6 completed, 1 not yet recruiting, 1 recruiting, 1 unknown. 9 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 6, Not yet recruiting 1, Recruiting 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Muscle Loss: new trials by email Literature Review of Muscle Loss trials Research Report on Muscle Loss
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide Calcium-HMB Plus Vitamin D3, Matching placebo - Type 2 Diabetes Mellitus (T2DM), Sarcopenia | Phase 2 | Not yet recruiting | Vanderbilt University Medical Center | 90 | 2026-12-01 | 2026-08-28 |
| A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2) (S)-pindolol benzoate, Semaglutide, Placebo to (S)-pindolol benzoate - Obesity, Muscle Loss | Phase 2 | Recruiting | Actimed Therapeutics Ltd | 120 | 2025-06-23 | 2026-02-17 |
| Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight Mgmt Enobosarm, Semaglutide - Muscle Loss, Obesity | Phase 2 | Completed | Veru Inc. | 168 | 2024-04-29 | 2025-09-17 |
| Nutritional Therapy in Late-onset Pompe Disease Multi-ingredient supplement (PDT-MIS), Placebo (PLA) - Pompe Disease, Muscle Loss | Phase 2 | Unknown | McMaster University | 28 | 2024-04-01 | 2023-11-14 |
| Pediatric Oncology Nutrition Intervention Trial Oral Nutrition Supplement, Tube Feed, Cyproheptadine - Pediatric Cancer, Nutrition Related Cancer | Phase 2 / Phase 3 | Completed | Corey Hawes | 20 | 2024-01-31 | 2026-10-08 |
| Study Testing Benefits of Ursolic Acid (UA) as a Countermeasure To Myopenia and Insulin Resistance in Chronic Spinal Cord Injury (SCI) Ursolic Acid, Strength Training - Spinal Cord Injuries, Tetraplegia | Phase 2 | Completed | University of Miami | 10 | 2023-03-27 | 2025-05-21 |
| Effect of High Protein Diet in Stroke Patients With Low Muscle Mass high protein diet, normal protein diet - Ischemic Stroke, Diet, Healthy | Phase 2 | Completed | Chang Gung Memorial Hospital | 110 | 2017-12-15 | 2023-03-30 |
| Musculoskeletal Effects of Bicarbonate potassium bicarbonate, Inactive placebo capsule - Muscle Loss, Fractures | Phase 2 | Completed | Tufts University | 244 | 2012-01-01 | 2015-10-19 |
| Essential Amino Acids Supplementation and Muscle Protein Synthesis Essential Amino Acids, Endurance exercise - Muscle Loss, Muscle Anabolism | Phase 1 / Phase 2 | Completed | United States Army Research Institute of Environmental Medicine | 23 | 2007-05-01 | 2017-07-21 |
Muscular Atrophy (9) · Obesity (4) · Child Nutrition Disorders (1) · Diabetes Mellitus, Type 2 (1) · Fractures, Bone (1) · Glycogen Storage Disease Type II (1) · Insulin Resistance (1) · Ischemic Stroke (1) · Lysosomal Storage Diseases (1) · Malnutrition (1) · Neoplasms (1) · Osteoporosis (1) · Paraplegia (1) · Quadriplegia (1) · Sarcopenia (1)
Atrophy (9) · Nervous System Diseases (9) · Neurologic Manifestations (9) · Neuromuscular Manifestations (9) · Pathological Conditions, Anatomical (9) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (9) · Nutritional and Metabolic Diseases (7) · Nutrition Disorders (5) · Body Weight (4) · Metabolic Diseases (4) · Overnutrition (4) · Overweight (4) · Central Nervous System Diseases (3) · Brain Diseases (2)
semaglutide (2) · Amino Acids, Essential (1) · Cholecalciferol (1) · Cyproheptadine (1) · Diet, High-Protein (1) · Enteral Nutrition (1) · Olanzapine (1) · Resistance Training (1) · Standard of Care (1) · Ursolic Acid (1) · beta-hydroxyisovaleric acid (1) · ostarine (1) · potassium bicarbonate (1)
Actimed Therapeutics Ltd (1) · Chang Gung Memorial Hospital (1) · Corey Hawes (1) · McMaster University (1) · Tufts University (1) · United States Army Research Institute of Environmental Medicine (1) · University of Miami (1) · Vanderbilt University Medical Center (1) · Veru Inc. (1)
United States (6) · Serbia (1) · Taiwan (1)
Bess Dawson-Hughes, M.D. (1) · Corey J Hawes, DCN, RD, CSO, CNSC, LD (1) · Mark S Nash, PhD (1) · Mark Tarnopololsky, MD/PhD (1) · Robb Flynn, PhD (1) · Stefan M Pasiakos, Ph.D. (1)
PMID 20739716, PMID 21389329, PMID 28842733, PMID 29211866
R01AR060261 (1), UL1TR001998 (1)