8 recruiting, 7 completed, 2 withdrawn. 17 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 17 | Recruiting 8, Completed 7, Withdrawn 2 |
Follow Normal Physiology: new trials by email Literature Review of Normal Physiology trials Research Report on Normal Physiology
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms Pupillometry, Light box exposure - Normal Physiology | Not applicable | Recruiting | Massachusetts General Hospital | 48 | 2023-12-01 | 2026-07-13 |
| MRI Guided Closed-loop TMS-EEG TMS - Normal Physiology, Amnestic Mild Cognitive Impairment | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 160 | 2023-09-07 | 2024-08-13 |
| The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat - Obesity, Normal Physiology | Not applicable | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 120 | 2023-06-06 | 2026-08-28 |
| Defining Neurobiological Links Between Substance Use and Mental Illness Placebo Nicotine Patch, Nicotine Patch - Major Depressive Disorder, Substance Use Disorder | Not applicable | Recruiting | National Institute on Drug Abuse (NIDA) | 620 | 2023-02-02 | 2026-11-03 |
| Characterization and Brain Mechanisms of Frustration in Youth With Severe Irritability or Attention Deficit Hyperactivity Disorder (ADHD) Affective Posner fMRI frustration induction task - Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder | Not applicable | Withdrawn | National Institute of Mental Health (NIMH) | 2023-01-05 | 2023-01-10 | |
| Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array SQUID MEG, OPM MEG - Normal Physiology | Not applicable | Recruiting | National Institute of Mental Health (NIMH) | 100 | 2022-05-12 | 2026-10-21 |
| Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory TMS - Normal Physiology | Not applicable | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 43 | 2021-07-09 | 2025-07-04 |
| Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis EMG, EEG - Normal Physiology | Not applicable | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 39 | 2020-12-22 | 2024-04-05 |
| Sensory Afferents for Deep Pressure Sensation Deep pressure block - Normal Physiology | Not applicable | Completed | National Center for Complementary and Integrative Health (NCCIH) | 7 | 2019-06-20 | 2021-10-05 |
| Exploring the Relationship Between Brain Asymmetry and Attention TMS EEG, TMS fMRI - Normal Physiology | Not applicable | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 45 | 2019-02-28 | 2022-10-26 |
| Modulation of the Parieto-frontal Communication Transcranial Magnetic Stimulation (TMS), Working Memory Task - Normal Physiology | Not applicable | Withdrawn | National Institute of Neurological Disorders and Stroke (NINDS) | 2019-02-03 | 2019-02-28 | |
| Sociocultural & Biobehavioral Influences on Pain Expression and Assessment Medoc thermal stimulator, Electric shock stimulator, Cold water bath - Normal Physiology, Healthy Volunteers | Not applicable | Recruiting | National Center for Complementary and Integrative Health (NCCIH) | 700 | 2018-05-09 | 2026-10-20 |
| Development of Non-Invasive Brain Stimulation Techniques Sham TMS, TMS - Normal Physiology | Not applicable | Completed | National Institute of Mental Health (NIMH) | 85 | 2018-01-11 | 2026-10-01 |
| Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction In vivo MRS, fMRI, EEG/EOG - Normal Physiology | Not applicable | Completed | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 57 | 2016-06-28 | 2026-10-29 |
| Neural and Psychological Mechanisms of Pain Perception Instructions, Attention, Thermal Pain - Pain, Normal Physiology | Not applicable | Recruiting | National Center for Complementary and Integrative Health (NCCIH) | 550 | 2015-06-11 | 2026-11-09 |
| Energy Expenditure Responses to Different Temperatures Room temperatures - Obesity, Normal Physiology | Not applicable | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 104 | 2012-04-24 | 2026-08-27 |
| MRS Measurement of Glutamate and GABA Metabolism in Brain 3T and 7T device - Normal Physiology | Not applicable | Recruiting | National Institute of Mental Health (NIMH) | 200 | 2006-09-06 | 2026-11-12 |
Obesity (2) · Pain (2) · Attention Deficit Disorder with Hyperactivity (1) · Behavior (1) · Depressive Disorder, Major (1) · Fasting (1) · Substance-Related Disorders (1) · Weight Gain (1)
Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Body Weight (2) · Mental Disorders (2) · Neurologic Manifestations (2) · Nutrition Disorders (2) · Nutritional and Metabolic Diseases (2) · Overnutrition (2) · Overweight (2) · Attention Deficit and Disruptive Behavior Disorders (1) · Behavior (1) · Body Weight Changes (1) · Chemically-Induced Disorders (1) · Depressive Disorder (1) · Feeding Behavior (1)
Angptl4 protein, mouse (1) · Electroencephalography (1) · Neuropsychological Tests (1) · Nutritional Requirements (1) · Tobacco Use Cessation Devices (1) · Transcranial Magnetic Stimulation (1)
National Institute of Mental Health (NIMH) (4) · National Institute of Neurological Disorders and Stroke (NINDS) (4) · National Center for Complementary and Integrative Health (NCCIH) (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Massachusetts General Hospital (1) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1) · National Institute on Drug Abuse (NIDA) (1) · Sunnybrook Health Sciences Centre (1)
United States (15) · Canada (1)
Eric M Wassermann, M.D. (2) · Lauren Y Atlas, Ph.D. (2) · Alexander T Chesler, Ph.D. (1) · Allison C Nugent, Ph.D. (1) · Amy C Janes, Ph.D. (1) · Carlos A Zarate, M.D. (1) · Dardo G Tomasi, Ph.D. (1) · Elizabeth B Klerman, MD PhD (1) · Ellen Leibenluft, M.D. (1) · Fa-Hsuan Lin, PhD (1) · Kong Y Chen, Ph.D. (1) · Lauren B Reoma, M.D. (1) · Li An, Ph.D. (1) · Mark Hallett, M.D. (1) · Tomas Cabeza De Baca, Ph.D. (1)