101 completed, 22 unknown, 16 recruiting, 15 active not recruiting. 91 Not applicable, 16 Phase 4, 14 Phase 1, 7 Phase 2, 2 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Permanent Supportive Housing Overdose Prevention+ Study TA Intervention - Overdose, Substance Use | Not applicable | Not yet recruiting | NYU Langone Health | 2940 | 2027-07-01 | 2026-05-06 |
| Naloxone for Opioid Associated Out of Hospital Cardiac Arrest Naloxone 2 MG, Saline 2ml - Heart Arrest, Out-Of-Hospital, Opioid Overdose | Phase 2 | Not yet recruiting | University of California, San Francisco | 98 | 2027-03-01 | 2026-09-11 |
| The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study Community Paramedic Standard of Care (CP SOC), CROSSROADS - Opioid Use Disorder, Overdose, Drug | Not applicable | Not yet recruiting | Duke University | 400 | 2027-02-01 | 2026-10-14 |
| Clinician Practice Companion to Address Youth Substance Use Practice Companion - Substance Use, Substance-Related Disorders | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2027-01-01 | 2026-10-07 |
| Disease Intervention Specialist (DIS) for SUD Substance Use Disorder (SUD), Opioid Use Disorder | Not yet recruiting | Ohio State University | 1200 | 2026-12-01 | 2026-10-15 | |
| A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk Aim 3 Brief youth overdose prevention education, Usual Standard of Care - Overdose | Not applicable | Not yet recruiting | Boston Medical Center | 648 | 2026-11-01 | 2026-10-01 |
| Evaluation of Clinical Decision Support in Opioid Tapering Observational study without a prospective intervention - Medication Abuse, Harm Reduction | Not yet recruiting | University of Colorado, Denver | 200000 | 2026-11-01 | 2026-09-30 | |
| HIV/STI/HCV Testing and Overdose Prevention Among Survivors of Sex Trafficking Sex Trafficking Survivor-Developed Digital Crowdsourced Intervention - HIV Testing, STI | Not applicable | Not yet recruiting | Columbia University | 368 | 2026-10-01 | 2026-01-28 |
| A Bundled Intervention to End Opioid Overdoses Bundled intervention (Experimental), control group, Buprenorphine (Experimental) - Opioid Use Disorder, Opioid Overdose | Phase 4 | Recruiting | University of Alabama at Birmingham | 160 | 2026-09-07 | 2026-10-02 |
| Overdose Prevention Centers and Behavioral Health Overdose | Not yet recruiting | NYU Langone Health | 500 | 2026-09-01 | 2026-03-02 | |
| Behavioral Safety and Fentanyl Education: BSAFE BSAFE Intervention, Attention control - Drug Overdose, Drug Overdose Accidental | Not applicable | Recruiting | San Francisco Department of Public Health | 160 | 2026-08-11 | 2026-08-18 |
| The ENHANCE Project Toolkit Connections mHealth Application - Substance Related Disorder, Drug Overdose | Not applicable | Recruiting | University of Wisconsin, Madison | 40 | 2026-07-01 | 2026-10-16 |
| Justice Community Overdose Innovation Network II TCU Hub Core-interagency community engagement approach, Enhanced-Core plus community engagement specialist - Substance Use Disorder (SUD), Drug Overdose | Not applicable | Not yet recruiting | Texas Christian University | 1620 | 2026-07-01 | 2026-04-14 |
| Kentucky Women's Justice Community Overdose Innovation Network - Phase II Overdose Prevention Intervention Package (OPIP) - Overdose Risk, Opioid Use Disorder | Not applicable | Recruiting | Michele Staton | 300 | 2026-06-23 | 2026-09-16 |
| Pharmacokinetic (PK) Evaluation of Nalmefene Formulations Nalmefene + 0.94% MgCl2, Nalmefene Hydrochloride Injection - Opioid Overdose | Phase 1 | Completed | Knoa Pharma LLC | 13 | 2026-02-06 | 2026-06-05 |
| Serious Game to Teach Opioid Overdose Response Serious game training - Opioid Overdose | Phase 2 | Not yet recruiting | University of Nevada, Reno | 850 | 2026-02-01 | 2024-12-11 |
| A Hybrid Program to Prevent Substance Use Risk Among Upper Elementary School Students Using a Positive Youth Development Approach School-based Hybrid Intervention to Prevent Vaping and Prescription Drug Misuse - Vaping, E Cig Use | Not applicable | Not yet recruiting | Christopher Williams | 3000 | 2026-01-01 | 2025-09-09 |
| Trauma-informed Intervention to Reduce Substance Use and to Support Community Transition TAU + TRUST, TAU + TRUST + Re-entry Recovery Support, Treatment as Usual (TAU) - Substance Use Disorder (SUD) | Not applicable | Enrolling by invitation | Michele Staton | 264 | 2025-12-09 | 2026-06-09 |
| Older Adults' Attitudes Towards Stopping Aspirin Additional harm information, Less information - Medication Overuse | Not applicable | Completed | University of Michigan | 2819 | 2025-11-10 | 2026-04-29 |
| UnityPhilly Response App for Overdose Reversal UnityPhilly app - Opioid Overdose | Not applicable | Recruiting | Drexel University | 450 | 2025-09-16 | 2026-07-20 |
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Drug Overdose (102) · Opiate Overdose (68) · Opioid-Related Disorders (50) · Substance-Related Disorders (39) · Harm Reduction (14) · Prescription Drug Overuse (9) · HIV Infections (5) · Respiratory Insufficiency (5) · Alcoholism (4) · Behavior, Addictive (4) · Risk-Taking (4) · Chemically-Induced Disorders (3) · Emergencies (3) · Marijuana Abuse (3)
Drug Misuse (177) · Chemically-Induced Disorders (174) · Mental Disorders (174) · Substance-Related Disorders (138) · Narcotic-Related Disorders (95) · Drug Overdose (58) · Opioid-Related Disorders (46) · Behavior (34) · Pathological Conditions, Signs and Symptoms (20) · Pathologic Processes (13) · Respiratory Tract Diseases (10) · Infections (9) · Signs and Symptoms (9) · Disease Attributes (8)
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Norwegian University of Science and Technology (7) · Kaiser Permanente (6) · NYU Langone Health (5) · University of Michigan (5) · Brown University (4) · Johns Hopkins Bloomberg School of Public Health (4) · University of Alabama at Birmingham (4) · University of Pennsylvania (4) · New York State Psychiatric Institute (3) · RTI International (3) · Region Skane (3) · San Francisco Department of Public Health (3) · University of Cincinnati (3) · University of Colorado, Denver (3) · VA Office of Research and Development (3)
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Toril A Nagelhus Hernes, phd prof (4) · Brandon DL Marshall, PhD (3) · Ingrid Binswanger, MD (3) · Jason Glanz, PhD (3) · Theresa Winhusen, PhD (3) · Amy Yule, MD (2) · Carl Latkin, PhD (2) · David J Lowe, MBChB BMSc FRCEM (2) · Gary Smith, MD, DRPH (2) · Joseph A Simonetti, MD MPH (2) · Kelly Doran, MD (2) · Li Li, MD;PhD (2) · Nichole Michaels, PhD (2) · Stephen Lankenau, PhD (2) · Stephen McNulty, DO (2)
PMID 10221784, PMID 14728706, PMID 21207237, PMID 21323558, PMID 21711255, PMID 22847602, PMID 22974490, PMID 22988840, PMID 23556549, PMID 23932166, PMID 24290406, PMID 26810758, PMID 27004905, PMID 27062245, PMID 28113004, PMID 28144724, PMID 28893306, PMID 29049282, PMID 29436397, PMID 29568976, PMID 30143830, PMID 30621699, PMID 30837247, PMID 31234786, PMID 31492795, PMID 31556537, PMID 31722937, PMID 32028921, PMID 32651887, PMID 32718926, PMID 32954238, PMID 33059200, PMID 33070058, PMID 33086156, PMID 33091842, PMID 33091843, PMID 33091844, PMID 33103603, PMID 33184084, PMID 33243291, PMID 33651243, PMID 33941089, PMID 33978598, PMID 34009877, PMID 34223388, PMID 34236298, PMID 34301246, PMID 34729851, PMID 34758881, PMID 34913326
R01DA042059 (3), 2014 (2), R61DA057610 (2), R61DA062217 (2), 1IK2HX002861-01A2 (1), 1RM1DA064502 (1), 1UF1MH121949-01 (1), 1UM1DA049394 (1), 1UM1DA049406 (1), 1UM1DA049412 (1), 1UM1DA049415 (1), 1UM1DA049417 (1), 2009 (1), 2015 (1), 2016 (1)