Radiation Therapy Oncology Group: Clinical Trials

191 trials sponsored by Radiation Therapy Oncology Group, newest first

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164 completed, 11 terminated, 7 active not recruiting, 5 unknown. 95 Phase 2, 79 Phase 3, 26 Phase 1, 8 Not applicable.

By phase and status

PhaseTrialsStatus
Phase 295Completed 84, Terminated 5, Withdrawn 3, Unknown 2, Active not recruiting 1
Phase 379Completed 67, Active not recruiting 5, Terminated 5, Unknown 2
Phase 126Completed 25, Withdrawn 1
Not applicable8Completed 6, Active not recruiting 1, Terminated 1

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Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

TrialPhaseStatusSponsorEnrollmentStartUpdated
Navigator-Assisted Hypofractionation (NAVAH) on Radiation Therapy Completion in Breast Cancer and Prostate Cancer
Pre & Post Surveys, Opt Out of Questionnaire - Breast Cancer, Prostate Cancer
RecruitingUniversity of Oklahoma4202025-10-162025-12-17
Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Limited Stage or Extensive Stage Small Cell Lung Cancer
Three-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy - Extensive Stage Small Cell Lung Carcinoma, Limited Stage Small Cell Lung Carcinoma
Phase 2 / Phase 3CompletedNRG Oncology4182015-12-222026-07-10
A Study of ABT-414 in Participants With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification
Temozolomide, Depatuxizumab mafodotin, Radiation - Glioblastoma, Gliosarcoma
Phase 3CompletedAbbVie6912015-01-042023-05-11
Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung Cancer
Carboplatin, Cisplatin, Durvalumab - Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7
Phase 3Active not recruitingRadiation Therapy Oncology Group3302014-01-032026-06-08
Radiation Therapy and Cisplatin With or Without Surgery in Treating Patients With Stage III-IV Oropharyngeal Cancer
therapeutic conventional surgery, intensity-modulated radiation therapy, cisplatin - Stage III Squamous Cell Carcinoma of the Oropharynx, Stage IVA Squamous Cell Carcinoma of the Oropharynx
Phase 2WithdrawnRadiation Therapy Oncology Group2013-12-012015-03-20
Soy Isoflavone in Combination With Radiation Therapy and Cisplatin in SCC of the Head and Neck
Soy isoflavone, Radiation, Cisplatin - Cancer of Head and Neck
Phase 1CompletedEmory University242013-11-012019-12-06
Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery
regional nodal XRT, chestwall XRT, WBI - Stage IB Breast Cancer, Stage II Breast Cancer
Not applicableActive not recruitingNSABP Foundation Inc16362013-08-012023-12-27
High or Standard Intensity Radiation Therapy After Gemcitabine Hydrochloride and Nab-paclitaxel in Treating Patients With Pancreatic Cancer That Cannot Be Removed by Surgery
low intensity radiation therapy, Capecitabine, Gemcitabine - Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer
Phase 2TerminatedRadiation Therapy Oncology Group202013-08-012018-07-13
Sorafenib Tosylate With or Without Stereotactic Body Radiation Therapy in Treating Patients With Liver Cancer
Sorafenib, stereotactic body radiation therapy - Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Phase 3CompletedRadiation Therapy Oncology Group1932013-04-012026-01-28
TRYHARD: Radiation Therapy Plus Cisplatin With or Without Lapatinib in Treating Patients With Head and Neck Cancer.
IMRT, Cisplatin, placebo - Non-HPV Locally Advanced Head and Neck Cancer
Phase 2CompletedRadiation Therapy Oncology Group1422013-03-152023-10-17
Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma
bevacizumab, radiation therapy - Adult Giant Cell Glioblastoma, Adult Glioblastoma
Phase 2CompletedRadiation Therapy Oncology Group1822012-12-202022-12-29
Radical Resection Vs. Ablative Stereotactic Radiotherapy in Patients With Operable Stage I NSCLC
Stereotactic Body Radiation Therapy (SBRT), Surgery - Non-small Cell Lung Cancer
Phase 2UnknownRadiation Therapy Oncology Group442012-12-012025-01-06
Standard Versus Intensity-Modulated Pelvic Radiation Therapy in Treating Patients With Endometrial or Cervical Cancer
Standard radiation therapy, intensity-modulated radiation therapy - Cervical Cancer, Endometrial Cancer
Phase 3CompletedRadiation Therapy Oncology Group2892012-11-012022-06-15
Cardiovascular Risk and Preventive Care in Prostate Cancer Patients Receiving Radiation and Hormone Therapy
Prostate Cancer
CompletedUNC Lineberger Comprehensive Cancer Center1012012-06-012018-08-14
Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer
GnRH agonist, Anti-androgen, TAK-700 - Prostate Cancer
Phase 3CompletedRadiation Therapy Oncology Group2392012-05-012026-03-06
Manuka Honey in Preventing Esophagitis-Related Pain in Patients Receiving Chemotherapy and Radiation Therapy For Lung Cancer
Manuka honey in liquid form, Manuka honey in lozenge form, Standard supportive care - Dysphagia, Lung Cancer
Phase 2CompletedRadiation Therapy Oncology Group1632012-02-012017-08-31
Ganitumab and Gemcitabine Hydrochloride Followed by Radiation Therapy, Ganitumab, Capecitabine, and Maintenance Therapy in Treating Patients With Locally Advanced Cancer of the Pancreas
ganitumab, capecitabine, gemcitabine hydrochloride - Pancreatic Cancer
Phase 1CompletedRadiation Therapy Oncology Group82012-02-012015-11-17
A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy Versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
Cisplatin: 40 mg/m2 weekly during radiation, Radiation: 60-66 Gy in 2 Gy daily fractions - Malignant Salivary Gland Tumors
Phase 2CompletedKing Faisal Specialist Hospital & Research Center1202011-11-012016-02-25
Natural History of Brain Function, Quality of Life, and Seizure Control in Patients With Brain Tumor Who Have Undergone Surgery
cognitive assessment, magnetic resonance imaging, laboratory biomarker analysis - Adult Diffuse Astrocytoma, Adult Mixed Glioma
CompletedRadiation Therapy Oncology Group822011-10-012015-03-18
Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma
Rituximab, Cytarabine, Methotrexate - Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects
Phase 2CompletedRadiation Therapy Oncology Group912011-09-012023-07-20

Showing 20 of 191. Sign in to see all of them.

Conditions studied

Prostatic Neoplasms (34)  ·  Lung Neoplasms (31)  ·  Carcinoma, Non-Small-Cell Lung (29)  ·  Head and Neck Neoplasms (28)  ·  Squamous Cell Carcinoma of Head and Neck (23)  ·  Glioblastoma (19)  ·  Central Nervous System Neoplasms (17)  ·  Gliosarcoma (16)  ·  Radiation Injuries (15)  ·  Brain Neoplasms (12)  ·  Breast Neoplasms (12)  ·  Neoplasm Metastasis (12)  ·  Adenocarcinoma of Lung (10)  ·  Astrocytoma (7)  ·  Glioma (7)

Interventions

Radiotherapy (91)  ·  Cisplatin (49)  ·  Paclitaxel (27)  ·  Radiotherapy, Intensity-Modulated (26)  ·  Radiotherapy, Conformal (22)  ·  Fluorouracil (19)  ·  Temozolomide (14)  ·  Brachytherapy (12)  ·  Carboplatin (12)  ·  Filgrastim (11)  ·  Flutamide (11)  ·  Gemcitabine (9)  ·  Gonadotropin-Releasing Hormone (9)  ·  Radiosurgery (9)  ·  bicalutamide (9)

Countries

United States (173)  ·  Canada (113)  ·  Israel (14)  ·  South Africa (8)  ·  Hong Kong (7)  ·  South Korea (7)  ·  Switzerland (5)  ·  Australia (4)  ·  China (4)  ·  Saudi Arabia (4)  ·  Singapore (4)  ·  Belgium (3)  ·  Ireland (3)  ·  Netherlands (3)  ·  France (2)

Top investigators

Jaffer A. Ajani, MD (5)  ·  Elizabeth M. Gore, MD (4)  ·  Jeffrey Bradley, MD (4)  ·  Al B. Benson, MD, FACP (3)  ·  Benjamin Movsas, MD (3)  ·  Burton L. Eisenberg, MD (3)  ·  Corey J. Langer, MD (3)  ·  Lawrence B. Berk, MD, PhD (3)  ·  Michael G. Haddock, MD (3)  ·  Minesh P. Mehta, MD (3)  ·  Mitchell Machtay, MD (3)  ·  Oliver Sartor, MD (3)  ·  Ritsuko U. Komaki, MD, FACR (3)  ·  Robert D. Timmerman, MD (3)  ·  Timothy J. Whelan, MD (3)

Results publications

PMID 38320143, PMID 31420360, PMID 36596347, PMID 41343184, PMID 25366678, PMID 30548235, PMID 36884035, PMID 36995690, PMID 37751207, PMID 10661346, PMID 10924966, PMID 11560968, PMID 11586105, PMID 11870157, PMID 11917283, PMID 12499279, PMID 12525193, PMID 12694838, PMID 12743142, PMID 12788192, PMID 14508838, PMID 14529764, PMID 14529772, PMID 14581419, PMID 14645636, PMID 14758134, PMID 14967428, PMID 15050309, PMID 15128893, PMID 15158627, PMID 15169799, PMID 15234047, PMID 15465203, PMID 15590164, PMID 15667949, PMID 15735120, PMID 15764775, PMID 15800308, PMID 15860857, PMID 15863167, PMID 15890570, PMID 15890573, PMID 15928300, PMID 15936549, PMID 15989995, PMID 16015544, PMID 16062084, PMID 16167048, PMID 16198508, PMID 16287132

NIH funding

U10CA021661 (18), U10CA180868 (7), U10CA032102 (3), 2015 (1), U10CA012027 (1), U10CA021115 (1), U10CA031946 (1), U10CA037422 (1), U10CA045809 (1), U10CA077202 (1), UG1CA189867 (1)