37 completed, 8 unknown, 7 recruiting, 6 active not recruiting. 30 Not applicable, 10 Phase 1, 7 Phase 4, 4 Phase 2, 1 Phase 3.
Follow Opiate Overdose: new trials by email Literature Review of Opiate Overdose trials Research Report on Opiate Overdose
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Naloxone for Opioid Associated Out of Hospital Cardiac Arrest Naloxone 2 MG, Saline 2ml - Heart Arrest, Out-Of-Hospital, Opioid Overdose | Phase 2 | Not yet recruiting | University of California, San Francisco | 98 | 2027-03-01 | 2026-09-11 |
| Evaluation of Clinical Decision Support in Opioid Tapering Observational study without a prospective intervention - Medication Abuse, Harm Reduction | Not yet recruiting | University of Colorado, Denver | 200000 | 2026-11-01 | 2026-09-30 | |
| A Bundled Intervention to End Opioid Overdoses Bundled intervention (Experimental), control group, Buprenorphine (Experimental) - Opioid Use Disorder, Opioid Overdose | Phase 4 | Recruiting | University of Alabama at Birmingham | 160 | 2026-09-07 | 2026-10-02 |
| Pharmacokinetic (PK) Evaluation of Nalmefene Formulations Nalmefene + 0.94% MgCl2, Nalmefene Hydrochloride Injection - Opioid Overdose | Phase 1 | Completed | Knoa Pharma LLC | 13 | 2026-02-06 | 2026-06-05 |
| Serious Game to Teach Opioid Overdose Response Serious game training - Opioid Overdose | Phase 2 | Not yet recruiting | University of Nevada, Reno | 850 | 2026-02-01 | 2024-12-11 |
| UnityPhilly Response App for Overdose Reversal UnityPhilly app - Opioid Overdose | Not applicable | Recruiting | Drexel University | 450 | 2025-09-16 | 2026-07-20 |
| A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose Naloxone-responder: A volunteer first responder system connected to emergency dispatch service and alerting overdose and first aid educated volunteers with naloxone to suspected opioid overdoses - Opioid Overdose | Not applicable | Recruiting | Region Skane | 1000 | 2025-09-01 | 2025-12-17 |
| Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary Care Machine Learning-Based Clinical Decision Support: Overdose Prevention Alert (OPA) Intervention - Opiate Overdose, Opioid-Related Disorders | Not applicable | Active not recruiting | University of Pittsburgh | 674 | 2025-04-08 | 2026-04-13 |
| THRIVE: Culturally AdapTed Harm Reduction Intervention harm reduction intervention - Opioid Use, Stimulant Use | Not applicable | Completed | Brittany Miller-Roenigk | 63 | 2025-04-02 | 2026-06-30 |
| Quantitative Xylazine Measurement in ED Opioid Overdose, Substance Use Disorders | Completed | Icahn School of Medicine at Mount Sinai | 75 | 2025-04-01 | 2026-03-25 | |
| Machine-Learning Prediction and Reducing Overdoses With EHR Nudges EHR-Embedded Elevated-Risk Flag, EHR-Embedded Elevated-Risk Flag with Behavioral Nudges, Usual Care - Opioid Overdose, Opioid Use | Not applicable | Active not recruiting | University of Pittsburgh | 1350 | 2025-03-10 | 2026-10-06 |
| A Bundled Intervention a bundled intervention, control group - Opioid Use Disorder, Opioid Overdose | Phase 1 / Phase 2 | Recruiting | University of Alabama at Birmingham | 190 | 2025-02-13 | 2026-02-23 |
| Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data Sub-acute stabilization - Opioid Use Disorder, Opioid Use | Not applicable | Recruiting | University of Washington | 40000 | 2024-12-15 | 2026-05-06 |
| Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose Nalmefene Injection, Naloxone Injection - Opioid Overdose, Opiate Overdose | Phase 3 | Withdrawn | University of New Mexico | 2024-08-26 | 2025-02-10 | |
| Blood Naloxone Levels Following Intradermal Injection in Humans intradermal naloxone, microneedle injection - Opioid Overdose | Phase 4 | Withdrawn | Johns Hopkins University | 2024-08-01 | 2024-11-01 | |
| Clinical Decision Support to Improve System Naloxone Co-prescribing Naloxone Co-prescribing Clinical Decision Support (CDS) - Medication Abuse, Harm Reduction | Completed | University of Colorado, Denver | 114272 | 2024-07-01 | 2026-09-29 | |
| Vending Machine Naloxone Distribution for Your Community (VENDY) VENDY - Harm Reduction, Naloxone | Phase 4 | Active not recruiting | University of Colorado, Denver | 4000 | 2024-06-01 | 2026-06-02 |
| Opioid Rapid Response System: Naloxone Training in Communities Opioid Rapid Resonse System (ORRS) training, Non-active opioid overdose response training - Opioid Overdose | Not applicable | Completed | University of Missouri-Columbia | 773 | 2024-05-24 | 2026-08-19 |
| Improving Availability of Intranasal Naloxone Enhanced Overdose Education (EOE), Standard education - Opioid Overdose | Not applicable | Unknown | Hartford Hospital | 84 | 2024-03-01 | 2024-06-07 |
| Safety, Tolerability, and Pharmacokinetics of CSX-1004 CSX-1004, Placebo - Opioid Overdose, Opioid Use Disorder | Phase 1 | Completed | Cessation Therapeutics, Inc. | 32 | 2023-08-01 | 2024-08-21 |
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Opioid-Related Disorders (22) · Substance-Related Disorders (11) · Drug Overdose (10) · Harm Reduction (10) · Respiratory Insufficiency (5) · Behavior, Addictive (2) · Chemically-Induced Disorders (2) · Death (2) · Emergencies (2) · Hypoventilation (2) · Mental Disorders (2) · Acute Pain (1) · Alcoholism (1) · Anxiety Disorders (1)
Drug Misuse (68) · Prescription Drug Misuse (68) · Narcotic-Related Disorders (67) · Chemically-Induced Disorders (66) · Mental Disorders (66) · Drug Overdose (58) · Substance-Related Disorders (57) · Opioid-Related Disorders (46) · Behavior (15) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (6) · Pathologic Processes (5) · Respiration Disorders (5) · Respiratory Tract Diseases (5) · Neurologic Manifestations (4)
Naloxone (9) · nalmefene (5) · Buprenorphine (2) · Buprenorphine, Naloxone Drug Combination (2) · Control Groups (2) · Surveys and Questionnaires (2) · Therapeutics (2) · Analgesics, Opioid (1) · Community-Institutional Relations (1) · Health Resources (1) · Injections (1) · Interviews as Topic (1) · Magnesium Chloride (1) · Methods (1) · Observation (1)
Brown University (3) · New York State Psychiatric Institute (3) · University of Alabama at Birmingham (3) · University of Colorado, Denver (3) · Drexel University (2) · Kaiser Permanente (2) · Nationwide Children's Hospital (2) · Purdue Pharma LP (2) · Region Skane (2) · University of California, San Francisco (2) · University of Pittsburgh (2) · University of Washington (2) · Yale University (2) · Auburn University (1) · BC Centre on Substance Use (1)
United States (54) · Canada (4) · Sweden (3) · United Kingdom (2) · Denmark (1) · Egypt (1) · Jordan (1)
Brandon DL Marshall, PhD (3) · Gary Smith, MD, DRPH (2) · Li Li, MD;PhD (2) · Nichole Michaels, PhD (2) · Stephen Lankenau, PhD (2) · Stephen McNulty, DO (2) · Aaron Orkin, MD (1) · Abdullah Hiyari, MD (1) · Anh P Nguyen, PhD (1) · Barrot Lambdin, PhD, MPH (1) · Brittany Miller-Roenigk, PhD (1) · Caitlin Bonney, MD (1) · Caleb Banta-Green, PhD, MPH, MSW (1) · Carol Strike, PhD (1)
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