13 completed, 5 terminated, 4 unknown, 1 active not recruiting. 9 Phase 2, 5 Phase 3, 5 Phase 4, 3 Not applicable, 2 Early Phase 1.
Follow Cyproheptadine: new trials by email Literature Review of Cyproheptadine trials Research Report on Cyproheptadine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Use of Cyproheptadine in Pediatric Feeding Disorders Cyproheptadine, Nutritional Counseling, Behavioral Counseling - Pediatric Feeding Disorder, Chronic, Avoidant Restrictive Food Intake Disorder | Phase 4 | Completed | University of Miami | 18 | 2024-12-30 | 2026-06-04 |
| Effectiveness of Cyproheptadine Hydrochloride Against Appetite to Improve Children's Nutritional Status cyproheptadine hydrochloride, Giving placebo divided by 2 dose every 12 hours for 4 weeks. - Appetite Loss | Not applicable | Completed | Universitas Indonesia | 44 | 2024-11-04 | 2025-06-10 |
| A Study to Assess the Pharmacokinetic Profile of Prazosin and Cyproheptadine Prazosin + cyproheptadine, KT110 - Alcohol Use Disorder | Phase 1 | Completed | Kinnov Therapeutics | 12 | 2024-04-23 | 2025-03-13 |
| Pediatric Oncology Nutrition Intervention Trial Oral Nutrition Supplement, Tube Feed, Cyproheptadine - Pediatric Cancer, Nutrition Related Cancer | Phase 2 / Phase 3 | Completed | Corey Hawes | 20 | 2024-01-31 | 2026-10-08 |
| Serotonin Receptor Blockers in Ischemic Mitral Regurgitation Cyproheptadine 4 Mg Oral Tablet, Placebo - Ischemic Mitral Regurgitation | Phase 2 | Recruiting | Laval University | 214 | 2023-06-20 | 2023-11-15 |
| Effect of Fecal Microbiota Transplantation (FMT) in Pediatric Functional Gastrointestinal Disorders FMT, Conventional drugs - Functional Gastrointestinal Disorders | Phase 3 | Terminated | Biao Zou | 47 | 2023-04-03 | 2026-08-03 |
| Randomized-controlled Trial of the Effectiveness of COVID-19 Early Treatment in Community FluvoxaMINE Maleate 50 MG, Fluvoxamine, Bromhexine, Fluvoxamine, Cyproheptadine - Treatment Efficacy | Phase 4 | Completed | Chulalongkorn University | 1200 | 2021-10-01 | 2022-11-04 |
| Effect of Cyproheptadine on Ventilatory Support-free Days in Critically Ill Patients With COVID-19 Cyproheptadine - COVID-19 Pneumonia | Phase 3 | Unknown | Hospital de Clinicas de Porto Alegre | 274 | 2021-07-26 | 2021-08-03 |
| Pilot Study for Cyproheptadine in Hospitalized Patient for COVID-19 Cyproheptadine Hydrochloride 4 MG - Viral Pneumonia, COVID-19 Pneumonia | Phase 2 | Unknown | Ciusss de L'Est de l'Île de Montréal | 60 | 2021-06-01 | 2021-05-06 |
| Cyproheptadine in Severe COVID-19 : A Unblinded Randomized Trial Cyproheptadine Hydrochloride 4 MG - Viral Pneumonia, Serotonin Syndrome | Phase 3 | Unknown | Ciusss de L'Est de l'Île de Montréal | 200 | 2021-04-10 | 2021-04-02 |
| I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients Remdesivir, Imatinib Mesylate, Dexamethasone - COVID-19 | Phase 2 | Active not recruiting | QuantumLeap Healthcare Collaborative | 1500 | 2020-07-31 | 2026-03-16 |
| Clinical Outcome of a Patented Pharmaceutical Composition (KT-110) to Treat Alcohol Use Disorder While Avoiding Major Side Effects Cyproheptadine, Alpress LP - Alcohol Use Disorder | Phase 2 | Completed | Kinnov Therapeutics | 154 | 2019-11-30 | 2024-04-15 |
| Noninvasive Markers of Functional Nausea in Children Questionnaires, 4 channel electrogastrogram (EGG), 36 channel high resolution electrogastrogram (HR-EGG) - Nausea | Early Phase 1 | Completed | Vanderbilt University Medical Center | 42 | 2018-08-03 | 2026-04-22 |
| Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders Cyproheptadine - Feeding Behaviors | Phase 4 | Terminated | Medical College of Wisconsin | 4 | 2015-12-01 | 2020-01-31 |
| Altering Activation Patterns Post-stroke Cyproheptadine, Placebo for Cyproheptadine, Active Movement Practice (AMP) - Stroke, Muscle Spasticity | Not applicable | Completed | Shirley Ryan AbilityLab | 96 | 2015-11-01 | 2026-03-31 |
| A Study of Combination Therapy in Children With ADHD Methylphenidate ER, Cyproheptadine - ADHD, Attention Deficit Hyperactivity Disorder | Phase 4 | Completed | Douglas Sears | 99 | 2014-03-01 | 2015-04-10 |
| A Placebo-controlled Crossover Trial Using Cyproheptadine To Treat Children With Functional Abdominal Pain Cyproheptadine, sugar pill - Functional Abdominal Pain | Phase 2 | Terminated | University of Michigan | 4 | 2012-08-01 | 2017-08-30 |
| Molecular Markers of Neuroplasticity During Exercise in People With Incomplete Spinal Cord Injury escitalopram oxalate, Cyproheptadine, sugar pill - Spinal Cord Injury | Not applicable | Completed | T. George Hornby | 30 | 2011-12-01 | 2015-05-19 |
| Mechanisms of Neuromuscular Fatigue Post Stroke duloxetine, Cyproheptadine, Placebo - Stroke | Early Phase 1 | Completed | Medical College of Wisconsin | 27 | 2011-08-01 | 2015-11-05 |
| Cyproheptadine as an Appetite Stimulant Cyproheptadine, Sugar pill - Failure to Thrive | Phase 4 | Unknown | St. Justine's Hospital | 20 | 2010-12-01 | 2011-03-15 |
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Alcoholism (3) · COVID-19 (3) · Pneumonia, Viral (3) · Astrocytoma (2) · Body Weight Changes (2) · Burkitt Lymphoma (2) · Cachexia (2) · Choroid Plexus Neoplasms (2) · Dendritic Cell Sarcoma, Interdigitating (2) · Familial ependymoma (2) · Leukemia (2) · Lymphoma (2) · Lymphoma, Large-Cell, Anaplastic (2) · Malnutrition (2) · Medulloblastoma (2)
University of South Florida (3) · Ciusss de L'Est de l'Île de Montréal (2) · Kinnov Therapeutics (2) · Medical College of Wisconsin (2) · Biao Zou (1) · Brown University (1) · Chulalongkorn University (1) · Corey Hawes (1) · Douglas Sears (1) · Hospital de Clinicas de Porto Alegre (1) · Laval University (1) · QuantumLeap Healthcare Collaborative (1) · Shirley Ryan AbilityLab (1) · St. Justine's Hospital (1) · T. George Hornby (1)
United States (12) · Canada (3) · France (2) · Brazil (1) · China (1) · Indonesia (1) · Puerto Rico (1) · Thailand (1)
Alain Puech (1) · Alan Bradshaw, Ph.D. (1) · Cameron Hurst, PhD (1) · Corey J Hawes, DCN, RD, CSO, CNSC, LD (1) · Derek G Kamper, PhD (1) · Derek W Russell, MD (1) · Dhammika Leshan Wannigama, MD PhD (1) · Elliot Roth, MD (1) · Ismaeel Hashemi, MD (1) · Jeffrey P. Krischer, PhD (1) · Jennifer L. Mayer, MD (1) · Jose M Schuster, MD (1) · Kanokpoj Chanpiwat, MD (1) · Kathleen D Liu, MD (1) · Katika Akksilp, MD (1)
PMID 18989154, PMID 23262301, PMID 32113974, PMID 34473343, PMID 36054974, PMID 36883141, PMID 38516100, PMID 38597214, PMID 39592213, PMID 40462830, PMID 42799508
U10CA081920 (3), R01HD075813 (1), UL1TR001998 (1)