5 completed, 2 withdrawn, 1 recruiting, 1 terminated. 9 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 5, Withdrawn 2, Recruiting 1, Terminated 1 |
| Phase 2 | 1 | Withdrawn 1 |
Follow Nasal Congestion: new trials by email Literature Review of Nasal Congestion trials Research Report on Nasal Congestion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in Adults dipyrone monohydrate 1000 mg + chlorpheniramine maleate 4 mg + caffeine 60 mg, dipyrone monohydrate 500 mg + chlorpheniramine maleate 2 mg + caffeine 30 mg, Placebo - Common Cold/Flu, Nasal Congestion | Phase 3 | Recruiting | Brainfarma Industria Química e Farmacêutica S/A | 620 | 2026-05-08 | 2026-06-16 |
| Chlorpheniramine Maleate Nasal Spray for Chronic Rhinitis CPM, Placebo - Allergic Rhinitis, Nasal Congestion | Phase 2 / Phase 3 | Withdrawn | Larkin Community Hospital | 2019-07-30 | 2023-10-16 | |
| A Study to Compare Two Formulations of Xylometazoline/Dexpanthenol Nasal Spray for the Treatment of Nasal Congestion. xylo+dex nasal spray (0.1 mg+5 mg/dose), Nasic - Nasal Congestion | Phase 3 | Completed | McNeil AB | 140 | 2018-02-26 | 2018-10-18 |
| Efficacy and Safety of Pediatric Drugs in Nasal Congestion Naridrin, Afrin - Nasal Congestion | Phase 3 | Completed | EMS | 292 | 2018-01-16 | 2019-10-16 |
| Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu Paracetamol (500 mg)/dimethindene maleate (1 mg)/ phenylephrine hydrochloride (10 mg) tablets, Paracetamol (500 mg) tablets - Upper Respiratory Tract Infection, Nasal Congestion | Phase 3 | Completed | Novartis | 341 | 2013-07-01 | 2017-03-03 |
| Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis Group 1, Group 2 - Nasal Congestion, Cough | Phase 3 | Withdrawn | Ache Laboratorios Farmaceuticos S.A. | 2011-08-01 | 2017-07-13 | |
| A Study to Evaluate the Efficacy and Safety of IV Peramivir in Addition to Standard of Care Compared to Standard of Care Alone in Adults and Adolescents Who Are Hospitalized Due to Influenza Peramivir+SOC, Placebo+SOC - Cough, Sore Throat | Phase 3 | Terminated | BioCryst Pharmaceuticals | 405 | 2009-11-01 | 2015-02-12 |
| Safety Study of IV Peramivir in Hospitalized Subjects With Confirmed or Suspected Influenza Peramivir - Seasonal Influenza, Cough | Phase 3 | Completed | BioCryst Pharmaceuticals | 234 | 2009-10-01 | 2015-02-12 |
| Effect of Heated Humidity With Thermosmart™ Compared to an Intranasal Steroid in Improving Compliance and Nasal Symptoms in Patients Using Continuous Positive Airway Pressure Thermosmart & placebo, Placebo Device & Nasacort, Placebo Arm - Obstructive Sleep Apnea, Nasal Congestion | Phase 3 | Completed | Clayton Sleep Insititute | 44 | 2007-09-01 | 2010-07-07 |
Nasal Obstruction (9) · Common Cold (3) · Cough (3) · Influenza, Human (3) · Headache (2) · Pharyngitis (2) · Fatigue (1) · Fever (1) · Myalgia (1) · Respiratory Tract Infections (1) · Rhinitis, Allergic (1) · Rhinorrhea (1) · Sleep Apnea, Obstructive (1) · Sneezing (1)
Airway Obstruction (9) · Nose Diseases (9) · Otorhinolaryngologic Diseases (9) · Respiration Disorders (9) · Respiratory Insufficiency (9) · Respiratory Tract Diseases (9) · Infections (5) · RNA Virus Infections (5) · Virus Diseases (5) · Pathological Conditions, Signs and Symptoms (4) · Respiratory Tract Infections (4) · Signs and Symptoms (4) · Signs and Symptoms, Respiratory (4) · Orthomyxoviridae Infections (3) · Picornaviridae Infections (3)
Chlorpheniramine (2) · Acetaminophen (1) · Caffeine (1) · Dimethindene (1) · Naphazoline (1) · Oxymetazoline (1) · Phenylephrine (1) · Pyrilamine (1) · Triamcinolone (1) · dexpanthenol (1) · peramivir (1)
BioCryst Pharmaceuticals (2) · Ache Laboratorios Farmaceuticos S.A. (1) · Brainfarma Industria Química e Farmacêutica S/A (1) · Clayton Sleep Insititute (1) · EMS (1) · Larkin Community Hospital (1) · McNeil AB (1) · Novartis (1)
Brazil (4) · United States (4) · Canada (2) · Russia (2) · Argentina (1) · Australia (1) · Belgium (1) · Bosnia and Herzegovina (1) · Bulgaria (1) · Chile (1) · Czechia (1) · Germany (1) · Hungary (1) · India (1) · Israel (1)
Alison Hughes (1) · Dmitry Lioznov, MD (1) · Eric Powell, PhD (1) · Konstantin A Zakharov, MD (1) · Marcos A Sanchez-Gonzalez (1) · Tatiana E Morozova, MD (1) · Vladimir Popov, MD (1) · Zhanna M Sizova, MD (1)