50 completed, 9 terminated, 7 unknown, 3 recruiting. 20 Phase 3, 16 Phase 2, 8 Not applicable, 6 Phase 4, 2 Early Phase 1.
Follow Neurotoxicity: new trials by email Literature Review of Neurotoxicity trials Research Report on Neurotoxicity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessing DCog Short for Neurotoxicity in CAR-T DCog Short - Neurotoxicity, Neurotoxicity Syndromes | Not applicable | Recruiting | Beth Israel Deaconess Medical Center | 40 | 2026-04-13 | 2026-10-08 |
| A Pilot Study for Pupillary Assessment to Predict CAR-T Related Neurotoxicity NeurOptics® NPi®-300 Pupillometer - Neurotoxicity | Recruiting | M.D. Anderson Cancer Center | 100 | 2024-02-08 | 2026-07-16 | |
| Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity exposure to organophosphates - Neuroinflammatory Response, Nerve Injury | Unknown | Alexandria University | 90 | 2023-08-01 | 2023-09-01 | |
| Effects of Lead Exposure on Ferroptosis Pathway Lead exposure - Lead Poisoning, Neurotoxicity | Unknown | Northern Jiangsu People's Hospital | 40 | 2023-07-01 | 2023-07-21 | |
| Electro-acupuncture for the Prevention and Treatment of Oxaliplatin-induced Neurotoxicity in Colorectal Cancer Patients Acupuncture, Sham-acupuncture - Colorectal Cancer, Oxaliplatin | Not applicable | Unknown | Hong Kong Baptist University | 150 | 2023-05-01 | 2023-04-05 |
| Tacrolimus Associated Tremors in Liver Transplantation: Immediate-Release Versus Extended-Release Formulations Tacrolimus, Immediate Release, Oral, Tacrolimus Extended Release Oral Tablet - Liver Transplantation, Immunosuppression | Phase 4 | Recruiting | University of British Columbia | 124 | 2023-01-09 | 2024-01-02 |
| Magnetic Resonance Imaging in Immune Effector Cell-Associated Neurotoxicity Syndrome Magnetic Resonance Imaging with contrast injection, Blood withdrawal, Neuropsychological tests - Lymphoma, B-Cell, Neurotoxicity | Not applicable | Completed | University Hospital, Montpellier | 25 | 2022-09-22 | 2024-08-09 |
| Effect of Antibiotic Choice On ReNal Outcomes (ACORN) anti-pseudomonal cephalosporin, anti-pseudomonal penicillin - Sepsis, AKI | Phase 4 | Completed | Vanderbilt University Medical Center | 2634 | 2021-11-10 | 2023-12-22 |
| Serum Neurofilament Light (NfL) as a Marker for Brain Injury in Individuals Undergoing Chimeric Antigen Receptor-modified T Therapy Neurotoxicity | Terminated | Washington University School of Medicine | 17 | 2021-02-25 | 2025-05-06 | |
| EEG Encephalopathy Patterns in Immune Effectors Cells-associated Neurotoxicity Syndrome (ICANS)Lay Language Immune Effector Cell Encephalopathy, Neurotoxicity | Completed | University Hospital, Montpellier | 40 | 2021-02-01 | 2022-04-12 | |
| A Phase 2 Trial of Anakinra for the Prevention of CAR-T Cell Mediated Neurotoxicity Anakinra, Axicabtagene Ciloleucel - Non Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma | Phase 2 | Completed | Marcela V. Maus, M.D.,Ph.D. | 15 | 2020-10-01 | 2025-11-25 |
| Envarsus Neurotoxicity Burden in Liver Transplant Patients Envarsus, Tacrolimus Immediate release - Neurotoxicity, Liver Transplant; Complications | Phase 4 | Completed | Medical University of South Carolina | 30 | 2020-01-31 | 2025-03-30 |
| o Tadalafil for Prevention of Docetaxel-Induced Peripheral Neuropathy in Prostate Cancer Tadalafil 5 mg - Prostate Cancer Metastatic Disease, Chemotherapy Induced Peripheral Neuropathy (CIPN) | Phase 2 | Completed | Tri-Service General Hospital (TSGH) | 90 | 2020-01-05 | 2026-01-12 |
| Effect of Tacrolimus Formulation on Neurological Side Effects in Older Kidney Transplant Recipients Envarsus, IR Tacrolimus - Kidney Transplant; Complications, Toxicity | Phase 4 | Completed | University of California, Davis | 64 | 2018-04-01 | 2025-04-08 |
| Clinical Trial of Electroacupuncture Stimulation on Prevention and Treatment of Oxaliplatin Neurotoxicity electro-acupuncture - Neurotoxicity, Gastrointestinal Neoplasms | Not applicable | Unknown | The First Affiliated Hospital of Dalian Medical University | 120 | 2017-09-01 | 2017-11-06 |
| A Study to Compare the Long-term Outcomes After Two Different Anaesthetics Sevoflurane, Remifentanil, Dexmedetomidine - Anesthesia, Neurotoxicity | Phase 3 | Active not recruiting | Murdoch Childrens Research Institute | 450 | 2017-08-10 | 2026-11-12 |
| Neurotoxicity Evaluation of Beta-lactams in Intensive Care Unit and Identification of the Risk Factors Neurotoxicity, Sepsis | Completed | Centre Hospitalier Universitaire, Amiens | 400 | 2017-01-01 | 2026-06-16 | |
| Enzymatic Evaluation of General Anesthetic Induced Neurotoxicity in Patients With Aneurysmal Subarachnoid Hemorrhage Anesthetic Agents - Neurotoxicity | Completed | Mukilan Balu | 32 | 2016-01-01 | 2017-09-19 | |
| Monosialoganglioside Preventing Neurotoxicity Induced by Albumin-bound Paclitaxel Chemotherapy in Lung Cancer Patients monosialoganglioside - Neurotoxicity | Phase 2 | Unknown | Peking University Cancer Hospital & Institute | 106 | 2015-07-01 | 2015-07-17 |
| Monosialotetrahexosylganglioside for Treatment of Oxaliplatin Induced Neurotoxicity in Gastrointestinal Cancer placebo, GM, oxaliplatin-based chemotherapy - Neurotoxicity | Phase 3 | Completed | Tianjin Medical University Cancer Institute and Hospital | 145 | 2015-05-05 | 2018-02-05 |
Showing 20 of 73. Sign in to see all of them.
Neurotoxicity Syndromes (73) · Peripheral Nervous System Diseases (10) · Pain (9) · Breast Neoplasms (8) · Lymphoma (7) · Central Nervous System Neoplasms (5) · Colorectal Neoplasms (5) · Ovarian Neoplasms (5) · Brain Neoplasms (4) · Carcinoma, Ovarian Epithelial (4) · Colonic Neoplasms (4) · Leukemia (4) · Radiation Injuries (4) · Rectal Neoplasms (4) · Astrocytoma (3)
Chemically-Induced Disorders (73) · Nervous System Diseases (73) · Poisoning (73) · Neoplasms (39) · Neoplasms by Site (29) · Pathological Conditions, Signs and Symptoms (23) · Neoplasms by Histologic Type (20) · Signs and Symptoms (16) · Neurologic Manifestations (13) · Hemic and Lymphatic Diseases (12) · Neuromuscular Diseases (11) · Immune System Diseases (10) · Immunoproliferative Disorders (10) · Female Urogenital Diseases and Pregnancy Complications (9) · Lymphatic Diseases (9)
Amifostine (4) · Oxaliplatin (4) · Radiotherapy (4) · Leucovorin (3) · Magnetic Resonance Spectroscopy (3) · Mental Status and Dementia Tests (3) · Methotrexate (3) · Paclitaxel (3) · Procarbazine (3) · Tacrolimus (3) · Vincristine (3) · Calcium Gluconate (2) · Carboplatin (2) · Cisplatin (2) · Cyclophosphamide (2)
Alliance for Clinical Trials in Oncology (11) · Case Comprehensive Cancer Center (3) · M.D. Anderson Cancer Center (3) · Radiation Therapy Oncology Group (3) · University of South Florida (3) · Children's Oncology Group (2) · Gynecologic Oncology Group (2) · Northwestern University (2) · University College, London (2) · University Hospital, Montpellier (2) · University of California, San Francisco (2) · Virginia Commonwealth University (2) · Alexandria University (1) · Beth Israel Deaconess Medical Center (1) · Centre Hospitalier Universitaire, Amiens (1)
United States (53) · Canada (6) · China (4) · France (4) · United Kingdom (3) · Australia (2) · Italy (2) · Egypt (1) · Hong Kong (1) · India (1) · Ireland (1) · Israel (1) · Puerto Rico (1) · Spain (1) · Switzerland (1)
Charles L. Loprinzi, MD (3) · Axel Grothey, MD (2) · Debra Barton, RN, PhD, AOCN, FAAN (2) · Paul D. Brown, MD (2) · Adam Glaser, MD (1) · Ali Choucair (1) · Alice Shapiro, PhD (1) · Andrew J Davidson, MD (1) · Andrew M. Evens, DO, MS (1) · Antonio Omuro, MD (1) · Armin Ghobadi, M.D. (1) · Arthur Forman, MD (1) · Bo Lu, MD, PhD (1) · Brigitte C. Widemann, MD (1) · Cataldo Doria, MD, PhD (1)
PMID 14615449, PMID 15494606, PMID 17853395, PMID 18428211, PMID 19546477, PMID 20496177, PMID 20936417, PMID 21189381, PMID 21383290, PMID 21479990, PMID 22415454, PMID 23549581, PMID 23733756, PMID 23956241, PMID 24297951, PMID 24531792, PMID 26282635, PMID 26603828, PMID 28687377, PMID 28917648, PMID 34176021, PMID 34765950, PMID 36264568, PMID 36307826, PMID 36472389, PMID 36898748, PMID 37837651, PMID 38520467, PMID 39283983, PMID 39928957, PMID 41089174, PMID 42090240
P30CA043703 (3), U10CA081920 (3), K12CA167540 (1), P30CA006927 (1), P30CA012197 (1), P30CA033572 (1), U10CA037420 (1), U10CA037422 (1), U10CA037429 (1), U10CA045809 (1)