1694 completed, 258 unknown, 203 terminated, 113 recruiting. 2483 Phase 3, 357 Phase 2.
Follow Musculoskeletal Diseases: new trials by email Literature Review of Musculoskeletal Diseases trials Research Report on Musculoskeletal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries | Phase 2 / Phase 3 | Not yet recruiting | VA Office of Research and Development | 300 | 2027-10-01 | 2026-08-04 |
| Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT Trametinib - HCM, Noonan Syndrome and Other Rasopathy | Phase 3 | Not yet recruiting | Carelon Research | 25 | 2027-08-01 | 2026-09-14 |
| Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | Genascence Corporation | 240 | 2027-07-01 | 2026-09-21 |
| Phase 3 Bunionectomy Study CPL-01, saline placebo - Postoperative Pain, Bunion | Phase 3 | Not yet recruiting | Cali Pharmaceuticals LLC | 112 | 2027-03-01 | 2026-10-21 |
| A Study to Investigate the Safety, Pharmacokinetics (PK), and Efficacy of Garetosmab in Children and Adolescents With Fibrodysplasia Ossificans Progressiva (FOP) garetosmab - Fibrodysplasia Ossificans Progressiva, FOP | Phase 3 | Not yet recruiting | Regeneron Pharmaceuticals | 18 | 2027-02-02 | 2026-10-20 |
| Phase 3 Long Term Safety Extension Study of LUM-201 in Children With Growth Hormone Deficiency LUM-201 - Growth Hormone Deficiency (GHD) | Phase 3 | Not yet recruiting | Lumos Pharma | 150 | 2027-02-01 | 2026-07-08 |
| A Study of Zasocitinib in Adults With Psoriatic Arthritis (LATITUDE PsA NeXt) Placebo, Zasocitinib - Psoriatic Arthritis | Phase 3 | Not yet recruiting | Takeda | 644 | 2027-01-11 | 2026-10-27 |
| HTO and Tranexamic Acid Study Tranexamic Acid, Routine medial opening wedge high tibial osteotomy - Osteoarthritis, Knee | Phase 3 | Not yet recruiting | Western University, Canada | 200 | 2027-01-01 | 2026-09-17 |
| A Study to Investigate Arbaclofen ER Tablets for the Treatment of Spasticity in Patients With Multiple Sclerosis Arbaclofen, Placebo - Spasticity | Phase 3 | Not yet recruiting | RVL Pharmaceuticals, Inc. | 442 | 2027-01-01 | 2025-12-03 |
| Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers Deucravacitinib - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 3 | Not yet recruiting | Bristol-Myers Squibb | 2300 | 2026-12-31 | 2026-09-03 |
| A Study to Understand How Nerandomilast Works in People With Active Idiopathic Inflammatory Myopathies Placebo, Nerandomilast - Idiopathic Inflammatory Myopathies | Phase 3 | Not yet recruiting | Boehringer Ingelheim | 270 | 2026-12-14 | 2026-10-29 |
| ACT4RHD is an Open-label, Randomised, Adaptive Platform Trial to Evaluate Novel and Repurposed Clinical Interventions for Patients With Acute Rheumatic Fever and Carditis. ACT4RHD Seeks to Determine Whether These Interventions Reduce RHD Severity at 6 Months. Hydroxychloroquine (HCQ), No Hydroxychloroquine (HCQ), Prednisone or Prednisolone - Rheumatic Fever, Rheumatic Heart Disease in Children | Phase 3 | Not yet recruiting | Starship Child Health, Te Toka Tumai Auckland | 600 | 2026-12-01 | 2026-10-07 |
| Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction Tranexamic Acid, Placebo - Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture | Phase 3 | Not yet recruiting | Dave Bernholt | 100 | 2026-11-01 | 2026-10-26 |
| DEPART Study at Yale Radiation Therapy - Dupuytren's Contracture | Phase 3 | Not yet recruiting | Yale University | 158 | 2026-11-01 | 2026-10-13 |
| Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT intermittent theta burst stimulation, LoveYourBrain Yoga Program - Chronic Low Back Pain, Musculoskeletal Pain | Phase 3 | Not yet recruiting | VA Office of Research and Development | 213 | 2026-10-30 | 2026-10-26 |
| the Effect of Ginkgo Biloba on Rheumatoid Arthritis Patients Ginkgo Biloba Extract (120 mg ) manufuctured by EMA PHARM - Rheumatoid Arthritis (RA), Manegmentof Rheumatoid Arthritis | Phase 2 / Phase 3 | Not yet recruiting | Ain Shams University | 50 | 2026-10-15 | 2026-10-06 |
| A Study to Evaluate Efficacy and Safety of a Single Intra-Articular Injection of HL-01 in the Treatment of Pain in Symptomatic Knee Osteoarthritis Sodium hyaluronate solution - 3.36%, Sterile buffered solution - Osteo Arthritis of the Knee | Phase 3 | Not yet recruiting | IBSA Institut Biochimique SA | 704 | 2026-09-30 | 2026-10-07 |
| Intra Articular Injection of Peripheral Blood Mononuclear Cells for Knee Osteoarthritis High-dose PCP-PBMCs injection, Solu-Medrol, Low-dose PCP-PBMCs injection - Knee Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | DuoGenic StemCells Corporation (DGSC) | 240 | 2026-09-30 | 2026-07-20 |
| The Effect of Nicorandil on Rheumatoid Arthritis Patients Nicorandil Oral Tablet, Placebo, conventional synthetic antirheumatic drugs (cDMARDs) - Rheumatoid Arthritis (RA) | Phase 2 / Phase 3 | Recruiting | Ain Shams University | 70 | 2026-09-06 | 2026-09-16 |
| Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery. PAI, PAI + steroid, PAI + zilretta - Knee Osteoarthritis, Musculoskeletal Disease | Phase 2 / Phase 3 | Recruiting | Walter Reed National Military Medical Center | 240 | 2026-09-01 | 2026-08-19 |
Showing 20 of 2483. Sign in to see all of them.
Arthritis, Rheumatoid (451) · Osteoarthritis (319) · Osteoarthritis, Knee (257) · Osteoporosis (194) · Pain (128) · Arthritis (113) · Arthritis, Psoriatic (105) · Fibromyalgia (97) · Spondylitis, Ankylosing (82) · Arthritis, Juvenile (79) · Bone Diseases, Metabolic (75) · Osteoporosis, Postmenopausal (74) · Muscle Spasticity (64) · Muscular Dystrophy, Duchenne (59)
Joint Diseases (1371) · Arthritis (1191) · Rheumatic Diseases (1174) · Skin and Connective Tissue Diseases (810) · Bone Diseases (770) · Connective Tissue Diseases (675) · Immune System Diseases (599) · Autoimmune Diseases (574) · Pathological Conditions, Signs and Symptoms (537) · Nervous System Diseases (500) · Muscular Diseases (458) · Signs and Symptoms (412) · Nutritional and Metabolic Diseases (380) · Neurologic Manifestations (375)
Methotrexate (123) · tocilizumab (92) · Adalimumab (79) · Sodium Chloride (57) · Etanercept (51) · Denosumab (44) · Zoledronic Acid (44) · Human Growth Hormone (43) · Alendronate (40) · Botulinum Toxins, Type A (40) · Abatacept (38) · secukinumab (38) · Infliximab (37) · Certolizumab Pegol (36) · Rituximab (36)
Hoffmann-La Roche (87) · Novartis Pharmaceuticals (87) · Pfizer (75) · Amgen (63) · Eli Lilly and Company (63) · Bristol-Myers Squibb (31) · Abbott (28) · Janssen Research & Development, LLC (28) · Assistance Publique - Hôpitaux de Paris (27) · Novartis (24) · Organon and Co (24) · GlaxoSmithKline (20) · Merck Sharp & Dohme LLC (20) · Sanofi (18) · AbbVie (17)
United States (1051) · Germany (454) · Canada (445) · Spain (403) · Poland (386) · United Kingdom (384) · France (378) · Italy (333) · Australia (293) · Czechia (256) · Belgium (254) · Hungary (252) · Russia (248) · Japan (227) · South Korea (222)
PMID 27338778, PMID 36526796, PMID 36931693, PMID 29244149, PMID 30649524, PMID 32816215, PMID 34870800, PMID 38979716, PMID 30936738, PMID 33263165, PMID 36600185, PMID 36601090, PMID 37460782, PMID 37982966, PMID 40875187, PMID 28143815, PMID 33127856, PMID 36754548, PMID 36814062, PMID 37453736, PMID 37945286, PMID 25047021, PMID 31203228, PMID 34921355, PMID 38446397, PMID 30177460, PMID 34041702, PMID 34706874, PMID 35577477, PMID 36715850, PMID 37308218, PMID 37316690, PMID 38958913, PMID 39192350, PMID 40194794, PMID 41807031, PMID 41965705, PMID 42386286, PMID 21037195, PMID 22491018, PMID 26275429, PMID 26554876, PMID 27803138, PMID 29463520, PMID 29949132, PMID 30219772, PMID 31610021, PMID 33059710, PMID 33115760, PMID 34618347
2015 (38), 2023 (35), 2009 (33), 2016 (29), 2014 (26), 2019 (21), 2017 (19), 2018 (19), 2008 (18), 2005 (10), 2025 (9), 2004 (8), 1UG3AR076387-01 (1), 1UG3AR077360-01 (1), 1UL1RR025758 (1)