Neurotoxicity Syndromes: Clinical Trials

109 completed, 30 unknown, 20 terminated, 14 recruiting. 42 Phase 2, 41 Phase 3, 36 Not applicable, 15 Phase 1, 13 Phase 4.

By phase and status

Phase	Trials	Status
Phase 2	42	Completed 23, Terminated 9, Unknown 6, Withdrawn 2, Active not recruiting 1, Recruiting 1
Phase 3	41	Completed 24, Unknown 5, Terminated 4, Withdrawn 3, Active not recruiting 2, Enrolling by invitation 1, Recruiting 1, Suspended 1
Not applicable	36	Completed 18, Recruiting 5, Unknown 4, Active not recruiting 3, Terminated 3, Withdrawn 2, Not yet recruiting 1
Phase 1	15	Completed 10, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Terminated 1, Unknown 1
Phase 4	13	Completed 5, Unknown 4, Terminated 2, Enrolling by invitation 1, Recruiting 1
Early Phase 1	3	Active not recruiting 1, Completed 1, Withdrawn 1

Follow Neurotoxicity Syndromes: new trials by email Literature Review of Neurotoxicity Syndromes trials Research Report on Neurotoxicity Syndromes

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Safety and Tolerability of Single and Repeated Dose of IMM02-KORA in PD-associated Dyskinesia IMM02-KORA - Dyskinesia, Medication-induced, Dyskinesia, Drug-Induced	Phase 1	Not yet recruiting	Immunis, Inc.	15	2026-11-30	2026-10-30
Preventox - a Digital Intervention for Patients With Intoxications in Intensive Care Preventox, a digital self-help tool for patients with intoxications in intensive care., Preventox control group - Intoxication, Delirium Tremens (DTs)	Not applicable	Not yet recruiting	Karolinska Institutet	50	2026-09-30	2026-09-23
Delayed Toxicities Post-CAR-T Multiple Myeloma		Recruiting	Icahn School of Medicine at Mount Sinai	30	2026-07-10	2026-08-10
A Computer-Assisted Tool for Objective Assessment of Extrapyramidal Symptoms Computer-Assisted Objective Assessment of Extrapyramidal Symptoms - Extrapyramidal Symptoms, Drug-induced Parkinsonism		Not yet recruiting	Shanghai Mental Health Center	180	2026-07-01	2026-07-21
Assessing DCog Short for Neurotoxicity in CAR-T DCog Short - Neurotoxicity, Neurotoxicity Syndromes	Not applicable	Recruiting	Beth Israel Deaconess Medical Center	40	2026-04-13	2026-10-08
Atamparib in Patients With Advanced Solid Tumors atamparib escalation levels, atamparib RP2D - NSCLC Adenocarcinoma, Solid Tumor	Phase 1 / Phase 2	Recruiting	Nerviano Medical Sciences (Shanghai) Ltd.	178	2026-03-18	2026-07-29
Table-Top Water Pitcher to Reduce Arsenic Exposure Among Well Users in New Hampshire Water Pitcher Filtration System - Arsenic Poisoning, Environmental Exposure	Not applicable	Active not recruiting	Trustees of Dartmouth College	25	2026-02-24	2026-09-28
Nerve Excitability in Cisplatin-Induced Peripheral Neuropathy Threshold Tracking Nerve Conduction Studies - Peripheral Neuropathy Due to Chemotherapy, Peripheral Neuropathy	Not applicable	Recruiting	Ka-Wai Ho	60	2026-01-31	2026-04-22
Non-Pharmacological Interventions for Neurotoxicity in Hematologic Patients Receiving CAR-T Therapy Physical activity, Physical activity and nutrition - Hematologic Cancer	Not applicable	Recruiting	Instituto de Investigacion Sanitaria INCLIVA	338	2025-09-30	2026-07-28
Microbiome Determinants of Adverse Effects of Stereotactic Radiosurgery Adverse Radiation Effects, Radiation Necrosis		Recruiting	University of Chicago	150	2025-08-05	2026-08-18
Evaluating Cognitive Changes on Patients in Chemotherapy (ECCPC) Low-Intensity Walking Intervention, Control Group Intervention - Chemotherapy-related Cognitive Impairment	Phase 3	Enrolling by invitation	Ellis Medicine	100	2025-06-09	2025-08-12
Effects of Thoracolumbar Stabilization Versus Spinal Decompression Exercises on Maigne's Syndrome Lumbothoracic stabilization exercises, Spinal decompression exercises, Standardized physical therapy treatment - Syndrome, Manganese Neurotoxicity	Not applicable	Completed	Riphah International University	26	2025-01-01	2026-02-23
Extracellular Vesicles and Chemotherapy-Induced Peripheral Neuropathy CIPN assessment, EV blood analysis - Chemotherapy-Induced Peripheral Neuropathy, Breast Cancer	Not applicable	Recruiting	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico	120	2025-01-01	2026-04-30
rTMS as an Intervention for Levodopa-induced Dyskinesia active TMS, sham TMS - Dyskinesia, Drug-Induced, Parkinson Disease	Not applicable	Recruiting	Danish Research Centre for Magnetic Resonance	68	2024-08-22	2026-08-27
ADC-induced Neurotoxicity Treated With Duloxetine duloxetine - Solid Tumour	Phase 2	Unknown	Fudan University	37	2024-08-06	2024-09-19
Study of the Drug B11-FC (Botulism Treatment) B11-FC, Botulinum neurotoxin type A, Placebo - Botulism	Phase 1 / Phase 2	Unknown	Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation	40	2024-08-01	2024-08-30
Tolerability and Immunogenicity of a Single 40-ug Dose of rBV A/B for the Production of BabyBIG® rBV A/B - Botulism	Phase 2	Completed	California Department of Public Health	25	2024-07-09	2026-07-30
A Pilot Study for Pupillary Assessment to Predict CAR-T Related Neurotoxicity NeurOptics® NPi®-300 Pupillometer - Neurotoxicity		Recruiting	M.D. Anderson Cancer Center	100	2024-02-08	2026-07-16
Effect of Amifampridine on Neuromuscular Transmission in Patients Treated With OnabotulinumtoxinA Amifampridine - Botulism, Iatrogenic Botulism	Phase 1	Completed	Wake Forest University Health Sciences	21	2023-09-15	2025-02-03
Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis Botulinum toxin, Standard-of-care corticosteroid injections - Carpometacarpal Sprain, Thumb Sprain	Phase 3	Recruiting	Rhode Island Hospital	50	2023-08-27	2024-11-20

Showing 20 of 199. Sign in to see all of them.

Narrower conditions

Botulism (19)  ·  Dyskinesia, Drug-Induced (17)  ·  Breast Neoplasms (13)  ·  Peripheral Nervous System Diseases (13)  ·  Pain (12)  ·  Parkinson Disease (12)  ·  Alcohol Withdrawal Delirium (11)  ·  Ovarian Neoplasms (10)  ·  Colorectal Neoplasms (9)  ·  Lymphoma (9)  ·  Dyskinesias (7)  ·  Leukemia (7)  ·  Alcoholism (6)  ·  Brain Neoplasms (6)

Broader conditions

Chemically-Induced Disorders (199)  ·  Nervous System Diseases (198)  ·  Poisoning (197)  ·  Neoplasms (67)  ·  Pathological Conditions, Signs and Symptoms (65)  ·  Neoplasms by Site (53)  ·  Signs and Symptoms (53)  ·  Neurologic Manifestations (48)  ·  Neuromuscular Diseases (35)  ·  Central Nervous System Diseases (31)  ·  Neoplasms by Histologic Type (31)  ·  Brain Diseases (26)  ·  Infections (26)  ·  Hemic and Lymphatic Diseases (22)

Interventions

Paclitaxel (8)  ·  Oxaliplatin (6)  ·  Carboplatin (5)  ·  Amifostine (4)  ·  Dexmedetomidine (4)  ·  Leucovorin (4)  ·  Mental Status and Dementia Tests (4)  ·  Radiotherapy (4)  ·  Vincristine (4)  ·  Baclofen (3)  ·  Botulinum Antitoxin (3)  ·  Cisplatin (3)  ·  Cyclophosphamide (3)  ·  Cytarabine (3)  ·  Fluorouracil (3)

Sponsors

Alliance for Clinical Trials in Oncology (12)  ·  Gynecologic Oncology Group (6)  ·  National Cancer Institute (NCI) (5)  ·  M.D. Anderson Cancer Center (4)  ·  California Department of Public Health (3)  ·  Case Comprehensive Cancer Center (3)  ·  Children's Oncology Group (3)  ·  National Institute of Allergy and Infectious Diseases (NIAID) (3)  ·  Radiation Therapy Oncology Group (3)  ·  Tianjin Medical University Cancer Institute and Hospital (3)  ·  University Hospital, Montpellier (3)  ·  University of South Florida (3)  ·  Addex Pharma S.A. (2)  ·  Centre Hospitalier Universitaire, Amiens (2)  ·  Chang Gung Memorial Hospital (2)

Countries

United States (102)  ·  China (14)  ·  France (13)  ·  Canada (12)  ·  Italy (7)  ·  Taiwan (7)  ·  Spain (6)  ·  Australia (5)  ·  Egypt (4)  ·  Germany (4)  ·  United Kingdom (4)  ·  Denmark (3)  ·  Switzerland (3)  ·  Bangladesh (2)  ·  Belgium (2)

Top investigators

Charles L. Loprinzi, MD (3)  ·  Yi Ba, MD.PHD (3)  ·  Axel Grothey, MD (2)  ·  Debra Barton, RN, PhD, AOCN, FAAN (2)  ·  Paul D. Brown, MD (2)  ·  Subsai Kongsaengdao, M.D. (2)  ·  Adam Glaser, MD (1)  ·  Adrian Newman-Tancredi, PhD (1)  ·  Albert Vandenberg, PhD (1)  ·  Ali Choucair (1)  ·  Alice Shapiro, PhD (1)  ·  Amr M Yassen, MD (1)  ·  Andrew J Davidson, MD (1)  ·  Andrew M. Evens, DO, MS (1)

Results publications

PMID 30679026, PMID 31378656, PMID 36606664, PMID 10366002, PMID 10400452, PMID 14615449, PMID 15277925, PMID 15494606, PMID 15502041, PMID 16369168, PMID 17051488, PMID 17761724, PMID 17853395, PMID 18428211, PMID 18946287, PMID 19220084, PMID 19546477, PMID 20171695, PMID 20496177, PMID 20936417, PMID 20944765, PMID 20951277, PMID 20962652, PMID 20970173, PMID 21189381, PMID 21383290, PMID 21479990, PMID 21996132, PMID 22192096, PMID 22415454, PMID 22898443, PMID 23159589, PMID 23165399, PMID 23246491, PMID 23387558, PMID 23535829, PMID 23549581, PMID 23733756, PMID 23956241, PMID 23994303, PMID 24007658, PMID 24297951, PMID 24355920, PMID 24531792, PMID 24582486, PMID 24657098, PMID 24742381, PMID 25625990, PMID 26052727, PMID 26282635

NIH funding

P30CA043703 (3), U10CA081920 (3), U10CA027469 (2), U10CA101165 (2), 2005 (1), 2008 (1), 2019 (1), 2025 (1), K12CA120780 (1), K12CA167540 (1), P30CA006927 (1), P30CA012197 (1), P30CA016520 (1), P30CA033572 (1), R01ES019841 (1)