) · University of Malaya (1) · Xiangya Hospital of Central South University (1)
Canada (3) · China (2) · France (2) · United States (2) · Brazil (1) · Lebanon (1) · Malaysia (1) · Switzerland (1)
Amir Kachooei, MD PhD (1) · Ismar L Cavalcanti, MD PhD (1) · Jamil Asaria, MD (1) · Julio Flavio Fiore, PhD (1) · Michelle Seiler (1) · Virginie Guastella (1)