20 unknown, 15 completed, 2 enrolling by invitation, 2 not yet recruiting. 30 Not applicable, 4 Phase 2, 3 Phase 3, 3 Phase 4, 2 Early Phase 1.
Follow Necrotic Pulp: new trials by email Literature Review of Necrotic Pulp trials Research Report on Necrotic Pulp
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Post-operative Pain and Levels of MMP -9 Following Root Canal Irrigation With Sodium Hypochlorite Versus Cold Atmospheric Plasma in Patient With Necrotic Single Rooted Teeth: Randomized Clinical Trial Application of cold atmospheric plasma - Necrotic Pulp | Not applicable | Not yet recruiting | Ahmed Hesham Abdelmohaimen Rezk | 60 | 2026-08-01 | 2026-08-05 |
| Evaluation of Pain Relief and Bacterial Reduction After Using Calcium Hydroxide With Mesoporous Silica Nanoparticles as an Intracanal Medicament in Necrotic Mandibular Molars: A Randomized Controlled Clinical Trial Calcium Hydroxide Intracanal medication, mesoporous silica nanoparticles paste, Calcium Hydroxide + mesoporous silica nanoparticles - Necrotic Pulp | Not applicable | Active not recruiting | Future University in Egypt | 42 | 2025-09-01 | 2026-01-08 |
| Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol, Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles, chitosan-coated silver nanoparticles - Pain, Postoperative, Root Resorption | Not applicable | Enrolling by invitation | Ain Shams University | 108 | 2025-07-01 | 2026-09-29 |
| Maximum Occlusal Bite Force of Necrotic Permanent Teeth Treated by Regenerative Technique: Randomized Clinical Trial measurement of maximum bite force using bite fork, conventional root canal treatment, pulp revascularization by induced bleeding - Necrotic Pulp, Regenerative Endodontic Procedures | Not applicable | Enrolling by invitation | Lama Awawdeh | 40 | 2024-12-20 | 2025-04-18 |
| Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing aPDT - Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp | Not applicable | Completed | Saglik Bilimleri Universitesi | 20 | 2024-10-21 | 2025-04-17 |
| Evaluation of Postoperative Pain and Success Rate Between Lateral Condensation and Warm Vertical Obturation Techniques Warm Vertical Condensation (WVO), Cold Lateral Condensation (CLC) - Necrotic Pulp, Asymptomatic Apical Periodontitis | Not applicable | Recruiting | University of Jordan | 80 | 2024-10-17 | 2026-04-02 |
| Efficacy of Integrated Nano-technology in Revascularization of Immature Necrotic Teeth regenerative endodontic procedure using blood clot according to AAE, regenerative endodontic procedure using photo activated nanochitosan 2% - Immature Teeth, Necrotic Pulp | Not applicable | Not yet recruiting | Minia University | 20 | 2024-10-11 | 2024-10-08 |
| Effect of Commiphora Myrrh Solution as a Root Canal Irrigant on Post Operative Pain and Bacterial Load Reduction in Necrotic Tooth Root canal irrigant Commiphora Myrrh 50% - Necrotic Pulp | Not applicable | Unknown | Cairo University | 42 | 2024-05-01 | 2024-03-13 |
| Clinical Efficacy of Novel Jasminum-based Calcium Hydroxide Medicament Nano-reinforced calcium hydroxide medicament, Calcium hydroxide without nanoparicles - Necrotic Pulp, Acute Apical Periodontitis of Pulpal Origin | Not applicable | Completed | Pakistan Institute of Medical Sciences | 60 | 2024-04-24 | 2024-10-30 |
| Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial RVS, L-PRF, i-PRF - Necrotic Pulp, Regenerative Endodontic Procedures | Not applicable | Completed | Saglik Bilimleri Universitesi | 48 | 2024-02-03 | 2025-03-20 |
| Clinical and Radiographic Evaluation of Zinc Oxide Modified 3Mixtatin Versus Zical in Root Canal Treatment of Necrotic Primary Molars. Group( 1): Control Group (pulpectomy using zic oxide eugenol based sealer Zical):, Group ( 2) Experimental group modified 3-MIX-TATIN): - Necrotic Pulp, Primary Teeth | Not applicable | Unknown | Ain Shams University | 34 | 2024-01-01 | 2024-12-31 |
| Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic Pulp Vachellia Nelotica, sodium hypochlorite - Necrotic Pulp, Post Operative Pain | Phase 4 | Unknown | Cairo University | 46 | 2023-11-01 | 2023-11-03 |
| Effect of Epigallocatechin-3-Gallate Solution as a Root Canal Irrigant on Post-Operative Pain Intensity and Bacterial Load Reduction in Necrotic Tooth Epigallocatechin-3-gallate, sodium hypochlorite - Necrotic Pulp | Not applicable | Completed | Cairo University | 40 | 2023-10-01 | 2025-01-10 |
| Efficacy of Guedes-Pinto Paste and CTZ Paste in the Non-instrumental Endodontic Treatment of Primary Teeth Irrigation, Filling with Guedes-Pinto Paste, Filling with CTZ Paste - Necrotic Pulp | Phase 1 / Phase 2 | Unknown | University of Nove de Julho | 120 | 2023-08-20 | 2023-05-17 |
| Effect of Apical Enlargement to Different Preparation Sizes and Tapers on Pain and Bacterial Reduction in Necrotic Pulp Root canal instrumentation EdgeFile X7 to size #35/0.06, Root canal instrumentation EdgeFile X7 to size #45/0.04, Root canal instrumentation EdgeFile X7 to size #45/0.06 - Necrotic Pulp | Not applicable | Unknown | Cairo University | 56 | 2023-01-01 | 2022-11-21 |
| Mechanical Vs Chemomechanical Method For Calcium Hydroxide Removal Mechanical Method, Chemomechanical Method - Necrotic Pulp, Chronic Apical Periodontitis | Not applicable | Completed | Pakistan Institute of Medical Sciences | 60 | 2022-12-16 | 2023-09-21 |
| Effect of Diclofenac Sodium Versus Calcium Hydroxide as Intracanal Medication on the Intensity of Postoperative Pain, Bacterial Load Reduction and MMP-9 Levels in Patients With Necrotic Pulp. Diclofenac Sodium - Necrotic Pulp, Apical Periodontitis | Early Phase 1 | Unknown | Cairo University | 30 | 2022-12-01 | 2022-11-10 |
| Bacterial Reduction of Rotary Versus Manual Filing System Using Different Irrigants in Primary Molars manual saline IA, manual neem IB, manual sodium hypochlorite IC - Necrotic Pulp | Not applicable | Completed | Mansoura University | 30 | 2022-09-12 | 2024-05-29 |
| Concentrated Growth Factor Versus Platelet Rich Fibrin in Revitalization of Necrotic Young Permanent Incisors revitalization by concentrated growth factor - Necrotic Pulp | Not applicable | Unknown | Ahmad Elheeny | 60 | 2022-09-01 | 2022-08-31 |
| Effect of Moringa Oleifera Leaf Extract on Postoperative Pain and Bacterial Reduction in Mandibular Premolars Moringa oleifera leaf, Sodium hypochlorite - Necrotic Pulp | Phase 2 / Phase 3 | Unknown | Cairo University | 30 | 2022-08-01 | 2022-08-09 |
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Dental Pulp Necrosis (41) · Pain, Postoperative (10) · Periapical Periodontitis (7) · Acute Pain (1) · Diabetes Mellitus, Type 2 (1) · Infections (1) · Necrosis (1) · Persistent Infection (1) · Pulpitis (1) · Root Resorption (1) · Tooth Discoloration (1)
Dental Pulp Diseases (41) · Pathologic Processes (41) · Pathological Conditions, Signs and Symptoms (41) · Stomatognathic Diseases (41) · Tooth Diseases (41) · Necrosis (40) · Neurologic Manifestations (11) · Pain (11) · Signs and Symptoms (11) · Postoperative Complications (10) · Jaw Diseases (7) · Mouth Diseases (7) · Periapical Diseases (7) · Periodontal Diseases (7) · Periodontitis (7)
Sodium Hypochlorite (7) · Calcium Hydroxide (4) · Apexification (1) · Chlorhexidine (1) · Ciprofloxacin (1) · Diclofenac (1) · EndoSequence root repair material (1) · Etidronic Acid (1) · Lasers (1) · MTAD (intracanal irrigant) (1) · Metapex (1) · Oils, Volatile (1) · Ointments (1) · Pemetrexed (1) · Population Groups (1)
Cairo University (19) · Ain Shams University (3) · Bulent Ecevit University (2) · Mansoura University (2) · Pakistan Institute of Medical Sciences (2) · Saglik Bilimleri Universitesi (2) · Ahmad Elheeny (1) · Ahmed Hesham Abdelmohaimen Rezk (1) · Alexandria University (1) · Enas Ebrahim Sayed (1) · Future University in Egypt (1) · Lama Awawdeh (1) · Mahmoud M Saadoon (1) · Minia University (1) · University of Belgrade (1)
Egypt (13) · Turkey (Türkiye) (4) · Jordan (2) · Pakistan (2) · Serbia (1)
Nehal Amir, BDS (2) · Amatallah HN Al-Rawhani, Master (1) · Ashraf Y Alhsoainy, PhD (1) · Dejan Markovic, Professor (1) · Geraldine M. Ahmed, ass. professor (1) · Gozlan FS Mohamed (1) · Heba El-Asfouri, Ph.D. (1) · Hulde Korucu, DDS (1) · Ibrahim H Elkalla, PhD (1) · Jealane El-Shafei, PhD (1) · Laila Z Ismail, M.Sc. (1) · Maged M Negm, Ph.D. (1) · Marwa A Abozed, BDSC (1) · Michel K Elias, M.Sc. (1) · Mohamed A Asal, MDS (1)
PMID 25069909, PMID 25443280, PMID 31155298, PMID 34826060, PMID 37682887, PMID 39407365, PMID 39789544, PMID 40466913