16 completed, 2 active not recruiting, 2 terminated. 20 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 20 | Completed 16, Active not recruiting 2, Terminated 2 |
Follow Neurotoxicity: new trials by email Literature Review of Neurotoxicity trials Research Report on Neurotoxicity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Compare the Long-term Outcomes After Two Different Anaesthetics Sevoflurane, Remifentanil, Dexmedetomidine - Anesthesia, Neurotoxicity | Phase 3 | Active not recruiting | Murdoch Childrens Research Institute | 450 | 2017-08-10 | 2026-11-12 |
| Monosialotetrahexosylganglioside for Treatment of Oxaliplatin Induced Neurotoxicity in Gastrointestinal Cancer placebo, GM, oxaliplatin-based chemotherapy - Neurotoxicity | Phase 3 | Completed | Tianjin Medical University Cancer Institute and Hospital | 145 | 2015-05-05 | 2018-02-05 |
| Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery stereotactic radiosurgery, whole-brain radiation therapy - Cognitive/Functional Effects, Metastatic Cancer | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 194 | 2011-07-01 | 2022-09-16 |
| Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer bevacizumab, capecitabine, fluorouracil - Cognitive/Functional Effects, Colorectal Cancer | Phase 3 | Terminated | Alliance for Clinical Trials in Oncology | 32 | 2011-01-01 | 2017-12-08 |
| Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy calcium gluconate, magnesium sulfate, placebo - Chemotherapeutic Agent Toxicity, Colorectal Cancer | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 362 | 2010-06-01 | 2022-11-03 |
| Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma temozolomide, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy - Brain and Central Nervous System Tumors, Neurotoxicity | Phase 3 | Active not recruiting | Eastern Cooperative Oncology Group | 540 | 2009-11-17 | 2026-10-05 |
| S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, II, or IIIA Breast Cancer Undergoing Chemo acetyl-L-carnitine hydrochloride, placebo - Breast Cancer, Chemotherapeutic Agent Toxicity | Phase 3 | Completed | SWOG Cancer Research Network | 437 | 2009-09-01 | 2017-08-14 |
| Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer duloxetine hydrochloride, placebo - Neurotoxicity, Pain | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 231 | 2008-04-01 | 2017-04-26 |
| Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors Memantine, Placebo, Whole brain radiation therapy - Cognitive/Functional Effects, Metastatic Cancer | Phase 3 | Completed | Radiation Therapy Oncology Group | 554 | 2008-03-01 | 2017-08-21 |
| Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer baclofen/amitriptyline/ketamine gel, placebo - Chronic Myeloproliferative Disorders, Leukemia | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 208 | 2008-02-01 | 2017-08-24 |
| Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Cancer Patients ketamine/amitriptyline NP-H cream, placebo - Neurotoxicity, Pain | Phase 3 | Completed | Gary Morrow | 462 | 2007-10-01 | 2015-11-09 |
| Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer glutamic acid, placebo - Kidney Cancer, Leukemia | Phase 3 | Completed | University of South Florida | 250 | 2007-05-01 | 2021-08-11 |
| Alpha-Lipoic Acid in Preventing Peripheral Neuropathy in Patients Receiving Chemotherapy for Cancer alpha-lipoic acid, placebo - Neurotoxicity, Unspecified Adult Solid Tumor, Protocol Specific | Phase 3 | Completed | M.D. Anderson Cancer Center | 244 | 2007-01-01 | 2014-04-08 |
| Vitamin E in Preventing Peripheral Neuropathy Caused by Chemotherapy in Patients Receiving Chemotherapy for Cancer vitamin E, placebo - Neurotoxicity, Unspecified Adult Solid Tumor, Protocol Specific | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 207 | 2006-12-01 | 2016-07-06 |
| D-cycloserine in the Management of Chemotherapy-Induced Peripheral Neuropathic Pain D-cycloserine, Placebo - Neurotoxicity, Pain | Phase 3 | Terminated | Northwestern University | 7 | 2006-02-01 | 2013-12-02 |
| Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery calcium gluconate, magnesium sulfate, placebo - Colorectal Cancer, Neurotoxicity | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 104 | 2006-01-01 | 2016-08-11 |
| Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer lamotrigine, Placebo - Neurotoxicity, Pain | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 131 | 2004-02-01 | 2018-05-04 |
| Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer amifostine trihydrate - Gestational Trophoblastic Tumor, Neurotoxicity | Phase 3 | Completed | Gynecologic Oncology Group | 100 | 2003-03-01 | 2013-07-09 |
| EGb761 in Maintaining Mental Clarity in Women Receiving Chemotherapy for Newly Diagnosed Breast Cancer Ginkgo Biloba, Placebo - Breast Cancer, Neurotoxicity | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 226 | 2002-12-01 | 2016-07-06 |
| Gabapentin in Treating Peripheral Neuropathy in Cancer Patients Undergoing Chemotherapy gabapentin, placebo - Neurotoxicity, Pain | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 100 | 2002-02-01 | 2016-07-04 |
Neurotoxicity Syndromes (20) · Pain (6) · Peripheral Nervous System Diseases (4) · Brain Neoplasms (3) · Breast Neoplasms (3) · Colonic Neoplasms (3) · Colorectal Neoplasms (3) · Rectal Neoplasms (3) · Leukemia (2) · Lymphoma (2) · Neoplasm Metastasis (2) · Astrocytoma (1) · Burkitt Lymphoma (1) · Central Nervous System Neoplasms (1) · Dendritic Cell Sarcoma, Interdigitating (1)
Chemically-Induced Disorders (20) · Nervous System Diseases (20) · Poisoning (20) · Neoplasms (13) · Neoplasms by Site (11) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (7) · Neurologic Manifestations (6) · Digestive System Diseases (4) · Digestive System Neoplasms (4) · Gastrointestinal Diseases (4) · Neoplasms by Histologic Type (4) · Neuromuscular Diseases (4) · Brain Diseases (3) · Breast Diseases (3)
Oxaliplatin (3) · Calcium Gluconate (2) · Magnesium Sulfate (2) · Amifostine (1) · Baclofen (1) · Bevacizumab (1) · Capecitabine (1) · Cycloserine (1) · Dexmedetomidine (1) · Duloxetine Hydrochloride (1) · Fluorouracil (1) · Gabapentin (1) · Ginkgo Extract (1) · Glutamic Acid (1) · Ketamine (1)
Alliance for Clinical Trials in Oncology (10) · Eastern Cooperative Oncology Group (1) · Gary Morrow (1) · Gynecologic Oncology Group (1) · M.D. Anderson Cancer Center (1) · Murdoch Childrens Research Institute (1) · Northwestern University (1) · Radiation Therapy Oncology Group (1) · SWOG Cancer Research Network (1) · Tianjin Medical University Cancer Institute and Hospital (1) · University of South Florida (1)
United States (18) · Canada (2) · Australia (1) · China (1) · Italy (1) · Puerto Rico (1) · Spain (1)
Axel Grothey, MD (2) · Charles L. Loprinzi, MD (2) · Debra Barton, RN, PhD, AOCN, FAAN (2) · Paul D. Brown, MD (2) · Andrew J Davidson, MD (1) · Christina A. Meyers, PhD (1) · David R. Freyer, DO, MS (1) · David Schiff, MD (1) · Deepak Khuntia, MD (1) · Ellen L. Smith, PhD, ARNP, AOCN (1) · Eric Sandler, MD (1) · Jamie Von Roenn, MD (1) · Judith Paice, PhD, RN (1) · Laurence H. Baker, DO, FACOI (1) · Lisa Kottschade, RN, MSN, CNP (1)
PMID 17853395, PMID 18428211, PMID 20496177, PMID 20936417, PMID 21189381, PMID 21479990, PMID 23549581, PMID 23733756, PMID 23956241, PMID 24297951, PMID 24531792, PMID 26282635, PMID 26603828, PMID 28687377, PMID 28917648, PMID 34176021, PMID 34765950, PMID 36264568, PMID 36472389, PMID 38520467, PMID 39283983, PMID 42090240
U10CA037420 (1), U10CA037429 (1), U10CA045809 (1), U10CA081920 (1)