79 completed, 51 unknown, 37 recruiting, 17 not yet recruiting. 214 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 214 | Completed 79, Unknown 51, Recruiting 37, Not yet recruiting 17, Withdrawn 12, Active not recruiting 9, Terminated 6, Suspended 2, Enrolling by invitation 1 |
Follow Musculoskeletal Diseases: new trials by email Literature Review of Musculoskeletal Diseases trials Research Report on Musculoskeletal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-label Study of GC012F in Rheumatoid Arthritis. LD and GC012F CAR-T Cell Injection, GC012F CAR-T Cell Injection - Rheumatoid Arthritis | Early Phase 1 | Withdrawn | Institute of Hematology & Blood Diseases Hospital, China | 2027-12-01 | 2026-06-10 | |
| Metformin and ACLR Muscle Recovery Metformin, Placebo - Atrophy, Inflammation | Early Phase 1 | Not yet recruiting | University of Utah | 40 | 2026-11-01 | 2026-07-13 |
| Total Osteo-Cartilage Replacement for the Treatment of Osteoarthritis of Knee Total osteo-cartilage replacement of the distal femur and proximal tibia, including medial and lateral meniscus., allogenic bone and cartilage graft - Osteoarthritis (OA) of the Knee | Early Phase 1 | Not yet recruiting | AlSalam Hospital | 10 | 2026-11-01 | 2026-08-19 |
| Medication vs. Meditation for Chronic Knee Osteoarthritis Oral diclofenac potassium 50 mg, Mindfulness meditation - Knee Osteoarthristis | Early Phase 1 | Not yet recruiting | Florida State University | 30 | 2026-10-01 | 2026-09-23 |
| Evaluation of an Online Peri-operative Health Education Platform for Patients Undergoing Spine Surgery: Ready Set Recover Ready Set Recover - Medium-/Long-segment Spinal Fusion Patients, Spine Surgeons | Early Phase 1 | Not yet recruiting | National University of Natural Medicine | 60 | 2026-09-30 | 2026-08-17 |
| Orthobiological Therapies in Musculoskeletal Disorders PRP injection, Bone Marrow Concentrate (BMAC), Hyaluronic Acid (Viscosupplementation) - Musculoskeletal Diseases or Conditions | Early Phase 1 | Recruiting | PROREGEN | 300 | 2026-09-16 | 2026-09-17 |
| MDMA-assisted Therapy for Fibromyalgia MDMA - Fibromyalgia | Early Phase 1 | Recruiting | Spaulding Rehabilitation Hospital | 20 | 2026-09-15 | 2026-08-26 |
| CD19/BCMA-Targeted Universal CAR-T Cell Injection for the Treatment of Autoimmune Diseases RD06-05 CAR-T Cell Injection - SLE - Systemic Lupus Erythematosus, Systemic Sclerosis | Early Phase 1 | Not yet recruiting | Nanjing Bioheng Biotech Co., Ltd. | 30 | 2026-09-01 | 2026-07-16 |
| Collagenase Injection for Contracture Management Active XIAFLEX Collagenase injection - Contracture | Early Phase 1 | Not yet recruiting | The University of Texas Health Science Center, Houston | 15 | 2026-09-01 | 2026-07-09 |
| Collagenase Injection for Spasticity Management XIAFLEX Collagenase injection - Spasticity | Early Phase 1 | Not yet recruiting | The University of Texas Health Science Center, Houston | 15 | 2026-09-01 | 2026-07-09 |
| Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity Metformin, Placebo - Osteoarthritis (OA) of the Knee | Early Phase 1 | Recruiting | The University of Hong Kong | 100 | 2026-08-30 | 2026-08-18 |
| A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression repetetive transcranial magnetic stimulation - Knee Osteoarthritis, Depression | Early Phase 1 | Recruiting | University of California, Los Angeles | 30 | 2026-06-04 | 2026-07-06 |
| Long-Term Effects of Mobithron Advance on Knee Osteoarthritis Aims to Investigate the Effects of Mobithron Advance on OA Progression Type 2 collagen - Osteoarthritis (OA) of the Knee | Early Phase 1 | Recruiting | Universiti Sains Malaysia | 84 | 2026-05-03 | 2026-06-12 |
| A Study of BEN301 Injection in theTreatment of Autoimmune Diseases Single administration of 1x10^8 viable CD4+ CAR+ Foxp3+ cells., Single administration of 3x10^8 viable CD4+ CAR+ Foxp3+ cells. - Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA) | Early Phase 1 | Suspended | RenJi Hospital | 24 | 2026-04-20 | 2026-06-04 |
| MTS109 in Patients With Refractory Autoimmune Diseases MTS109 - Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies | Early Phase 1 | Recruiting | Shanghai Changzheng Hospital | 15 | 2026-03-24 | 2026-06-30 |
| Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases KN5601 - Rheumatic Diseases, Pediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese) | Early Phase 1 | Recruiting | The Children's Hospital of Zhejiang University School of Medicine | 36 | 2026-03-19 | 2026-03-24 |
| UCAR T-cell Therapy Targeting CD19/ BCMA(QT-019C) in Patients With Relapse/ Refractory Autoimmune Diseases UCAR-T cells - Systemic Lupus Erythematosus, Inflammatory Myopathy | Early Phase 1 | Withdrawn | The Affiliated Hospital of Xuzhou Medical University | 2026-03-01 | 2026-05-28 | |
| Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases anti-CD19/BCMA U CAR T cells - Autoimmune Diseases, Systemic Lupus Erythematosus | Early Phase 1 | Recruiting | Changhai Hospital | 60 | 2026-02-20 | 2026-02-25 |
| Stromal Vascular Fraction (SVF) for Knee Post-Trauma Osteoarthritis (PTOA) Adipose Derived (AD) Stromal Vascular Fraction (SVF) - Osteoarthritis | Early Phase 1 | Withdrawn | Wake Forest University Health Sciences | 2026-02-01 | 2026-02-27 | |
| Clinical Study of (A-319) in the Treatment of Active Rheumatoid Arthritis A-319 - Rheumatoid Arthritis (RA) | Early Phase 1 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 12 | 2026-01-08 | 2026-01-16 |
Showing 20 of 214. Sign in to see all of them.
Osteoarthritis, Knee (25) · Osteoarthritis (21) · Lupus Erythematosus, Systemic (20) · Myositis (20) · Arthritis, Rheumatoid (18) · Scleroderma, Systemic (14) · Sjogren's Syndrome (13) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (11) · Autoimmune Diseases (11) · Fibromyalgia (10) · Muscular Dystrophy, Duchenne (9) · Muscle Spasticity (8) · Bone Neoplasms (7) · Osteoporosis (7) · Bone Diseases, Metabolic (6)
Joint Diseases (103) · Rheumatic Diseases (85) · Arthritis (80) · Muscular Diseases (78) · Nervous System Diseases (70) · Pathological Conditions, Signs and Symptoms (54) · Neuromuscular Diseases (53) · Bone Diseases (52) · Skin and Connective Tissue Diseases (48) · Connective Tissue Diseases (44) · Immune System Diseases (43) · Signs and Symptoms (41) · Neurologic Manifestations (34) · Autoimmune Diseases (31)
Sodium Chloride (7) · Hyaluronic Acid (5) · 68Ga-FAPI (4) · Injections (4) · Lidocaine (4) · Acupuncture Therapy (3) · Adrenal Cortex Hormones (3) · Exercise (3) · Acetaminophen (2) · Botulinum Toxins, Type A (2) · Calcitriol (2) · Cyclophosphamide (2) · Gentamicins (2) · Growth Hormone (2) · Human Growth Hormone (2)
Peking Union Medical College Hospital (6) · Mayo Clinic (5) · Nanjing Bioheng Biotech Co., Ltd. (3) · PersonGen BioTherapeutics (Suzhou) Co., Ltd. (3) · Shanghai Yunying Medical Technology (3) · The University of Texas Health Science Center, Houston (3) · University of California, Los Angeles (3) · Bispebjerg Hospital (2) · Cairo University (2) · Cedars-Sinai Medical Center (2) · First Affiliated Hospital of Fujian Medical University (2) · Guangdong ProCapZoom Biosciences Co., Ltd. (2) · Loma Linda University (2) · Oregon Health and Science University (2) · Practitioners Alliance Network (2)
United States (80) · China (53) · Egypt (7) · Denmark (5) · Brazil (4) · Turkey (Türkiye) (4) · Hong Kong (3) · Spain (3) · United Kingdom (3) · Australia (2) · Belgium (2) · Canada (2) · France (2) · Portugal (2) · Austria (1)
He Huang, PhD (2) · Sheng Li, MD, PhD (2) · Sundeep Khosla, MD (2) · Ahmed Amr, Professor (1) · Amir Oron, MD (1) · Amy Killeen, DDS, MS (1) · Ann K Rosenthal, MD (1) · Anne L. Friedlander (1) · Anthony J. Bleyer, MD, M.S (1) · Anwar B Almutairi, PT, PhD (1) · Ashim Gupta, PhD, MBA (1) · Ashley Schneider, MD (1) · Atul Deodhar, M.D. (1) · Austin Stone, MD, PhD (1)
PMID 21544866, PMID 11033213, PMID 1139838, PMID 11408550, PMID 11782825, PMID 12795787, PMID 14158464, PMID 15008021, PMID 15276398, PMID 15840453, PMID 15930924, PMID 16360266, PMID 17372833, PMID 17383095, PMID 18778779, PMID 19576962, PMID 19588358, PMID 19819109, PMID 20360543, PMID 20391423, PMID 20594330, PMID 20687940, PMID 21102963, PMID 21267039, PMID 21526623, PMID 21827970, PMID 21946867, PMID 22027216, PMID 22163222, PMID 22200394, PMID 22298051, PMID 22530208, PMID 22753863, PMID 22828681, PMID 23028999, PMID 23139341, PMID 23629922, PMID 23672400, PMID 23969907, PMID 24034070, PMID 24119776, PMID 24440362, PMID 24482187, PMID 24497443, PMID 24532680, PMID 24600532, PMID 24886572, PMID 25013996, PMID 25816746, PMID 25905862
R01DK073039 (2), 1UL1TR001114-01 (1), 1UL1TR001863-01 (1), P30CA014089 (1), R01HD039343 (1)