12 recruiting. 12 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Recruiting 12 |
| Phase 1 | 2 | Recruiting 2 |
Follow Obsessive-Compulsive Disorder: new trials by email Literature Review of Obsessive-Compulsive Disorder trials Research Report on Obsessive-Compulsive Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SONATA LIFU for OCD Low Intensity Focused Ultrasound, Sham (No Treatment) - Obsessive Compulsive Disorder | Phase 2 | Recruiting | University of Pennsylvania | 40 | 2026-07-01 | 2026-07-27 |
| Pilot Study of RR-HNK in OCD RR-HNK/Hydroxynorketamine, Placebo - Obsessive-Compulsive Disorder | Phase 1 / Phase 2 | Recruiting | Carolyn Rodriguez | 45 | 2026-01-23 | 2026-08-12 |
| MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study) 3,4-Methyl enedioxy methamphetamine, Methamphetamine, Cognitive Behavioral Therapy (CBT) - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Carolyn Rodriguez | 40 | 2025-09-10 | 2026-03-05 |
| Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness Transcranial magnetic stimulation - Major Depressive Disorder, Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Brigham and Women's Hospital | 180 | 2025-01-30 | 2026-07-16 |
| Evaluating the Feasibility, Safety and Efficacy of Psychotherapy Assisted Psilocybin for Treatment of Severe OCD psychotherapy assisted psilocybin - Obsessive-compulsive Disorder | Phase 2 | Recruiting | Beersheva Mental Health Center | 15 | 2024-11-25 | 2025-11-19 |
| Safety and Efficacy of Pramipexole Treatment in Resistant Obsessive-Compulsive Disorder (OCD) Pramipexole 0.088mg/tid, Pramipexole 0.18 mg/tid, Pramipexole 0.35 mg/tid - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Clinical Academic Center (2CA-Braga) | 48 | 2024-08-20 | 2025-01-06 |
| Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2) Ketamine, Naltrexone Pill, Placebo pill - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Stanford University | 150 | 2024-02-24 | 2026-04-24 |
| Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults Valbenazine Oral Capsule, Placebo Oral capsule - Trichotillomania (Hair-Pulling Disorder) | Phase 2 | Recruiting | Yale University | 20 | 2024-02-02 | 2026-02-03 |
| Study of Dextromethorphan in OCD and Related Disorders Fluoxetine, Dextromethorphan - Obsessive-Compulsive Disorder, Illness Anxiety Disorder | Phase 2 | Recruiting | Stanford University | 60 | 2022-01-20 | 2026-05-20 |
| Efficacy of Nitrous Oxide in OCD: Pilot Study Nitrous Oxide, Nitrogen - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Stanford University | 45 | 2021-04-17 | 2025-08-27 |
| Pragmatic Trial of Obsessive-compulsive Disorder Sertraline 200 milligram(mg), Sertraline 300 milligram(mg), Fluvoxamine - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Shanghai Mental Health Center | 1600 | 2020-09-22 | 2025-05-15 |
| Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD Fluoxetine - immediate treatment, Fluoxetine - delayed treatment - Obsessive-Compulsive Disorder | Phase 1 / Phase 2 | Recruiting | Yale University | 100 | 2019-10-14 | 2026-09-22 |
Anxiety Disorders (1) · Body Dysmorphic Disorders (1) · Depression (1) · Depressive Disorder, Major (1) · Generalized Anxiety Disorder (1) · Mental Disorders (1) · Mood Disorders (1) · Schizophrenia (1) · Trichotillomania (1)
Anxiety Disorders (11) · Mental Disorders (11) · Behavior (1) · Behavioral Symptoms (1) · Depressive Disorder (1) · Disruptive, Impulse Control, and Conduct Disorders (1) · Schizophrenia Spectrum and Other Psychotic Disorders (1) · Somatoform Disorders (1)
Fluoxetine (2) · 6-hydroxynorketamine (1) · Aripiprazole (1) · Cognitive Behavioral Therapy (1) · Dextromethorphan (1) · Fluvoxamine (1) · Ketamine (1) · Memantine (1) · Methamphetamine (1) · N-Methyl-3,4-methylenedioxyamphetamine (1) · Naltrexone (1) · Nitrogen (1) · Nitrous Oxide (1) · Pramipexole (1) · Transcranial Magnetic Stimulation (1)
Stanford University (3) · Carolyn Rodriguez (2) · Yale University (2) · Beersheva Mental Health Center (1) · Brigham and Women's Hospital (1) · Clinical Academic Center (2CA-Braga) (1) · Shanghai Mental Health Center (1) · University of Pennsylvania (1)
United States (9) · China (1) · Israel (1) · Portugal (1)
Carolyn Rodriguez, MD, PhD (2) · Christopher Pittenger, MD, PhD (1) · Michael H. Bloch, MD (1) · Oded Arbel, MD (1) · Pedro Morgado, MD, PhD (1) · Peter J van Roessel, MD PhD (1) · Peter J van Roessel, MD, PhD (1) · Shan H Siddiqi, MD (1) · Zhen Wang, PhD,MD (1)
K24MH121571 (1), R01MH116038 (1), R01MH133553 (1)