7 completed, 4 recruiting, 3 not yet recruiting, 1 active not recruiting. 6 Not applicable, 4 Phase 2, 3 Phase 4, 2 Phase 3, 1 Early Phase 1.
Follow Neurogenic Orthostatic Hypotension: new trials by email Literature Review of Neurogenic Orthostatic Hypotension trials Research Report on Neurogenic Orthostatic Hypotension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Spinal Cord Stimulation for Neurogenic Orthostatic Hypotension Lower thoracic epidural spinal cord stimulation - Neurogenic Orthostatic Hypotension | Not applicable | Not yet recruiting | Aerospace Center Hospital | 20 | 2026-12-01 | 2026-10-16 |
| Artificial Intelligence-based Parkinson's Disease Risk Assessment (AI-PRA) Study Smartwatch and phone app - Parkinson Disease (PD), REM Sleep Behavior Disorder (iRBD) | Not yet recruiting | Queen Mary University of London | 60 | 2026-10-01 | 2026-10-02 | |
| A Study in Subjects With Neurogenic Orthostatic Hypotension CST-3056, Placebo - Neurogenic Orthostatic Hypotension | Phase 2 | Active not recruiting | CuraSen Therapeutics, Inc. | 12 | 2025-09-12 | 2026-10-22 |
| Controlled CO2 Inhalation in NOH Controlled CO2 delivery, Controlled CO2 delivery (Sham) - Neurogenic Orthostatic Hypotension | Not applicable | Not yet recruiting | University of Calgary | 28 | 2025-05-01 | 2024-12-30 |
| CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study CO2 ReHaler - Neurogenic Orthostatic Hypotension, Autonomic Failure | Not applicable | Recruiting | University of Calgary | 28 | 2024-07-30 | 2026-05-05 |
| Sinusoidal Galvanic Vestibular Stimulation for Neurogenic Orthostatic Hypotension / Syncope Sinosuidal Galvanic Vestibular Stimulation, Placebo - Neurogenic Orthostatic Hypotension | Not applicable | Withdrawn | Hackensack Meridian Health | 2023-01-01 | 2022-12-16 | |
| CPAP for the Treatment of Supine Hypertension Active CPAP, Sham CPAP, Sleeping in a head-up tilt (HUT) position - Autonomic Failure, Pure Autonomic Failure | Not applicable | Recruiting | Vanderbilt University Medical Center | 59 | 2022-06-23 | 2026-04-07 |
| Hypercapnia in Orthostatic Hypotension Sequential Gas Delivery - Orthostatic Hypotension, Neurogenic Orthostatic Hypotension | Not applicable | Recruiting | University of Calgary | 80 | 2022-03-01 | 2026-05-05 |
| Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients Midodrine, Placebo pill, Abdominal compression - Neurogenic Orthostatic Hypotension, Autonomic Failure | Early Phase 1 | Completed | Vanderbilt University Medical Center | 31 | 2020-11-09 | 2026-08-07 |
| Efficacy and Tolerance of Flucortac in Patients With Orthostatic Neurogenic Hypotension Fludrocortisone, Placebo - Neurogenic Orthostatic Hypotension | Phase 4 | Unknown | H.A.C. PHARMA | 90 | 2020-07-09 | 2023-10-02 |
| Brain Perfusion & Oxygenation in Parkinson's Disease With NOH Droxidopa, Placebo - Parkinson Disease, Neurogenic Orthostatic Hypotension | Phase 4 | Completed | William Ondo, MD | 17 | 2018-08-23 | 2022-09-06 |
| Efficacy and Safety of Midodrine and Atomoxetine for Neurogenic OH Midodrine, Atomoxetine - Neurogenic Orthostatic Hypotension | Phase 4 | Completed | Seoul National University Hospital | 50 | 2018-01-01 | 2019-04-05 |
| TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) TD-9855, Placebo - Neurogenic Orthostatic Hypotension, Multiple System Atrophy (MSA) With Orthostatic Hypotension | Phase 2 | Completed | Theravance Biopharma | 34 | 2017-09-09 | 2022-09-26 |
| Norepinephrine Transporter Blockade, Autonomic Failure (NETAF) Atomoxetine, Placebo - Neurogenic Orthostatic Hypotension | Phase 2 | Completed | Vanderbilt University Medical Center | 48 | 2016-08-29 | 2023-09-13 |
| Natural History Study of Synucleinopathies Patients With Synucleinopathies, Neurogenic Orthostatic Hypotension | Recruiting | NYU Langone Health | 800 | 2011-06-01 | 2026-06-10 | |
| Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome Droxidopa - Chronic Fatigue Syndrome, Orthostatic Hypotension | Phase 2 | Terminated | Chelsea Therapeutics | 3 | 2010-07-01 | 2014-06-09 |
| Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304) Droxidopa - Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency | Phase 3 | Completed | Chelsea Therapeutics | 350 | 2009-01-01 | 2024-02-09 |
| Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Droxidopa, Placebo - Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy | Phase 3 | Completed | Chelsea Therapeutics | 103 | 2008-01-01 | 2014-05-16 |
Hypotension, Orthostatic (6) · Parkinson Disease (6) · Pure Autonomic Failure (6) · Multiple System Atrophy (5) · REM Sleep Behavior Disorder (2) · dopamine beta hydroxylase deficiency (2) · Anosmia (1) · Fatigue Syndrome, Chronic (1) · Hypertension (1) · Lewy Body Disease (1) · Multiple system atrophy (MSA) with orthostatic hypotension (1)
Nervous System Diseases (11) · Autonomic Nervous System Diseases (9) · Primary Dysautonomias (9) · Basal Ganglia Diseases (7) · Brain Diseases (7) · Central Nervous System Diseases (7) · Movement Disorders (7) · Neurodegenerative Diseases (7) · Synucleinopathies (7) · Cardiovascular Diseases (6) · Hypotension (6) · Orthostatic Intolerance (6) · Parkinsonian Disorders (6) · Vascular Diseases (6) · Mental Disorders (2)
Droxidopa (4) · 3,4-dihydroxyphenylserine aldolase (2) · Atomoxetine Hydrochloride (2) · Midodrine (2) · Sugars (2) · Fludrocortisone (1) · Patient Positioning (1) · Sleep (1) · ampreloxetine (1)
Chelsea Therapeutics (3) · University of Calgary (3) · Vanderbilt University Medical Center (3) · Aerospace Center Hospital (1) · CuraSen Therapeutics, Inc. (1) · H.A.C. PHARMA (1) · Hackensack Meridian Health (1) · NYU Langone Health (1) · Queen Mary University of London (1) · Seoul National University Hospital (1) · Theravance Biopharma (1) · William Ondo, MD (1)
United States (10) · Canada (4) · France (2) · South Korea (2) · Spain (2) · Argentina (1) · Australia (1) · New Zealand (1) · United Kingdom (1)
Horacio Kaufmann, MD (2) · Satish R Raj, MD (2) · Charles W Lapp, M.D. (1) · Christopher J. Mathias, MD (1) · Chu Kon (1) · Cyndya A Shibao, MD (1) · Horacio C Kaufmann, MD (1) · Horacio Kaufmann Kaufmann, MD (1) · Italo Biaggioni, MD (1) · Luis Okamoto, MD (1) · Martin Gizzi, MD (1) · William Ondo, MD (1)
PMID 29405350, PMID 33554315, PMID 33782836, PMID 34657222, PMID 41734601
2018 (1), R01HL144568 (1), R01HL161095 (1)