24 completed, 3 terminated, 2 withdrawn, 1 active not recruiting. 14 Not applicable, 9 Phase 3, 4 Phase 4, 2 Phase 1, 2 Phase 2.
Follow Nasal Congestion: new trials by email Literature Review of Nasal Congestion trials Research Report on Nasal Congestion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers Quinton Medical Nasal Health Baby® - Nasal Congestion, Common Cold | Not yet recruiting | Laboratoires Quinton International S.L. | 83 | 2026-11-01 | 2026-10-13 | |
| Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in Adults dipyrone monohydrate 1000 mg + chlorpheniramine maleate 4 mg + caffeine 60 mg, dipyrone monohydrate 500 mg + chlorpheniramine maleate 2 mg + caffeine 30 mg, Placebo - Common Cold/Flu, Nasal Congestion | Phase 3 | Recruiting | Brainfarma Industria Química e Farmacêutica S/A | 620 | 2026-05-08 | 2026-06-16 |
| Laser Posterior Nasal Nerve Neurolysis Laser posterior nasal nerve neurolysis, Sham surgery - Allergic Rhinitis, Chronic Rhinitis | Not applicable | Active not recruiting | Chiayi Christian Hospital | 120 | 2024-11-01 | 2025-12-17 |
| Efficacy and Safety of Auricular Acupressure in Treating Allergic Rhinitis Auricular acupressure, Sham acupressure, Standard treatment - Itching, Runny Nose | Not applicable | Completed | University of Medicine and Pharmacy at Ho Chi Minh City | 90 | 2024-03-13 | 2024-10-29 |
| Sonu Real-World Use Clinical Study to Treat Moderate to Severe Nasal Congestion Sonu Acoustic Resonance Therapy - Nasal Congestion | Not applicable | Terminated | Third Wave Therapeutics | 121 | 2023-08-08 | 2025-01-01 |
| PMCF Study to Evaluate Performance and Safety of "NASAL SPRAYS " Used to Relieve Nasal Congestion and Dryness Nasal sprays with sea salts - Nasal Congestion, Nasal Dryness | Not applicable | Completed | C.O.C. Farmaceutici S.r.l. | 105 | 2022-09-01 | 2024-03-27 |
| A Nasal Spray for Relief of Nasal Congestion in Infants and Toddlers With Common Cold Blocked Nose Baby nasal spray, Standard of care - Nasal Congestion | Not applicable | Completed | Church & Dwight Company, Inc. | 220 | 2022-01-20 | 2023-10-26 |
| Effects of Different Nasal Irrigation Methods on Pain Level, Crying and Procedure Times in Nasal Congestion in Infants Nasal irrigation with isotonic saline, Nasal irrigation with hypertonic saline, Nontraumatic nasopharyngeal aspiration - Nasal Congestion, Nursing | Not applicable | Completed | Istanbul Medeniyet University | 126 | 2022-01-03 | 2024-11-15 |
| Two Seawater-based Formulations for Relief of Nasal Congestion in Paediatric Subjects IP1 - Stérimar BLOCKED NOSE Baby nasal spray, IP2 - Stérimar Stop & Protect Cold Baby + standard of care, Standard of Care - Common Cold, Nasal Congestion | Not applicable | Terminated | Church & Dwight Company, Inc. | 9 | 2021-11-25 | 2024-10-03 |
| Efficacy and Safety of Azeol Nasal Spray Versus Placebo in the Treatment of Early Symptoms of Common Cold in Adults Azeol spray nasal, Placebo nasal spray - Nasal Congestion | Not applicable | Completed | Larena SAS | 144 | 2021-11-22 | 2023-11-14 |
| Implementation of a Minor Ailment Service in Community Pharmacy Practice Minor ailment service - Acne, Bites | Not applicable | Completed | Universidad de Granada | 20987 | 2020-10-01 | 2023-12-07 |
| A User Study of the Soniflow System for Nasal Congestion Relief Soniflow System - Nasal Congestion | Not applicable | Completed | Third Wave Therapeutics | 50 | 2020-07-15 | 2023-10-12 |
| BNO 1030 Extract (Imupret) in the Treatment of Mild Forms of COVID-19 BNO 1030, Standard care - Covid19, Nasopharyngitis | Phase 4 | Completed | Ivano-Frankivsk National Medical University | 133 | 2020-05-01 | 2021-03-15 |
| Chlorpheniramine Maleate Nasal Spray for Chronic Rhinitis CPM, Placebo - Allergic Rhinitis, Nasal Congestion | Phase 2 / Phase 3 | Withdrawn | Larkin Community Hospital | 2019-07-30 | 2023-10-16 | |
| The Safety and Efficacy of a SinuSonic Intervention SinuSonic Device - Nasal Congestion | Not applicable | Completed | Medical University of South Carolina | 40 | 2019-03-31 | 2021-04-22 |
| Investigation of Kinetic Oscillation Stimulation by the Chordate System S101 in the Treatment of Non Allergic Rhinitis Chordate S101, Chordate S101 Placebo - Nasal Congestion, Non-allergic Rhinitis | Not applicable | Completed | Chordate Medical | 279 | 2018-05-07 | 2023-09-22 |
| A Study to Compare Two Formulations of Xylometazoline/Dexpanthenol Nasal Spray for the Treatment of Nasal Congestion. xylo+dex nasal spray (0.1 mg+5 mg/dose), Nasic - Nasal Congestion | Phase 3 | Completed | McNeil AB | 140 | 2018-02-26 | 2018-10-18 |
| Efficacy and Safety of Pediatric Drugs in Nasal Congestion Naridrin, Afrin - Nasal Congestion | Phase 3 | Completed | EMS | 292 | 2018-01-16 | 2019-10-16 |
| Study on Hypertonic Saline Nasal Spray Phytosun, decongestant, nasal spray - Nasal Congestion | Not applicable | Completed | Omega Pharma | 50 | 2014-03-01 | 2015-02-20 |
| Market Potential of Carbon Dioxide Nasal Spray Carbon Dioxide - Nasal Congestion | Phase 2 | Completed | GlaxoSmithKline | 147 | 2013-11-01 | 2015-04-30 |
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Nasal Obstruction (32) · Common Cold (8) · Cough (5) · Rhinitis, Allergic (5) · Headache (4) · Influenza, Human (3) · Pharyngitis (3) · Respiratory Tract Infections (3) · Rhinorrhea (3) · Sneezing (3) · Fever (2) · Myalgia (2) · Acne Vulgaris (1) · Anosmia (1) · Bites and Stings (1)
Airway Obstruction (32) · Nose Diseases (32) · Otorhinolaryngologic Diseases (32) · Respiration Disorders (32) · Respiratory Insufficiency (32) · Respiratory Tract Diseases (32) · Infections (13) · RNA Virus Infections (11) · Virus Diseases (11) · Respiratory Tract Infections (10) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (9) · Picornaviridae Infections (8) · Signs and Symptoms, Respiratory (8) · Hypersensitivity, Immediate (6)
Standard of Care (3) · Acetaminophen (2) · Chlorpheniramine (2) · Diphenhydramine (2) · Nasal Lavage (2) · Oxymetazoline (2) · Pseudoephedrine (2) · Caffeine (1) · Carbon Dioxide (1) · Dimethindene (1) · N-myristoyl-alaninol (1) · Naphazoline (1) · Nasal Sprays (1) · Phenylephrine (1) · Pyrilamine (1)
BioCryst Pharmaceuticals (2) · Church & Dwight Company, Inc. (2) · GlaxoSmithKline (2) · Johnson & Johnson Consumer and Personal Products Worldwide (2) · McNeil AB (2) · Third Wave Therapeutics (2) · Aardvark Medical Company (1) · Ache Laboratorios Farmaceuticos S.A. (1) · Bayer (1) · Brainfarma Industria Química e Farmacêutica S/A (1) · C.O.C. Farmaceutici S.r.l. (1) · California Pacific Medical Center Research Institute (1) · Chiayi Christian Hospital (1) · Chordate Medical (1) · Clayton Sleep Insititute (1)
United States (11) · Brazil (4) · United Kingdom (4) · Italy (3) · Belgium (2) · Canada (2) · Czechia (2) · Poland (2) · Russia (2) · Spain (2) · Ukraine (2) · Argentina (1) · Australia (1) · Bosnia and Herzegovina (1) · Bulgaria (1)
Jacob Johnson, MD (2) · Melissa Israel, BS (2) · Alison Hughes (1) · Anna Rynkiewicz, MD (1) · Aynur Aytekin Ozdemir, Professor (1) · Dmitry Lioznov, MD (1) · Elisabeth A Kruse, PhD (1) · Eric Powell, PhD (1) · Konstantin A Zakharov, MD (1) · Marcos A Sanchez-Gonzalez (1) · Moutaz SM Jawad, MB ChB FRCP (1) · Richard Schwartz, MD (1)
PMID 23985625, PMID 25115871, PMID 27178892, PMID 27513397, PMID 32104962, PMID 32312677, PMID 40677297, PMID 42747526