26 completed, 20 recruiting, 2 terminated, 2 withdrawn. 17 Not applicable, 5 Early Phase 1, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 17 | Recruiting 8, Completed 7, Withdrawn 2 |
| Early Phase 1 | 5 | Completed 3, Not yet recruiting 1, Recruiting 1 |
| Phase 1 | 4 | Completed 4 |
Follow Normal Physiology: new trials by email Literature Review of Normal Physiology trials Research Report on Normal Physiology
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Causal Mechanisms of Odor-Guided Behavior in Humans TUS PirC, TUS Amy, TUS Sham - Normal Physiology | Early Phase 1 | Not yet recruiting | National Institute on Drug Abuse (NIDA) | 80 | 2026-11-04 | 2026-10-30 |
| Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making continuous Theta Burst Stimulation (cTBS), intermittent Theta Burst Stimulation (iTBS), sham Theta Burst Stimulation (sham TBS) - Normal Physiology | Early Phase 1 | Recruiting | National Institute on Drug Abuse (NIDA) | 600 | 2026-11-04 | 2026-10-30 |
| NIEHS Repository of Stored Biological Samples for Future Use Normal Physiology | Recruiting | National Institute of Environmental Health Sciences (NIEHS) | 2000 | 2024-07-15 | 2026-06-11 | |
| Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms Pupillometry, Light box exposure - Normal Physiology | Not applicable | Recruiting | Massachusetts General Hospital | 48 | 2023-12-01 | 2026-07-13 |
| MRI Guided Closed-loop TMS-EEG TMS - Normal Physiology, Amnestic Mild Cognitive Impairment | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 160 | 2023-09-07 | 2024-08-13 |
| The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat - Obesity, Normal Physiology | Not applicable | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 120 | 2023-06-06 | 2026-08-28 |
| Development and Validation of Learning and Decision-Making Tasks MRI - Normal Physiology | Recruiting | National Institute on Drug Abuse (NIDA) | 550 | 2023-03-29 | 2026-10-29 | |
| Defining Neurobiological Links Between Substance Use and Mental Illness Placebo Nicotine Patch, Nicotine Patch - Major Depressive Disorder, Substance Use Disorder | Not applicable | Recruiting | National Institute on Drug Abuse (NIDA) | 620 | 2023-02-02 | 2026-10-26 |
| Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects Normal Physiology | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 200 | 2023-02-02 | 2026-10-16 | |
| Characterization and Brain Mechanisms of Frustration in Youth With Severe Irritability or Attention Deficit Hyperactivity Disorder (ADHD) Affective Posner fMRI frustration induction task - Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder | Not applicable | Withdrawn | National Institute of Mental Health (NIMH) | 2023-01-05 | 2023-01-10 | |
| A Natural History Study of Metabolic Sizing in Health and Disease Metabolic Disorders, Cancer | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 2000 | 2022-10-25 | 2026-10-27 | |
| Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis No Interventions - Cancer Diagnosis, Liver Cancer, Adult | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 600 | 2022-09-01 | 2025-04-24 | |
| Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array SQUID MEG, OPM MEG - Normal Physiology | Not applicable | Recruiting | National Institute of Mental Health (NIMH) | 100 | 2022-05-12 | 2026-10-21 |
| Investigational Use of Neuromuscular Ultrasound Muscular Dystrophy, Peripheral Neuropathy | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 150 | 2022-04-18 | 2026-09-17 | |
| Addictions Neuroclinical Assessment (ANA) Normal Physiology, Alcohol Use Disorder | Enrolling by invitation | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 1400 | 2021-08-12 | 2026-10-19 | |
| Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory TMS - Normal Physiology | Not applicable | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 43 | 2021-07-09 | 2025-07-04 |
| Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex Normal Physiology | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 40 | 2021-04-21 | 2026-10-26 | |
| Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis EMG, EEG - Normal Physiology | Not applicable | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 39 | 2020-12-22 | 2024-04-05 |
| Sensory Afferents for Deep Pressure Sensation Deep pressure block - Normal Physiology | Not applicable | Completed | National Center for Complementary and Integrative Health (NCCIH) | 7 | 2019-06-20 | 2021-10-05 |
| Perception, Sensation, Cognition and Action in Humans Normal Physiology | Recruiting | National Eye Institute (NEI) | 10200 | 2019-03-26 | 2026-10-29 |
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Obesity (3) · Pain (3) · Neoplasms (2) · Stroke (2) · Alcoholism (1) · Attention Deficit Disorder with Hyperactivity (1) · Behavior (1) · Brain Injuries, Traumatic (1) · Breast Feeding (1) · Breast Neoplasms (1) · Carcinoma, Hepatocellular (1) · Colorectal Neoplasms (1) · Depressive Disorder, Major (1) · Diabetes Mellitus (1) · Esophageal Neoplasms (1)
Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (7) · Mental Disorders (6) · Nervous System Diseases (5) · Neurologic Manifestations (4) · Nutritional and Metabolic Diseases (4) · Body Weight (3) · Brain Diseases (3) · Central Nervous System Diseases (3) · Chemically-Induced Disorders (3) · Nutrition Disorders (3) · Overnutrition (3) · Overweight (3) · Behavior (2) · Cardiovascular Diseases (2)
11C-PS13 (1) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · Amoxicillin (1) · Angptl4 protein, mouse (1) · Azithromycin (1) · Coffee (1) · Electroencephalography (1) · Methylphenidate (1) · Methylprednisolone (1) · Neuropsychological Tests (1) · Nutritional Requirements (1) · Pharmaceutical Preparations (1) · Tobacco Use Cessation Devices (1) · Transcranial Magnetic Stimulation (1)
National Institute of Neurological Disorders and Stroke (NINDS) (13) · National Institute of Mental Health (NIMH) (6) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (6) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · National Center for Complementary and Integrative Health (NCCIH) (4) · National Institute on Drug Abuse (NIDA) (4) · National Cancer Institute (NCI) (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · National Institute of Environmental Health Sciences (NIEHS) (2) · National Institutes of Health Clinical Center (CC) (2) · Massachusetts General Hospital (1) · National Eye Institute (NEI) (1) · National Institute on Aging (NIA) (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Sunnybrook Health Sciences Centre (1)
United States (49) · Canada (1) · China (1) · Mongolia (1)
Dardo G Tomasi, Ph.D. (4) · Eric M Wassermann, M.D. (4) · Thorsten Kahnt, Ph.D. (3) · Kong Y Chen, Ph.D. (2) · Lauren Y Atlas, Ph.D. (2) · Leonardo G Cohen, M.D. (2) · Mark Hallett, M.D. (2) · Alexander T Chesler, Ph.D. (1) · Allison C Nugent, Ph.D. (1) · Amy C Janes, Ph.D. (1) · Bevil R Conway, Ph.D. (1) · Carlo M Pierpaoli, M.D. (1) · Carlos A Zarate, M.D. (1) · Christa S Zerbe, M.D. (1) · David S Goldstein, M.D. (1)
PMID 24464944, PMID 26285132, PMID 28416813, PMID 28867340, PMID 30050047, PMID 30243817, PMID 31150063, PMID 32399622, PMID 32659786, PMID 33630047, PMID 33724063, PMID 34264865, PMID 35189353, PMID 36317867, PMID 36765261, PMID 36772948, PMID 37633900, PMID 37777515, PMID 37938560, PMID 38109535, PMID 38326458, PMID 40101961, PMID 40721322, PMID 41230818, PMID 41921573, PMID 42083927